Functional imaging and circulating biomarkers of response to regorafenib in treatment-refractory metastatic colorectal cancer patients in a prospective phase II study [PDF]
, 2018 open32Regorafenib demonstrated efficacy in patients with metastatic colorectal cancer (mCRC). Lack of predictive biomarkers, potential toxicities and cost-effectiveness concerns highlight the unmet need for better patient selection.openKhan, Khurum; Rata,
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Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy. [PDF]
, 2016 BackgroundEstrogen pretreatment has been shown to attenuate the development of heart hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF).
Bopassa, Jean C +12 more
core +1 more source
Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants [PDF]
, 2011 Ovarian transplantation is one of the key approaches to restoring fertility in women who became menopausal as a result of cancer treatments. A major limitation of human ovarian transplants is massive follicular loss during revascularization.
Soleimani, Reza +2 more
core +6 more sources
The magnetic fields of hot subdwarf stars [PDF]
, 2012 Detection of magnetic fields has been reported in several sdO and sdB stars. Recent literature has cast doubts on the reliability of most of these detections.
Bagnulo +16 more
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A Multi-Objective Optimization Framework for Offshore Wind Farm Layouts and Electric Infrastructures
Energies, 2016 Current offshore wind farms (OWFs) design processes are based on a sequential approach which does not guarantee system optimality because it oversimplifies the problem by discarding important interdependencies between design aspects.
Silvio Rodrigues +6 more
doaj +1 more source
Conditional entropies and their relation to entanglement criteria [PDF]
, 2002 We discuss conditional Renyi and Tsallis entropies for bipartite quantum systems of finite dimension. We investigate the relation between the positivity of conditional entropies and entanglement properties. It is in particular shown that any state having
Vollbrecht, Karl Gerd H. +1 more
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Gliadin peptides induce tissue transglutaminase activation and ER-stress through Ca2+ mobilization in Caco-2 cells. [PDF]
PLoS ONE, 2012 BACKGROUND: Celiac disease (CD) is an intestinal inflammatory condition that develops in genetically susceptible individuals after exposure to dietary wheat gliadin.
Ivana Caputo +6 more
doaj +1 more source
The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer [PDF]
, 2005 <b>OBJECTIVE</b>: To test the hypothesis that angiogenesis in prostate cancer is associated with tumour invasion and metastasis, and that this is mediated through increased cyclooxygenase-2 (COX-2) expression.
Bartlett, J.M.S. +3 more
core +1 more source
Bioluminescence Imaging of Angiogenesis in a Murine Orthotopic Pancreatic Cancer Model [PDF]
, 2018 Purpose: Angiogenesis is essential for physiological processes as well as for carcinogenesis. New approaches to cancer therapy include targeting angiogenesis. One target is VEGF-A and its receptor VEGFR2.
Angst, Eliane +5 more
core
Results of the Childhood Cancer and Leukaemia Group's United Kingdom Relapsed Wilms Tumour Trial
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background The United Kingdom relapsed Wilms tumour (UKW‐R) trial aimed to improve the historically low survival rates after relapse of Wilms tumour (WT) through a prospective national risk‐stratified protocol. The trial also evaluated efficacy and toxicity of high‐dose melphalan.
Sucheta J. Vaidya +10 more
wiley +1 more source