Results 181 to 190 of about 14,609 (214)

S100-Negative, CD1a-Positive Cutaneous Histiocytosis in a Patient with S100-Positive, CD1a-Positive Pulmonary Histiocytosis

The American Journal of Dermatopathology, 2015
In the diagnostic approach to histiocytic proliferations, immunohistochemistry may be a source of both confusion and clarification. We present a case of a 60-year-old man with a generalized pruritic eruption that demonstrated positive staining for CD1a, but negative staining for langerin and S100 protein.
Lisa, Mask-Bull, Neil A, Crowson, Andrew, John, Neal A, Mask   +3 more
openaire   +2 more sources

Immunolocalization of CD1a expressing dendritic cells in sinonasal polyposis

Journal of Immunoassay and Immunochemistry, 2022
Sinonasal polyps are benign projections of edematous nasal mucosa lined by respiratory epithelium. Langerhans cells (LCs) belonging to the dendritic cell family located in respiratory epithelium are involved in antigen presentation and maintenance of local immunological homeostasis.
Rachel Jayasekhar, John Kandam Kulathu Mathew, Zorem Sangi, Sam David Marconi, Vedantam Rupa, Suganthy Rabi   +5 more
openaire   +2 more sources

CD1a-mediated immunity from a molecular perspective

Molecular Immunology, 2023
Human CD1a is a non-polymorphic glycoprotein that presents lipid antigens to T cells. The most obvious role of CD1a is associated with its expression on Langerhans cells in epidermis, where it is involved in responses to pathogens. Antigen-specific T cells are believed to co-recognise CD1a presenting bacterial antigens such as species of lipopeptides ...
openaire   +2 more sources

CD1a-Expressing Monocytes as Mediators of Inflammation in Ulcerative Colitis [PDF]

Inflammatory Bowel Diseases, 2018
CD1a-expressing CD14+ monocytes have been identified as inducers of autoreactive T cells. In this study, the link between inflammatory and metabolic signals and CD1a-expressing monocytes in vitro and in vivo was examined, and CD1a was evaluated as a potential therapeutic target for treatment of ulcerative colitis (UC).Peripheral blood mononuclear cells
Florian Beigel, Eckhard Wolf, Matthias Siebeck   +2 more
exaly   +3 more sources

Structural characterization of two CD1A allelic variants

Human Immunology, 2001
CD1 molecules are specialized in presenting lipidic antigens to T lymphocytes. They are structurally and evolutionary related to MHC molecules and show very limited polymorphism. We have previously described and partially characterized a new human CD1A allele differing from the wild type CD1A by a substitution of Cysteine by Tryptophan at position 52 ...
M, Oteo, P, Arribas, F, Setién, J F, Parra, I, Mirones, M, Gómez del Moral, E, Martínez-Naves   +6 more
openaire   +2 more sources

Functional and Phenotypic Analysis of Thymic CD34+CD1a− Progenitor-Derived Dendritic Cells: Predominance of CD1a+ Differentiation Pathway

The Journal of Immunology, 1999
Abstract Whether thymic dendritic cells (DC) are phenotypically and functionally distinct from the monocyte lineage DC is an important question. Human thymic progenitors differentiate into T, NK, and DC. The latter induce clonal deletion of autoreactive thymocytes and therefore might be different from their monocyte-derived ...
A H, Dalloul, C, Patry, J, Salamero, B, Canque, F, Grassi, C, Schmitt   +5 more
openaire   +2 more sources

Induction of the CD1a Langerhans cell marker on human monocytes

Archives of Oral Biology, 1995
Monocytes have recently been recognized as a precursor of Langerhans cells. This study examined the regulatory influence of the epithelial environment on the putative first step of the transition towards a Langerhans cell phenotype--the induction of CD1a antigen.
Athanasasplatsis, S, Savage, NW, Winning, TA, Walsh, LJ   +3 more
openaire   +5 more sources

Analysis of CD1a-Positive Monocyte-Derived Cells in the Regional Lymph Nodes of Patients with Gallbladder Cancer

International Journal of Molecular Sciences
Dendritic cells (DCs) are known to be major antigen-presenting cells, and lymph nodes (LNs) play an important role in DC-mediated immune response. CD1a is known as a marker of monocyte-derived DCs.
Keita Kai, Tomokazu Tanaka, Takao Ide
exaly   +2 more sources

CD1a, CD1b, and CD1c in Immunity Against Mycobacteria

2013
The CD1 system is composed of five types of human CD1 proteins, CD1a, CD1b, CD1c, CD1d, and CD1e, and their mammalian orthologs. Each type of CD1 protein has a distinct antigen binding groove and shows differing patterns of expression within cells and in different tissues.
van Rhijn, I., Ly, D, Branch Moody, D.
openaire   +3 more sources

Cleavage of Langerhans cell surface CD1a molecule by trypsin

Research in Immunology, 1989
The T-cell surface differentiation antigens expressed on cortical thymocytes are composed of 3 molecules, CD1a (Mr 49,000), CD1b (Mr 45,000), and CD1c (Mr 43,000), which are non-covalently attached to beta 2-microglobulin. In the present study, differences in quantitative binding (immunogold labelling) were observed with four CD1a monoclonal antibodies
C, Dezutter-Dambuyant, D, Schmitt, M J, Staquet, L, Boumsell, J, Thivolet   +4 more
openaire   +2 more sources