Emerging Roles of PSTPIP2 in Autoimmunity: From Mechanism to Therapeutic Implications
PSTPIP2 acts as a key brake on myeloid inflammation by suppressing IL‐1β‐driven signalling, macrophage dysregulation and inflammation‐associated bone remodelling. Its emerging roles in CRMO/CMO, rheumatoid arthritis, SAPHO syndrome and bullous pemphigoid support its potential as a biomarker and therapeutic target.
Erdong Zhang +9 more
wiley +1 more source
CD14<sup>+</sup>CD16<sup>+</sup> monocyte-derived TREM2 macrophages promote lung fibrosis in systemic sclerosis-interstitial lung disease. [PDF]
Kim JY, Kim YJ, Lee SJ.
europepmc +1 more source
Acinetobacter baumannii lipooligosaccharide core region promotes CD14-dependent TLR4 endocytosis and enhances pathogenicity through interferon-β production. [PDF]
Lee YT +9 more
europepmc +1 more source
Delayed late ventricular depolarization is associated with inflammation in epicardial Fat Among females: a New avenue in cardiac electrophysiology. [PDF]
Ahmed NA +10 more
europepmc +1 more source
Biomimetic Virus-Like Mesoporous Silica Nanoparticles Activate NK Cells Indirectly via Monocyte Crosstalk. [PDF]
Sivonen M +10 more
europepmc +1 more source
Author Correction: Peripheral blood CD14 + monocytes in luminal breast carcinoma subtypes: in preliminary research and overview of candidate biomarker proteins. [PDF]
Alexovič M +9 more
europepmc +1 more source
Related searches:
In addition to its role as a mediator of innate pro-inflammatory responses following bacterial lipopolysaccharide (LPS) binding, the 55kDa glycosyl-phosphatidylinositol-linked macrophage plasma membrane glycoprotein CD14 is now also known to play a role in phagocytic clearance of apoptotic cells.
C D, Gregory, A, Devitt
openaire +2 more sources
Following the analysis of flow cytometry data on ovine and bovine cells and immunoprecipitation, immunohistochemistry and competitive binding studies, a cluster of three monoclonal antibodies (mAbs) (VPM65, VPM66 and VPM67) appeared to be specific for the ruminant CD14 (Gupta, V.K., McConnell, I., Dalziel, R.G. and Hopkins, J., 1996.
Berthon, Patricia, Hopkins, Julie
openaire +3 more sources
The GPI-anchored 55 kDa glycoprotein CD14 is expressed on monocytes/macrophages and to a lesser extent on granulocytes. Engagement of CD14 by ligands like lipopolysaccharide, intact bacteria or apoptotic cells can result in either pro- or anti-inflammatory responses.
openaire +2 more sources

