Results 1 to 10 of about 26,086 (200)

Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies

Journal for ImmunoTherapy of Cancer, 2023
Background Inhibitory receptor T-cell Immunoreceptor with Ig and ITIM domains (TIGIT) expressed by Natural Killer (NK) and T cells regulates cancer immunity and has been touted as the next frontier in the development of cancer immunotherapeutics ...
Dean A Lee, Jeremiah L Oyer, Md Faqrul Hasan, Tayler J Croom-Perez, Liza D Robles-Carrillo, Sanjana Kumar, Brendan W Andersen, Brian P Tullius, Alicja J Copik, Amanda R Campbell, Thomas A Dieffenthaller, Catherine A Cash, Jonathan E Eloriaga, Meisam Naeimi Kararoudi   +13 more
doaj   +2 more sources

TIGIT enhances CD4+ regulatory T-cell response and mediates immune suppression in a murine ovarian cancer model

Cancer Medicine, 2020
Ovarian cancer (OC) is the fifth‐leading cause of cancer‐related death in women with a pathogenesis involving activation of regulatory T cells (Tregs).
Fengzhen Chen, Yulong Chen
exaly   +2 more sources

The tumor-microenvironment-associated prognostic gene TIGIT promotes malignant phenotypes in esophageal carcinoma [PDF]

Translational Oncology
Background: Previous studies have shown that tumor immune microenvironment related markers are associated with tumor prognosis. However, few studies have explored the prognostic value of tumor cell surface biomarkers (e.g., CD8, TIM3, PD-L1, LAG3, CD163,
Wenjing Wang, Lisha Ye, Jiamin Sheng, Linchun Wen, Huihui Li, Wei Hong, Yongling Ji, Xiaoling Xu   +7 more
doaj   +2 more sources

Expression of TIGIT in splenic and circulatory T cells from mice acutely infected with Toxoplasma gondii

Parasite, 2021
The surface protein TIGIT (T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain) has been characterized as an important regulator of cell-mediated immune responses in various infections.
Wang Shuai, Li Haoran, Zhang Fuqiang, Jiao Yuankai, Xie Qing, Zhang Zhenchao, Li Xiangrui   +6 more
doaj   +1 more source

TIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patients

OncoImmunology, 2021
Accumulating evidence indicates that immune checkpoint inhibitors (ICIs) can restore CD8+ cytotoxic T lymphocyte (CTL) functions in preclinical models of acute myeloid leukemia (AML).
Jana Rakova, Iva Truxova, Peter Holicek, Cyril Salek, Michal Hensler, Lenka Kasikova, Josef Pasulka, Monika Holubova, Marek Kovar, Daniel Lysak, Justin P. Kline, Zdenek Racil, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova   +14 more
doaj   +1 more source

Generating Anti-TIGIT and CD155 Monoclonal Antibodies for Tumor Immunotherapy

Pharmaceutical Fronts, 2022
Many studies have confirmed that the human poliovirus receptor (PVR; CD155) is related to tumor cell migration, invasion, and thus tumor progression. A PVR receptor binds its ligand T cell Ig and the ITIM domain (TIGIT) to inhibit the function of T and ...
Yu-Hang Duan, Yan-lin Bian, Jian-Wei Zhu
doaj   +1 more source

TIGIT+ TIM-3+ NK cells are correlated with NK cell exhaustion and disease progression in patients with hepatitis B virus‑related hepatocellular carcinoma

OncoImmunology, 2021
The prognosis of hepatocellular carcinoma (HCC) is extremely poor, of which hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) accounts for the majority in China.
Lihua Yu, Xiaoli Liu, Xinhui Wang, Fengna Yan, Peng Wang, Yuyong Jiang, Juan Du, Zhiyun Yang   +7 more
doaj   +1 more source

Increased frequency of TIGIT+CD73-CD8+ T cells with a TOX+ TCF-1low profile in patients with newly diagnosed and relapsed AML

OncoImmunology, 2021
The inhibitory receptor TIGIT, as well as theectonucleotidases CD39 and CD73 constitute potential exhaustion markers for T cells. Detailed analysis of these markers can shed light into dysregulation of the T-cell response in acute myeloid leukemia (AML ...
F. Brauneck, F Haag, R. Woost, N. Wildner, E. Tolosa, A. Rissiek, G. Vohwinkel, J. Wellbrock, C. Bokemeyer, J. Schulze zur Wiesch, C. Ackermann, W. Fiedler   +11 more
doaj   +1 more source

Research Progress of Immune Checkpoint TIGIT in Lung Cancer Immunotherapy

Chinese Journal of Lung Cancer, 2022
T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain (TIGIT) is a newly discovered immune checkpoint molecule, mainly expressed on the surface of T cells and natural killer (NK) cells.
Jieqiong WU, Dunqiang REN, Huanhuan BI, Bingqian YI, Hongmei WANG   +4 more
doaj   +1 more source

TIGIT immunosuppressive role in female reproductive system malignant neoplasms: from mechanism to therapy

Акушерство, гинекология и репродукция, 2020
Introduction. Malignant neoplasms of the female reproductive system (ovarian, endometrial, and cervical cancers) account for a significant proportion of female oncology morbidity and mortality. Standard treatment methods, including surgery, chemotherapy,
A. U. Khamadyanova, A. I. Romanova, A. N. Sklyar, A. P. Yamilova, M. G. Miranda Planas, G. D. Galeeva, S. R. Khakimov, A. A. Yakubov, S. K. Bikinyaev, Sh. M. Mammaev, A. A. Vardanyan, P. A. Kantaeva, T. R. Algirieva   +12 more
doaj   +1 more source