Results 81 to 90 of about 131,028 (295)

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

The role of CD14 in the pathogenesis of rheumatoid arthritis

Клинический разбор в общей медицине
Objective. To identify a possible correlation between the concentration of sCD14 and the severity of rheumatoid arthritis, to determine its role in the pathological process. Material and methods. The literature review includes an analysis of scientific
Vitaly B. Kaliberdenko, Andrey V. Petrov, Alexander A. Gorlov, Emiliya R. Zagidullina, Tatiana S. Pronkina, Ekaterina S. Gorbenko, Darya I. Bachalova, Amina I. Batkaeva   +7 more
doaj   +1 more source

Genes differentially expressed in CD14⁺Tie2⁺ and CD14⁺Tie2⁻ or total CD14⁺ cells (CD14⁺ tot).

, 2016
Genes differentially expressed in CD14+Tie2+ and CD14+Tie2− or total CD14+ cells (CD14+ tot).
Paolo Catarsi (325689), Silvia Salmoiraghi (2826902), Paola Guglielmelli (278489), Vittorio Abbonante (2826911), Giovanni Barosi (325686), Benedetta Gaia Erba (2826920), Vittorio Rosti (133339), Basilio Jemos (2826908), Gabriela Fois (2826905), Margherita Massa (133323), Valentina Poletto (325692), Alessandra Balduini (287103), Rita Campanelli (325687), Alessandra Iurlo (2826914), Laura Villani (10719), Christian Andrea Di Buduo (2826917), Luigi Maddaluno (441408)   +16 more
core   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

DataSheet_1_Elevated Fibronectin Levels in Profibrotic CD14+ Monocytes and CD14+ Macrophages in Systemic Sclerosis.pdf

, 2021
BackgroundSystemic sclerosis (SSc) is an autoimmune disease characterized by overproduction of extracellular matrix (ECM) and multiorgan fibrosis. Animal studies pointed to bone marrow-derived cells as a potential source of pathological ECM-producing ...
Michał Rudnik (11322828), Oliver Distler (36405), Amela Hukara (11322831), Vincent Milleret (3339153), Suzana Jordan (161630), Gabriela Kania (75917), Martin Ehrbar (101942), Carol Feghali-Bostwick (270228), Karin Klingel (65760), Przemysław Błyszczuk (11322837), Ievgeniia Kocherova (11322834), Janine Schniering (4048954)   +11 more
core   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Research note: Turkey (Meleagris gallopavo) semen CD14+ macrophages – management, key features, and classification – a pilot study with optimized protocols

Poultry Science
Semen macrophages (Mф) play a role in mediating innate immune responses and supporting adaptive immunity within the male reproductive tract. Knowledge about the semen Mф in avian species remains limited.
Ewa M. Drzewiecka, Anna Szóstek-Mioduchowska, Joanna Wiśniewska, Ewa Liszewska, Mariola Słowińska   +4 more
doaj   +1 more source

The anti-inflammatory effect of combined complement and CD14 inhibition is preserved during escalating bacterial load

, 2015
Combined inhibition of complement and CD14 is known to attenuate bacterial-induced inflammation, but the dependency of the bacterial load on this effect is unknown. Thus, we investigated whether the effect of such combined inhibition on Escherichia coli-
Thorgersen, Ebbe Billmann, Mollnes, Tom Eirik, Egge, Kjetil Hagene, Barratt-Due, Andreas, Pharo, Anne Margrethe, Lau, Corinna, Lindstad, Julie Katrine, Nymo, Stig Haugset, Espevik, Terje   +8 more
core   +1 more source

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source