Results 21 to 30 of about 6,286 (187)
Chemokine Receptor CCR5 Antagonist Maraviroc: Medicinal Chemistry and Clinical Applications [PDF]
Current Topics in Medicinal Chemistry, 2014 The human immunodeficiency virus (HIV) causes acquired immumodeficiency syndrome (AIDS), one of the worst global pandemic. The virus infects human CD4 T cells and macrophages, and causes CD4 depletion. HIV enters target cells through the binding of the viral envelope glycoprotein to CD4 and the chemokine coreceptor, CXCR4 or CCR5.
Guoyan G, Xu, Jia, Guo, Yuntao, Wu
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Determination of HIV Tropism in Patients with Antiretroviral Therapy Failure in Arkhangelsk Region
Проблемы особо опасных инфекций, 2022 The aim of the study was to determine the tropism of the human immunodeficiency virus in patients with virological failure of antiretroviral therapy (ART) from the Arkhangelsk Region based on the analysis of the env gene V3 loop nucleotide sequence ...
Yu. V. Ostankova +5 more
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Total Synthesis of Anibamine, a Novel Natural Product as a Chemokine Receptor CCR5 Antagonist. [PDF]
ChemInform, 2007 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Guo, Li +3 more
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Staphylococcus aureus Infection and Persistence in Chronic Rhinosinusitis: Focus on Leukocidin ED
Toxins, 2020 Chronic rhinosinusitis (CRS) is thought to be a multifactorial disease that includes a direct involvement of bacteria that trigger inflammation and contribute to CRS pathogenesis. Staphylococcus aureus infection and persistence is associated with chronic
Dimitri Poddighe, Luca Vangelista
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Journal of Clinical and Translational Science, 2020 OBJECTIVES/GOALS: Non-alcoholic steatohepatitis (NASH) is a leading cause of cirrhosis in the world for which no anti-fibrotic therapies exist. We hypothesized that BMS-22 and maraviroc (MVC), chemokine receptor 2 (CCR2) and 5 (CCR5) antagonists ...
Annie J. Kruger +6 more
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Therapeutic efficacy and immunological response of CCL5 antagonists in models of contact skin reaction. [PDF]
PLoS ONE, 2010 Skin-infiltrating T-cells play a predominant role in allergic and inflammatory skin diseases such as atopic dermatitis, psoriasis and allergic contact dermatitis.
Miriam Canavese +2 more
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İstanbul Journal of PharmacyHuman immunodeficiency virus (HIV) infection is a major health problem worldwide. Antiretroviral Therapy (ART) involves a combination of HIV drugs (called HIV treatment regimen). However, ART resis5 tance, which emerged because of evolutionary processes,
Dilek Aksoy, Füsun Göktaş Ur
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Novel Approaches to Inhibit HIV Entry
Viruses, 2012 Human Immunodeficiency Virus (HIV) entry into target cells is a multi-step process involving binding of the viral glycoprotein, Env, to its receptor CD4 and a coreceptor—either CCR5 or CXCR4.
Chukwuka A. Didigu, Robert W. Doms
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Emerging Microbes and Infections, 2023 HIV-1 infection is mediated by a viral envelope subsequently binding to CD4 receptor and two main coreceptors, CCR5 (R5) for primary infection and CXCR4 (X4) in chronic infection.
Yueyang Yu +7 more
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AIDS Research and Therapy, 2012 Background CCR5 antagonists have clinically been approved for prevention or treatment of HIV/AIDS. Countries in Sub-Saharan Africa with the highest burden of HIV/AIDS are due to adopt these regimens.
Wambui Veronica +8 more
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