Results 31 to 40 of about 1,288,874 (296)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Journal of Groundwater Science and Engineering, 2021 In order to explore the influence of rainfall on the release of heavy metal Cadmium (Cd) in soil in a coal-mining area,soil column leaching experiments were carried out by simulating 3 types of rainfall (acid rain,normal rainfall,and actual rainfall ...
Hao ZHOU +3 more
doaj +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
An evaluation of the efficiency of cultural plants to remove heavy metals from growing mediu
Plant, Soil and Environment, 2005 Contamination of heavy metals in the environment is one of major concern because of their toxicity and threat to human life and the environment. Phytoextraction, using plants to extract heavy metals from contaminated soils is an emerging technology.
R. Hajiboland
doaj +1 more source
Cd-regulated gene expression in Datura innoxia [PDF]
, 1992 The effects of Cd on the expression of specific proteins and transcripts have been examined in Cd-resistant (Cd300) and Cd-sensitive cultures of Datura innoxia. 2D PAGE analysis of the soluble fraction of D. innoxia protein proved problematic.
Urwin, P.E, Urwin, Peter Edward
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
The response of chamomile (Matricaria chamomilla L.) plants to soil zinc supply
Plant, Soil and Environment, 2006 A pot experiment was conducted to investigate the influence of varying supplies of Zn (50-150-300 mg/kg soil - Orthic Luvisol) on the uptake of Zn by plants, selected productive parameters and production of secondary metabolites in Matricaria chamomilla ...
A. Grejtovský +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source