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Cancers, 2021 CAR-T cell therapy is not without some clinical adverse effects, namely cytokine storms, due to a massive release of cytokines when CAR-T cells multiply in the body.
Shabirul Haque
exaly +2 more sources
Retargeting CD19 Chimeric Antigen Receptor T Cells via Engineered CD19-Fusion Proteins
Molecular Pharmaceutics, 2019 CD19-targeted chimeric antigen receptor (CAR) T-cells (CAR19s) show remarkable efficacy in the treatment of relapsed/refractory acute lymphocytic leukemia and Non-Hodgkin’s lymphoma.
Paul D Rennert +2 more
exaly +2 more sources
Diphtheria toxin-based anti-human CD19 immunotoxin for targeting human CD19+ tumors
Molecular Oncology, 2017 CD19 is expressed on normal and neoplastic B cells and is a promising target for immunotherapy. However, there is still an unmet need to further develop novel therapeutic drugs for the treatment of the refractory/relapsing human CD19+ tumors.
David H Sachs +2 more
exaly +2 more sources
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Characterization of porcine CD19 and anti-CD19 monoclonal antibodies
Molecular Immunology, 2004CD19 is an important pan B cell marker and co-stimulatory protein in humans and mice. Efforts to further characterize B cell ontogeny in swine have been hampered by the lack of monoclonal antibodies (mAb) to valuable surface markers like Vpre-B, CD19, CD34 and CD43.
Jishan, Sun +4 more
openaire +2 more sources
Deficiencies in the CD19 complex
Clinical Immunology, 2018Signaling via the CD19-complex, consisting of CD19, CD81, CD21 and CD225, is critically important for B-cell development, differentiation and maturation. In this complex, each protein has its own distinct function. Over the past decade, 15 patients with antibody deficiency due to deficiencies in the CD19-complex have been described. These patients have
Marjolein W.J. Wentink +4 more
openaire +5 more sources
CD19 Deficiency Due to Genetic Defects in the CD19 and CD81 Genes
2018CD19 is a transmembrane protein specifically expressed on B cells and acts together with CD21, CD81, and CD225 to reduce the threshold for B-cell antigen receptor (BCR) signaling. To date, 11 patients with childhood-onset hypogammaglobulinemia have been identified with CD19 deficiency due to mutations in the CD19 or CD81 genes.
Menno C. van Zelm, Ismail Reisli
openaire +1 more source
Immunology Letters, 2017
As a 95-kDa member of the immunoglobulin super-family expressed exclusively on B lymphocytes, CD19 is a critical co-receptor for B cell antigen receptor (BCR) signal transduction. Co-ligation of CD19 with the BCR synergistically enhances calcium release, mitogen-activated protein kinase activity and cell proliferation.
Xinchen, Li +6 more
openaire +2 more sources
As a 95-kDa member of the immunoglobulin super-family expressed exclusively on B lymphocytes, CD19 is a critical co-receptor for B cell antigen receptor (BCR) signal transduction. Co-ligation of CD19 with the BCR synergistically enhances calcium release, mitogen-activated protein kinase activity and cell proliferation.
Xinchen, Li +6 more
openaire +2 more sources
The Journal of Immunology, 1997
Abstract Establishing signal transduction thresholds that regulate B lymphocyte responses to foreign Ags and tolerance to self Ags is critical for humoral immune responses. The effects of altered signaling thresholds in B lymphocytes were examined in CD19-deficient mice and transgenic mice that expressed human CD19 at varying ...
S, Sato +3 more
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Abstract Establishing signal transduction thresholds that regulate B lymphocyte responses to foreign Ags and tolerance to self Ags is critical for humoral immune responses. The effects of altered signaling thresholds in B lymphocytes were examined in CD19-deficient mice and transgenic mice that expressed human CD19 at varying ...
S, Sato +3 more
openaire +2 more sources