Results 101 to 110 of about 7,097 (193)

OMIP‐119: A 36‐Color Full‐Spectrum Flow Cytometry Panel for Deep Immunophenotyping of Peripheral Blood and Ex Vivo Expanded Human T Cells

Cytometry Part A, Volume 107, Issue 12, Page 787-792, December 2025.
ABSTRACT The increasing uptake of adoptive CAR‐T and TCR‐T cell therapies into clinical practice has intensified the need for robust and detailed immunophenotyping of ex vivo expanded T cells. We have developed and optimized an extended 36‐color full‐spectrum flow cytometry panel suitable for in‐depth immunophenotyping of both peripheral blood and ex ...
Robert J. Harris, Benjamin Arkle, Elizabeth Evans, Charles H. V. Smith, Rebecca Teevan, Natalie Bath   +5 more
wiley   +1 more source

Differential expression of CD226 in amyotrophic lateral sclerosis.

, 2022
Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression ...
openaire   +1 more source

Differences in the Effects of Saturated and Trans Fatty Acids on Metabolism and Anxiety‐Like Behavior in Mice

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
Saturated fatty acids (SFA) primarily caused greater physical obesity, whereas Trans‐fatty (TFA) led to more pronounced metabolic damage. Both SFA and TFA diets induced obesity and anxiety‐like behaviors. 7‐Nitroindole (7‐NI) improved anxiety‐like behaviors in SFA‐fed mice but not in TFA‐fed.
Jin‐Cui Yang, Shuang Su, Ping Wang, Heng Zhang, Fan‐Zhi Kong   +4 more
wiley   +1 more source

Gene Expression of CD226 and Its Serum Levels in Patients With Multiple Sclerosis

Caspian Journal of Neurological Sciences, 2018
Background: Recent studies have found some genetic variants as a risk factor for autoimmune diseases such as Multiple Sclerosis (MS). Cluster of Differentiation 226 (CD226) is one of the risk factors for MS.
Fereshteh Alsahebfosoul, Shokofeh Rahimpourkoldeh, Nahid Eskandari, Vahid Shaygannejad, Mazdak Ganjalikhani Hakemi, Arezo Dabiri, Morteza Jafarnia, Omid Mirmossayeb   +7 more
doaj  

Musculoskeletal Diseases: Mechanisms and Therapeutic Advances

MedComm, Volume 6, Issue 12, December 2025.
Musculoskeletal diseases comprise a broad spectrum of inflammatory, degenerative, and neoplastic disorders. Increasing evidence highlights the central role of immune regulation in their pathogenesis, with complex interactions among immune, bone, muscle, and stromal cells.
Xiao Ma, Eloy Yinwang, Xupeng Chai, Fangqian Wang, Zehao Chen, Shengdong Wang, Hao Zhou, Yucheng Xue, Jiangchu Lei, Fanglu Chen, Hengyuan Li, Shixin Chen, Shenzhi Zhao, Kelei Wang, Liang Chen, Junjie Gao, Zhaoming Ye, Nong Lin   +17 more
wiley   +1 more source

A Potential Approach of Mesenchymal Stem Cells Combined Silybin for Synergistic Treatment in Rheumatoid Arthritis via ICOS/ICOSL

MedComm, Volume 6, Issue 11, November 2025.
In our study, UC‐MSCs showed a poor immunoregulatory effect for RA patients with upregulated inducible costimulator (ICOS) in PBMCs. And we identified the ICOS ligand (ICOSL) of UC‐MSCs combined with ICOS of RA patients, activating Phosphatidylinositol 3‐kinase / Protein kinase B / Mammalian target of rapamycin (PI3K/AKT/mTOR).
Yu Chun Wang, Shuai Ding, Ya Feng Wang, Han Xie, Shan Shan Liu, Hong Wei Chen, Dan Wu, Ying Xie, Xin Wen, Yi Zhun Zhu, Ling Yun Sun   +10 more
wiley   +1 more source

Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births. [PDF]

, 2019
Preterm birth (PTB) is leading contributor to infant death in the United States and globally, yet the underlying mechanistic causes are not well understood.
Ackerman, William E, Brockway, Heather M, Buhimschi, Catalin S, Buhimschi, Irina A, Jones, Helen N, Kallapur, Suhas G, Muglia, Louis J   +6 more
core   +3 more sources

Bioengineered Extracellular Vesicles in Emerging Cancer Vaccine Platforms

Small Science, Volume 5, Issue 11, November 2025.
This review highlights recent advances in engineering extracellular vesicles (EVs) as next‐generation cancer vaccines. It outlines their biological roles and antigen‐presenting capacity, explores key strategies for antigen loading and delivery optimization, and summarizes preclinical and clinical applications using EVs from diverse immune and tumor ...
Wonkyung Ahn, Yeram Lee, Gi‐Hoon Nam, Jae Bem You, Eun Jung Lee   +4 more
wiley   +1 more source

Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2. [PDF]

, 2017
Human in vitro generated monocyte-derived dendritic cells (moDCs) and macrophages are used clinically, e.g., to induce immunity against cancer. However, their physiological counterparts, ontogeny, transcriptional regulation, and heterogeneity remains ...
Aschenbrenner, Anna C, Baßler, Kevin, Beyer, Marc, Burgdorf, Sven, Cirovic, Branko, Falk, Christine S, Ginhoux, Florent, Günther, Patrick, Hardt, Anna-Lena, Herresthal, Stefanie, Händler, Kristian, Katzmarski, Natalie, Klee, Kathrin, Kolanus, Waldemar, Kraut, Michael, Krebs, Wolfgang, Kreer, Christoph, Latz, Eicke, Lauterbach, Mario AR, Martin, Bianca, McGovern, Naomi, Melosh, Nicholas A, Newell, Evan W, Papantonopoulou, Olympia, Quast, Thomas, Sander, Jil, Schlitzer, Andreas, Schmidleithner, Lisa M, Schmidt, Susanne V, Schulte-Schrepping, Jonas, Schultze, Joachim L, Sumatoh, Hermi Rizal Bin, Theis, Heidi, Thi Huong, Lan Do, Ulas, Thomas, Wiegmann, Bettina, Xu, Alexander M, Xue, Jia   +37 more
core   +1 more source

Association of Severe Influenza Virus Infections With CD226 (DNAM-1) Variants

The Journal of Infectious Diseases, 2019
AbstractNatural killer (NK)-cell response against influenza viruses partly depends on expression of CD112, a ligand for NK-cell receptor CD226 (DNAM-1). We analyzed whether particular CD226 variants were associated with influenza disease severity. Comparison between 145 patients hospitalized with severe influenza at intensive care units (ICU) with 139 ...
Monika, Redlberger-Fritz, Hannes, Vietzen, Elisabeth, Puchhammer-Stöckl   +2 more
openaire   +2 more sources