Results 51 to 60 of about 131,028 (295)

The Inflammatory Response Induced by Aspergillus fumigatus Conidia Is Dependent on Complement Activation: Insight from a Whole Blood Model

Journal of Innate Immunity
Introduction: We aimed to elucidate the inflammatory response of Aspergillus fumigatus conidia in a whole-blood model of innate immune activation and to compare it with the well-characterized inflammatory reaction to Escherichia coli.
Beatrice Fageräng, Maximilian Peter Götz, Leon Cyranka, Corinna Lau, Per H. Nilsson, Tom Eirik Mollnes, Peter Garred   +6 more
doaj   +1 more source

Serum CD14 concentration is associated with obesity and insulin resistance in non-diabetic individuals

Journal of International Medical Research, 2022
Objective CD14 is a lipopolysaccharide-binding protein that serves as a marker of monocytes. The role of circulating CD14 in patients with obesity without diabetes remains unknown. Here, we characterized the relationships between serum CD14 concentration
Yea Eun Kang, Kyong Hye Joung, Ji Min Kim, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku   +5 more
doaj   +1 more source

Role of p52 (NF-κB2) in LPS tolerance in a human B cell line [PDF]

, 1999
Cells of the weakly CD14 positive human B cell line RPMI 8226, clone 1, will mobilize NF-κB (p50/p65 and p50/p50) proteins and produce TNF mRNA when stimulated with lipopolysaccharide (LPS), When such cells are precultured with a low amount of LPS (50 ...
Wedel, Angela, Sulski, Gabi, Kuprash, Dmitry, H.W. Loems Ziegler-Heitbrock, Angela Wedel, Marion Frankenberger, Irmhild Petersmann, Nedospasov, Sergei, Frankenberger, Marion, Petersmann, Irmhild, Ziegler-Heitbrock, H. W. Loems, Dmitry Kuprash, Sergei Nedospasov, Gabi Sulski   +13 more
core   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Unravelling the anti-inflammatory mechanisms of dietary fatty acids [PDF]

, 2009
Polyunsaturated fatty acids (PUFA) have been shown to modulate immune responses and have therapeutic effects in inflammatory disorders. The specific mechanisms of their actions have yet to be defined.
Dowling, Jennifer K.
core   +2 more sources

Role of CD14 in a mouse model of acute lung inflammation induced by different lipopolysaccharide chemotypes. [PDF]

PLoS ONE, 2010
BACKGROUND: Recognition of lipopolysaccharide (LPS) is required for effective defense against invading gram-negative bacteria. Recently, in vitro studies revealed that CD14 is required for activation of the myeloid differentiation factor (MyD)88 ...
Adam A Anas, Joppe W R Hovius, Cornelis van 't Veer, Tom van der Poll, Alex F de Vos   +4 more
doaj   +1 more source

Plasma Soluble CD14 Subtype Levels Are Associated With Clinical Outcomes in Critically Ill Subjects With Coronavirus Disease 2019

Critical Care Explorations, 2021
IMPORTANCE:. In bacterial sepsis, CD14 and its N-terminal fragment (soluble CD14 subtype, “Presepsin”) have been characterized as markers of innate immune responses and emerging evidence has linked both to coronavirus disease 2019 pathophysiology ...
F. Linzee Mabrey, MD, Eric D. Morrell, MD, Pavan K. Bhatraju, MD, MSc, Neha A. Sathe, MD, Sana S. Sakr, PhD, Sharon K. Sahi, BS, T. Eoin West, MD, MPH, Carmen Mikacenic, MD, Mark M. Wurfel, MD, PhD   +8 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Effects of hepatocyte CD14 upregulation during cholestasis on endotoxin sensitivity. [PDF]

PLoS ONE, 2012
Cholestasis is frequently related to endotoxemia and inflammatory response. Our previous investigation revealed a significant increase in plasma endotoxin and CD14 levels during biliary atresia.
Ming-Huei Chou, Jiin-Haur Chuang, Hock-Liew Eng, Po-Chin Tsai, Chih-Sung Hsieh, Hsiang-Chun Liu, Chiou-Huey Wang, Chih-Yun Lin, Tsun-Mei Lin   +8 more
doaj   +1 more source