Results 21 to 30 of about 396,460 (233)

Clinical and Molecular Characteristics of 60 Patients With Human Immunodeficiency Virus-Negative Castleman Disease

Frontiers in Immunology, 2022
Castleman disease (CD) is a rare lymphoproliferative disorder. The mechanistic target of rapamycin (mTOR) pathway is a key regulator of various cellular functions, which may be related with the potential mechanisms of CD occurrence.
Siyu Qian, Mengjie Ding, Huting Hou, Zeyuan Wang, Jieming Zhang, Yue Zhang, Meng Dong, Linan Zhu, Guannan Wang, Wencai Li, Xudong Zhang   +10 more
doaj   +1 more source

A head loss model for homogeneous slurry transport for medium sized particles

Journal of Hydrology and Hydromechanics, 2015
Slurry transport in horizontal and vertical pipelines is one of the major means of transport of sands and gravels in the dredging industry. There exist 4 main flow regimes, the fixed or stationary bed regime, the sliding bed regime, the heterogeneous ...
Miedema Sape A.
doaj   +1 more source

Study of Autoantibodies and DQ Antigens in Patient with Celiac Disease [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: Celiac Disease (CD) is a chronic autoimmune mediated disorder triggered by the ingestion of gluten. It is seen in genetically predisposed person and results in small intestine injury. Its aetiopathogenesis is not clear.
Andleeb Zehra, Usha, Richa Katiyar, Shailja Singh, Anju Bharti, Neeraj Kumar Agrawal, Om Prakash Mishra, Mohan Kumar   +7 more
doaj   +1 more source

Comparison of surgery rates in biologic-naïve patients with Crohn’s disease treated with vedolizumab or ustekinumab: findings from SOJOURN

BMC Gastroenterology, 2023
Background Crohn’s disease (CD) is a chronic inflammatory bowel disease characterized by relapsing and remitting inflammation that leads to progressive bowel damage.
Michelle Vu, Sabyasachi Ghosh, Kandavadivu Umashankar, Laura Weber, Christina Landis, Ninfa Candela, Benjamin Chastek   +6 more
doaj   +1 more source

A Multi-Objective Optimization Framework for Offshore Wind Farm Layouts and Electric Infrastructures

Energies, 2016
Current offshore wind farms (OWFs) design processes are based on a sequential approach which does not guarantee system optimality because it oversimplifies the problem by discarding important interdependencies between design aspects.
Silvio Rodrigues, Carlos Restrepo, George Katsouris, Rodrigo Teixeira Pinto, Maryam Soleimanzadeh, Peter Bosman, Pavol Bauer   +6 more
doaj   +1 more source

Wave-induced losses in offshore floating PV: Physics-based modelling, sensitivity-driven quantification, surrogate-model prediction, and design-guided mitigation strategies

Energy Conversion and Management: X
Offshore floating photovoltaics (OFPVs) emerge as a promising solution to overcome land constraints associated with inland renewable energy deployment. However, as OFPVs are still a developing technology, several performance-related uncertainties persist.
Sathya Shanka Vasuki, Jack Levell, Teddy Simanjuntak, Rudi Santbergen, Olindo Isabella   +4 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Gliadin peptides induce tissue transglutaminase activation and ER-stress through Ca2+ mobilization in Caco-2 cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Celiac disease (CD) is an intestinal inflammatory condition that develops in genetically susceptible individuals after exposure to dietary wheat gliadin.
Ivana Caputo, Agnese Secondo, Marilena Lepretti, Gaetana Paolella, Salvatore Auricchio, Maria Vittoria Barone, Carla Esposito   +6 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source