Results 31 to 40 of about 376,648 (197)

Expression of vascular endothelial growth factor and CD-31 in psoriasis

Asian Journal of Medical Sciences
Background: Psoriasis is a chronic inflammatory hyperproliferative skin disease. Increasing attention has been directed toward the role of skin microcirculation in its pathogenesis, with vascular endothelial growth factor (VEGF) implicated in ...
Swapnil Agarwal , Sangita Bohara , Gargi Tignath , Nita Khurana , Vijay Kumar Garg   +4 more
doaj   +1 more source

The immunohistochemical peculiarities of blood vessels during different forms of cancer of mammary glands [PDF]

Саратовский научно-медицинский журнал, 2010
The aim of this investigation was to study the peculiarities of the cancer of the mammary gland depending on its histogenesis, histological form, character of growth, degree of malignancy and stages of development on the postop-erational material.
Khidirov E.A.
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Pancreatic-specific autoantibodies to glycoprotein 2 mirror disease location and behaviour in younger patients with Crohn’s disease

BMC Gastroenterology, 2012
Background Glycoprotein 2 (GP2) was discovered as the major autoantigen of Crohn’s disease (CD)-specific pancreatic autoantibodies (PAB). We investigated anti-GP2 IgA and IgG antibodies as novel serological parameters in CD and assessed their association
Bogdanos Dimitrios P, Roggenbuck Dirk, Reinhold Dirk, Wex Thomas, Pavlidis Polychronis, von Arnim Ulrike, Malfertheiner Peter, Forbes Alastair, Conrad Karsten, Laass Martin W   +9 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Functional analysis of CAX2-like transporters isolated from two ecotypes of Sedum alfredii

Biologia Plantarum, 2016
Two genes encoding CAX2-like proteins were isolated from a Zn/Cd hyperaccumulating ecotype (HE) and nonhyperaccumulating ecotype (NHE) of Sedum alfredii Hance, and they were named SaCAX2h and SaCAX2n, respectively.
M. Zhang, J. Zhang, L. L. Lu, Z. Q. Zhu, X. E. Yang   +4 more
doaj   +1 more source

The genomic profiling and MAMLD1 expression in human and canines with Cushing’s disease

BMC Endocrine Disorders, 2021
Background Cushing’s disease (CD) is defined as hypercortisolemia caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas (corticotroph PA) that afflicts humans and dogs.
Andrew Wang, Stewart G. Neill, Scott Newman, Marianna A. Tryfonidou, Adriana Ioachimescu, Michael R. Rossi, Björn P. Meij, Nelson M. Oyesiku   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Integrated Hydrogen in Buildings: Energy Performance Comparisons of Green Hydrogen Solutions in the Built Environment

Buildings
This study investigates the integration of green hydrogen into building energy systems using local solar power, with the electricity grid serving as a backup plan.
Hamida Kurniawati, Siebe Broersma, Laure Itard, Saleh Mohammadi   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source