Results 211 to 220 of about 143,709 (342)
Artificial intelligence streamlines scientific discovery of drug–target interactions
Abstract Drug discovery is a complicated process through which new therapeutics are identified to prevent and treat specific diseases. Identification of drug–target interactions (DTIs) stands as a pivotal aspect within the realm of drug discovery and development. The traditional process of drug discovery, especially identification of DTIs, is marked by
Yuxin Yang, Feixiong Cheng
wiley +1 more source
Dual-mode microfluidic immunostaining device for diagnostic biomarkers detection and tumor microenvironment evaluation. [PDF]
Zhang Y +6 more
europepmc +1 more source
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich +7 more
wiley +1 more source
Cure of a CD20-positive peripheral T-cell lymphoma-NOS with CHOPE regimen plus surgery a case report and literature review. [PDF]
Chi C, Wang S, Xu M, Shi Y, Ran X.
europepmc +1 more source
We described the prognostic impacts of mitochondrial status after neoadjuvant chemotherapy and its association with the tumor microenvironment in esophageal squamous cell carcinoma patients. High Mito‐score after NAC identifies ESCC patients with significantly poorer survival, particularly among those with advanced pathological stages, thereby possibly
Kotaro Sugawara +8 more
wiley +1 more source
Combined Anti-CD20/Anti-CD38 Therapy in Posttransplant Focal Segmental Glomerulosclerosis Recurrence: A Retrospective, International, Multicenter Study. [PDF]
Cravedi P +26 more
europepmc +1 more source
Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Miya Nakashima +13 more
wiley +1 more source

