Results 71 to 80 of about 100,362 (261)

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Exploiting Temperature Effects for Robust Control and Reference Circuits Using Thin‐Film Contact‐Controlled Transistors

Advanced Electronic Materials, EarlyView.
Compact circuits based on contact‐controlled transistors are well‐suited to unsupervised thermal management, sensitive temperature measurement, or temperature‐stable current references. Demonstrated on flexible microcrystalline silicon and supported by simulation, the approach does not require supply voltage regulation, remains manufacturable across ...
Eva Bestelink, Jean‐Charles Fustec, Olivier de Sagazan, Rogier Fransen, George Bairaktatis, Emmanuel Jacques, Radu A. Sporea   +6 more
wiley   +1 more source

Current‐Driven Li2O Formation in Catalyst‐Free Solid‐State Li‐O2 Batteries Enabling Simultaneous High Energy and High Power

Advanced Energy Materials, EarlyView.
A catalyst‐free solid‐state Li‐O2 battery achieves current‐driven four‐electron Li2O formation, delivering simultaneous high‐energy and high‐power operation with 1032 Wh·kg−1 and 374 W·kg−1 in a single cell. ABSTRACT Li‐O2 batteries offer a compelling pathway toward next‐generation energy storage owing to their ultrahigh theoretical energy density ...
Shu‐Ting Ko, Ziting Ma, Cruz Gonsalves, Joseph Degroot, Chuck Chunhu Tan, Timothy Lin, Cauê Nogueira, Xin Xu, Chunting Chris Mi, Lingping Kong   +9 more
wiley   +1 more source

Beyond a number game: Flat team structures improve inclusion and performance in diverse scientific teams

Journal of the Association for Information Science and Technology, EarlyView.
Abstract The promises and perils about scientific team diversity are still debated in the scholarly literature, partly because the importance of underrepresented groups is not fully recognized or valued. In this paper, we summarize two perspectives on team diversity in science: horizontal differences and vertical disparity. Horizontal differences refer
Huimin Xu, Shujing Sun, Meijun Liu, Chenwei Zhang, Yi Bu, Yi Zhang, Daniel E. Acuna, Eric Meyer, Ying Ding   +8 more
wiley   +1 more source

IMPORTANCE OF PACHYMETRY IN DIAGNOSIS OF OPEN ANGLE GLAUCOMA

National Journal of Medical Research, 2013
Objective: The objective of the study was to establish relation between Central Corneal Thickness (CCT) and Intra-Occular Pressure (IOP) in Open Angle Glaucoma (OAG).
Dipak B Patel, J N Brambhatt, R N Kothari, Pooja Kumar, deependra Solanki, Diwakar Sharma   +5 more
doaj  

Comparative analysis of central corneal thickness in ocular hypertension and healthy individuals

Photodiagnosis and Photodynamic Therapy
Objective: This study aimed to compare the central corneal thickness (CCT) between patients with ocular hypertension (OHT) and healthy individuals, and to investigate the relationship between CCT and intraocular pressure (IOP), diopter, and corneal ...
Yu Zhang
doaj   +1 more source

Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia

BMEMat, EarlyView.
CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai, Rui Zhang, Haiyin Yang, Jiyue Xing, Tianyuan Hu, Mengxi Zhu, Rui Li, Xiaoli Chen, Beibei Zhao, Yang Lan, Stefan Barth, Yuanyu Huang, Li Zhang, Mengjie Zhang, Huining He   +14 more
wiley   +1 more source

Correlation of central corneal thickness and Goldmann applanation tonometry among Filipinos

Philippine Journal of Ophthalmology, 2004
Objective: To determine the distribution of central corneal thickness (CCT) among Filipinos and to correlate CCT with intraocular pressure (IOP). Methods: A prospective cross-sectional study was performed among Filipino patients consulting at the ...
Ma. Margarita L. Lat-Luna MD, Paul I. Guerrero, MD, John Vincent Policarpio D. Flores, MD, MS Epi   +2 more
doaj