Results 61 to 70 of about 1,681,353 (346)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Knockout of OsNramp5 using the CRISPR/Cas9 system produces low Cd-accumulating indica rice without compromising yield

Scientific Reports, 2017
Rice grain with excessive cadmium (Cd) is a major source of dietary Cd intake and a serious threat to health for people who consume rice as a staple food.
Li Tang, Bigang Mao, Yaokui Li, Qiming Lv, Liping Zhang, Caiyan Chen, Hanjie He, Weiping Wang, Xiongfeng Zeng, Y. Shao, Yinlin Pan, Yuan-yi Hu, Yan Peng, Xiqin Fu, Hongqing Li, S. Xia, Bingran Zhao   +16 more
semanticscholar   +1 more source

Effects of pH on MICP curing of cadmium-contaminated tailings

Yantu gongcheng xuebao
The microbial induced calcium carbonate precipitation (MICP) method is regarded as an environmentally sustainable approach for the solidification and remediation of contaminated soils.
JIANG Zhaoming1 , CHEN Yonggui1 , WEN Zihao1, FU Jun1, 2, ZHOU Han2
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Cosmology with supernova Encore in the strong lensing cluster MACS J0138–2155

Astronomy & Astrophysics
Robust mass modeling of strong-lensing galaxy clusters is crucial for studying cosmology and galaxy evolution. We present and compare seven mass models of the galaxy cluster MACS J0138−2155, constructed using six independent modeling software programs ...
Suyu S. H., Acebron A., Grillo C., Bergamini P., Caminha G. B., Cha S., Diego J. M., Ertl S., Foo N., Frye B. L., Fudamoto Y., Granata G., Halkola A., Jee M. J., Kamieneski P. S., Koekemoer A. M., Meena A. K., Newman A. B., Nishida S., Oguri M., Rosati P., Schuldt S., Zitrin A., Cañameras R., Hayes E. E., Larison C., Mamuzic E., Millon M., Pierel J. D. R., Tortorelli L., Wang H.   +30 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The efficacy of mindfulness- based intervention on self- control and high- risk behaviors in ADHD with CD adolescents

مجله علوم روانشناختی, 2022
Background: Numerous studies have examined the effectiveness of mindfulness-based intervention in people with attention deficit hyperactivity disorder.
afsoun golestaneh, masoud mohammadi, azam davoodi, najmeh fath   +3 more
doaj