Results 61 to 70 of about 131,028 (295)

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Expression of immune-associated genes in isolated classical monocytes in preeclampsia

RUDN Journal of Medicine
Relevance. Preeclampsia is a severe complication of pregnancy, occurring in 8 % of cases and causing high maternal and perinatal mortality and morbidity.
Polina A. Vishnyakova, Viktoriia V. Kiseleva, Anastasiya S. Poltavets, V. E. Karyagina, Aida A. Bagdasarian, Evgeny N. Knyazev, Kamilla T. Muminova, Zulfiya S. Khodzhaeva, Andrey V. Elchaninov, Gennady T. Sukhikh   +9 more
doaj   +1 more source

The LPS receptor, CD14, in experimental autoimmune encephalomyelitis and multiple sclerosis [PDF]

, 2006
Innate immune receptors are crucial for defense against microorganisms. Recently, a cross-talk between innate and adaptive immunity has been considered. Here, we provide first evidence for a role of the key innate immune receptor, LPS receptor (CD14) in ...
Letiembre, Maryse, Engelhardt, B., Doering, Axinia, Wenlin Hao, Hao, W. L., Doering, A., Yang Liu, Fassbender, Klaus, Bernreuther, Christian, Walter, Silke, Klaus Fassbender, Axinia Doering, Maryse Letiembre, Markus Glatzel, Christian Bernreuther, Diem, Ricarda, Walter, S., Engelhardt, Britta, Liu, Yang, Liu, Y., Britta Engelhardt, Ricarda Diem, Silke Walter, Glatzel, Markus, Hao, Wenlin   +24 more
core   +2 more sources

Expression and regulation of macrophage-inducible C-type lectin in human synovial macrophages

Central European Journal of Immunology, 2021
Recent evidence suggests that synovial macrophage activation may be involved in cartilage destruction and pain in osteoarthritis (OA). The macrophage-inducible C-type lectin (Mincle) Clec4e is expressed in macrophages and is regulated in inflammatory ...
Mitsutoshi Moriya, Kentaro Uchida, Shotaro Takano, Dai Iwase, Gen Inoue, Manabu Muaki, Ryo Tazawa, Jun Aikawa, Hiroyuki Sekiguchi, Masashi Takaso   +9 more
doaj   +1 more source

Establishment of the cell line, HeLa-CD14, transfected with the human CD14 gene

Oncology Letters, 2012
CD14 is the pivotal molecule in the diagnosis and therapy of CD14-associated diseases, and is important in bacteremia. The HeLa cell line is regarded as immortal due to its prolific character. The HeLa cell line is derived from human cervical cancer cells and has been widely used in cancer research and gene transfection.
Bo-Tao, Ning, Yong-Min, Tang
openaire   +3 more sources

Soluble CD14 and fracture risk [PDF]

Osteoporosis International, 2015
Soluble CD14 (sCD14) is an inflammatory marker associated with osteoclasts. Using Cox proportional hazards models, we found a positive association between plasma levels of sCD14 and risk of incident fracture among participants in the Cardiovascular Health Study.
Bethel, M, Bůžková, P, Fink, HA, Robbins, JA, Cauley, JA, Lee, J, Barzilay, JI, Jalal, DI, Carbone, LD   +8 more
openaire   +4 more sources

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

The effect of alcohol on the differential expression of cluster of differentiation 14 gene, associated pathways, and genetic network. [PDF]

PLoS ONE, 2017
Alcohol consumption affects human health in part by compromising the immune system. In this study, we examined the expression of the Cd14 (cluster of differentiation 14) gene, which is involved in the immune system through a proinflammatory cascade ...
Diana X Zhou, Yinghong Zhao, Jessica A Baker, Qingqing Gu, Kristin M Hamre, Junming Yue, Byron C Jones, Melloni N Cook, Lu Lu   +8 more
doaj   +1 more source

Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis [PDF]

, 2004
Streptococcus uberis and Serratia marcescens are Gram-positive and Gram-negative bacteria, respectively, that induce clinical mastitis. Once initial host barrier systems have been breached by these pathogens, the innate immune system provides the next ...
Bannerman, Douglas, Goff, JP, Goff, Jesse P, Lippolis, JD, John D. Lippolis, Paape, Max, Bannerman, Douglas D, Paape, Max J, Kimura, K, Jayne C. Hope, Hope, Jayne C, Kimura, Kayoko, Lippolis, John D, Douglas D. Bannerman, Max J. Paape, Lippolis, John, Hope, Jayne, Kayoko Kimura, Hope, Jayne; id_orcid, Jesse P. Goff, Goff, Jesse   +20 more
core   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source