Results 181 to 190 of about 21,316 (223)
An Unusual Case of Cutaneous Langerhans Cell Sarcoma Lacking S100 Expression: A Case Report and Review of the Literature. [PDF]
J Cutan PatholObid R +8 more
europepmc +1 more source
CD1a on Langerhans cells controls inflammatory skin disease [PDF]
Nature Immunology, 2016 CD1a is a lipid-presenting molecule that is abundantly expressed on Langerhans cells. However, the in vivo role of CD1a has remained unclear, principally because CD1a is lacking in mice. Through the use of mice with transgenic expression of CD1a, we found that the plant-derived lipid urushiol triggered CD1a-dependent skin inflammation driven by CD4 ...
Ji Hyung Kim, Yu Hu, Jerome Le Nours
exaly +7 more sources
Molecular Mechanism of Lipopeptide Presentation by CD1a [PDF]
Immunity, 2005 CD1a is expressed on Langerhans cells (LCs) and dendritic cells (DCs), where it mediates T cell recognition of glycolipid and lipopeptide antigens that contain either one or two alkyl chains. We demonstrate here that CD1a-restricted T cells can discriminate the peptide component of didehydroxymycobactin lipopeptides.
Dirk M Zajonc +2 more
exaly +4 more sources
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Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a
Nature Immunology, 2022Expressed on epidermal Langerhans cells, CD1a presents a range of self-lipid antigens found within the skin; however, the extent to which CD1a presents microbial ligands from bacteria colonizing the skin is unclear. Here we identified CD1a-dependent T cell responses to phosphatidylglycerol (PG), a ubiquitous bacterial membrane phospholipid, as well as ...
Gwennaelle C Monnot +2 more
exaly +3 more sources
Pathology International, 2008
According to the World Health Organization classification, neoplasms with perivascular epithelioid cell differentiation (PEComas) are mesenchymal tumors composed of histologically and immunohistochemically distinctive PEC. Generally, nearly all PEComas have immunoreactivity for both melanocytic (HMB‐45 and/or melan A) and smooth muscle (actin (SMA) and/
Yoshin, Adachi +8 more
openaire +2 more sources
According to the World Health Organization classification, neoplasms with perivascular epithelioid cell differentiation (PEComas) are mesenchymal tumors composed of histologically and immunohistochemically distinctive PEC. Generally, nearly all PEComas have immunoreactivity for both melanocytic (HMB‐45 and/or melan A) and smooth muscle (actin (SMA) and/
Yoshin, Adachi +8 more
openaire +2 more sources
CD1a and antitumour immune response
Immunology Letters, 2004Primary immune response is based on the capacity of local professional antigen-presenting cells (whose prototype is represented by dendritic cells, DCs) to take up and present antigens to selected clones of T cells, but also to non-specific effector cells such as macrophages or natural killer cells.
LA ROCCA, Giampiero +5 more
openaire +3 more sources
CD1a-Positive Cells in Odontogenic Cysts
Journal of Endodontics, 2002Langerhans cells (LC) are bone marrow-derived cells that have a CD1a-positive immunophenotype and are an important portion of the cell-mediated immune response. The aim of this study was an immunohistochemical evaluation of CD1a positive cells in different types of oral cysts.
PIATTELLI, Adriano +3 more
openaire +2 more sources
CD1a-mediated immunity from a molecular perspective
Molecular Immunology, 2023Human CD1a is a non-polymorphic glycoprotein that presents lipid antigens to T cells. The most obvious role of CD1a is associated with its expression on Langerhans cells in epidermis, where it is involved in responses to pathogens. Antigen-specific T cells are believed to co-recognise CD1a presenting bacterial antigens such as species of lipopeptides ...
openaire +2 more sources
Anti-CD1a antibody reduces inflammation in psoriasis
Nature Reviews Drug Discovery, 2016Megan Cully
exaly +2 more sources