Results 51 to 60 of about 1,681,353 (346)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Determination of Lead, Cadmium, Copper and Iron Contents in Water by Multi-walled Carbon Nanotubes-solid Phase Extraction

Yankuang ceshi, 2014
The traditional solid phase extraction sorbent contains certain deficiencies in the progress of processing heavy metals in environmental samples, such as pH instability and co-extraction difficulty.
SUN Na, CHI Xiao-feng, HU Feng-zu, YANG Yue-qin   +3 more
doaj  

Dielectric properties of some cadmium and mercury amino alcohol complexes at low temperatures [PDF]

Journal of the Serbian Chemical Society, 2002
The dielectric properties of some cadmium and mercury amino alcohol complexes were studied within the temperature range of 100–300 K at the frequencies of 100, 300 and 1000 kHz.
Masoud Mamdouh S., Hafez Ahmed M., Ramadan Sh.M., Ali A.E.   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Cds

, 2015
The Centre de Donnees de Strasbourg (CDS) is a reference data centre for Astronomy. The CDS services; SIMBAD, Vizier, Aladin and X-Match, provide added value to scientific content in order to support the astronomy research community. Data and information are curated from refereed journals, major surveys, observatories and missions with a strong ...
openaire   +2 more sources

Tandem quadruplication of HMA4 in the zinc (Zn) and cadmium (Cd) hyperaccumulator noccaea caerulescens [PDF]

, 2011
Zinc (Zn) and cadmium (Cd) hyperaccumulation may have evolved twice in the Brassicaceae, in Arabidopsis halleri and in the Noccaea genus. Tandem gene duplication and deregulated expression of the Zn transporter, HMA4, has previously been linked to Zn/Cd ...
King Graham J., Ó Lochlainn, Seosamh, Broadley, Martin R, John P. Hammond, Fray, R O, Bowen, H. C., Helen C Bowen, John P Hammond, Hammond, J P, Hammond, J. P., Lochlainn, Seosamh O., Philip J White, Neil S Graham, Graham J. King, Broadley, Martin R., Ó Lochlainn Seosamh, King, G. J., Hammond, John P., King, Graham J., O\u27Lochlainn, S, Broadley, M. R., Broadley Martin R., Bowen, Helen, Bowen Helen C., Helen C. Bowen, Martin R. Broadley, Martin R Broadley, White, P. J., Rupert G Fray, Graham, N. S., Neil S. Graham, Fray Rupert G., Philip J. White, White Philip J., Fray, R. G., Graham, N S, Rupert G. Fray, Graham, Neil S., King, G J, O Lochlainn, S., White, Philip J., Fray, Rupert G., Graham Neil S., Hammond John P., Bowen, Helen C., Seosamh Ó Lochlainn, Graham J King   +46 more
core   +1 more source

Pengaruh pH dalam Pengolahan Air Limbah Laboratorium Dengan Metode Adsorpsi untuk Penurunan Kadar Logam Berat Pb, Cu, dan Cd

Jurnal Ilmu Lingkungan, 2022
Air limbah laboratorium seharusnya tidak dibuang langsung ke lingkungan tanpa pengolahan lebih lanjut. Hal ini dapat menimbulkan pencemaran terhadap lingkungan yang dampaknya juga dirasakan oleh makhluk hidup di sekitarnya.
Novi Anggraini, Tuty Emilia Agustina, Fitri Hadiah   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Velocity dispersion functions of pressure-supported galaxies in EAGLE simulations with varying active galactic nucleus feedback

Astronomy & Astrophysics
We investigated the stellar velocity dispersion functions (VDFs) of pressure-supported galaxies in the EAGLE cosmological simulations. The central stellar velocity dispersion is one of the fundamental dynamical tracers of the total mass of galaxy ...
Choi Jungwon, Sohn Jubee
doaj   +1 more source

Determination of 14 Trace Elements in Geochemical Samples by ICP-MS Using Kinetic Energy Discrimination Mode

Yankuang ceshi, 2019
BACKGROUND Traditional inductively coupled plasma-mass spectrometry (ICP-MS) determination of trace elements such as Ag and Cd in geochemical samples is seriously affected by the matrix effect and multiple polyatomic ions, making it difficult to measure ...
XU Jin-li, XIING Xia, TANG Rui-ling, HU Meng-ying, ZHANG Peng-peng, BAI Jin-feng, ZHANG Qin   +6 more
doaj   +1 more source