Results 51 to 60 of about 1,256,023 (289)

AI-CD Nigeria Short Film

, 2023
Introduction of African Initiative for Combating Desertification to Strengthen Resilience to Climate Change in the Sahel and the Horn of Africa (AI-CD) and activities in Nigeria to combat ...
Secreatariat, AI-CD
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Determination of Lead, Cadmium, Copper and Iron Contents in Water by Multi-walled Carbon Nanotubes-solid Phase Extraction

Yankuang ceshi, 2014
The traditional solid phase extraction sorbent contains certain deficiencies in the progress of processing heavy metals in environmental samples, such as pH instability and co-extraction difficulty.
SUN Na, CHI Xiao-feng, HU Feng-zu, YANG Yue-qin   +3 more
doaj  

The Occurrences of Hg and Cd in Soils around Cities and Rivers and Their Ecological Risk Assessment

Yankuang ceshi, 2020
BACKGROUND The ecological risk of heavy metal anomaly in soil is widespread due to human activities and natural processes. Hg anomaly in urban soil and Cd anomaly along rivers are the typical cases.
MA Sheng-ming, ZHU Li-xin, TANG Li-ling, TANG Shi-xin   +3 more
doaj   +1 more source

The effectiveness of foliar applications of synthesized zinc-amino acid chelates and ZnSO4 on the nutritional status of wheat plant cultivated in a soil contaminated with Cd and diesel oil

International Archives of Health Sciences, 2021
Aims: This study was done to evaluate the effectiveness of foliar applications of synthesized zinc-amino acid chelates and ZnSO4 on the nutritional status of wheat plant in a soil contaminated with Cd and diesel oil.
Amir Hossein Baghaie, Mehran Keshavarzi
doaj   +1 more source

Cds

, 2015
The Centre de Donnees de Strasbourg (CDS) is a reference data centre for Astronomy. The CDS services; SIMBAD, Vizier, Aladin and X-Match, provide added value to scientific content in order to support the astronomy research community. Data and information are curated from refereed journals, major surveys, observatories and missions with a strong ...
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Velocity dispersion functions of pressure-supported galaxies in EAGLE simulations with varying active galactic nucleus feedback

Astronomy & Astrophysics
We investigated the stellar velocity dispersion functions (VDFs) of pressure-supported galaxies in the EAGLE cosmological simulations. The central stellar velocity dispersion is one of the fundamental dynamical tracers of the total mass of galaxy ...
Choi Jungwon, Sohn Jubee
doaj   +1 more source

Tandem quadruplication of HMA4 in the zinc (Zn) and cadmium (Cd) hyperaccumulator noccaea caerulescens [PDF]

, 2011
Zinc (Zn) and cadmium (Cd) hyperaccumulation may have evolved twice in the Brassicaceae, in Arabidopsis halleri and in the Noccaea genus. Tandem gene duplication and deregulated expression of the Zn transporter, HMA4, has previously been linked to Zn/Cd ...
King Graham J., Ó Lochlainn, Seosamh, Broadley, Martin R, John P. Hammond, Fray, R O, Bowen, H. C., Helen C Bowen, John P Hammond, Hammond, J P, Hammond, J. P., Lochlainn, Seosamh O., Philip J White, Neil S Graham, Graham J. King, Broadley, Martin R., Ó Lochlainn Seosamh, King, G. J., Hammond, John P., King, Graham J., O\u27Lochlainn, S, Broadley, M. R., Broadley Martin R., Bowen, Helen, Bowen Helen C., Helen C. Bowen, Martin R. Broadley, Martin R Broadley, White, P. J., Rupert G Fray, Graham, N. S., Neil S. Graham, Fray Rupert G., Philip J. White, White Philip J., Fray, R. G., Graham, N S, Rupert G. Fray, Graham, Neil S., King, G J, O Lochlainn, S., White, Philip J., Fray, Rupert G., Graham Neil S., Hammond John P., Bowen, Helen C., Seosamh Ó Lochlainn, Graham J King   +46 more
core   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source