Results 41 to 50 of about 645,588 (248)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Velocity dispersion functions of pressure-supported galaxies in EAGLE simulations with varying active galactic nucleus feedback

Astronomy & Astrophysics
We investigated the stellar velocity dispersion functions (VDFs) of pressure-supported galaxies in the EAGLE cosmological simulations. The central stellar velocity dispersion is one of the fundamental dynamical tracers of the total mass of galaxy ...
Choi Jungwon, Sohn Jubee
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Effects of pH on MICP curing of cadmium-contaminated tailings

Yantu gongcheng xuebao
The microbial induced calcium carbonate precipitation (MICP) method is regarded as an environmentally sustainable approach for the solidification and remediation of contaminated soils.
JIANG Zhaoming1 , CHEN Yonggui1 , WEN Zihao1, FU Jun1, 2, ZHOU Han2
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cosmology with supernova Encore in the strong lensing cluster MACS J0138–2155

Astronomy & Astrophysics
Robust mass modeling of strong-lensing galaxy clusters is crucial for studying cosmology and galaxy evolution. We present and compare seven mass models of the galaxy cluster MACS J0138−2155, constructed using six independent modeling software programs ...
Suyu S. H., Acebron A., Grillo C., Bergamini P., Caminha G. B., Cha S., Diego J. M., Ertl S., Foo N., Frye B. L., Fudamoto Y., Granata G., Halkola A., Jee M. J., Kamieneski P. S., Koekemoer A. M., Meena A. K., Newman A. B., Nishida S., Oguri M., Rosati P., Schuldt S., Zitrin A., Cañameras R., Hayes E. E., Larison C., Mamuzic E., Millon M., Pierel J. D. R., Tortorelli L., Wang H.   +30 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Genetic and immunological markers of the formation of metabolic syndrome in schoolchildren (on the example of the Perm Region)

Якутский медицинский журнал
The problem of the formation of metabolic syndrome in children is becoming more and more urgent every year, which is associated with excess nutrition, physical inactivity, increased psycho-emotional stress, therefore, timely identification of immune and ...
N. V. Zaitseva, O. A. Kazakova, A. A. Mazunina, V. B. Alekseev, O. V. Dolgikh   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

DeepDive: A deep dive into the physics of the first massive quiescent galaxies in the Universe

Astronomy & Astrophysics
We present the DeepDive program, in which we obtained deep (1 − 3 hours) JWST/NIRSpec G235M/F170LP spectra for ten primary massive (log(M★/M⊙) = 10.8 − 11.5) quiescent galaxies at z ∼ 3 − 4.
Ito K., Valentino F., Brammer G., Hamadouche M. L., Whitaker K. E., Kokorev V., Zhu P., Kakimoto T., Wu P.-F., Antwi-Danso J., Baker W. M., Ceverino D., Faisst A. L., Farcy M., Fujimoto S., Gallazzi A., Gillman S., Gottumukkala R., Heintz K. E., Hirschmann M., Jespersen C. K., Kubo M., Lee M., Magdis G., Onodera M., Shimakawa R., Tanaka M., Toft S., Weaver J. R.   +28 more
doaj   +1 more source