Results 21 to 30 of about 26,086 (200)

TIGIT in Lung Cancer: Potential Theranostic Implications [PDF]

, 2023
TIGIT (T cell immunoreceptor with Ig and ITIM domains) is a co-inhibitory receptor expressed on various immune cells, including T cells, NK cells, and dendritic cells.
Edoardo Olmeda, Carlo Pescia, Giuditta Pini, Stefano Ferrero, Gianluca Lopez   +4 more
core   +1 more source

Peripheral TIGIT+ T Follicular Helper Cells That Produce High Levels of Interleukin-21 via OX40 Represent Disease Activity in IgG4-Related Disease

Frontiers in Immunology, 2021
ObjectivesMultiple studies suggest that interleukin (IL)-21 plays a pivotal role in the differentiation of B cells and activation of cytotoxic T cells and is involved in the pathogenesis of IgG4-related disease (IgG4-RD).
Mitsuhiro Akiyama, Katsuya Suzuki, Keiko Yoshimoto, Hidekata Yasuoka, Yuko Kaneko, Tsutomu Takeuchi   +5 more
doaj   +1 more source

Expansion of circulating peripheral TIGIT+CD226+ CD4 T cells with enhanced effector functions in dermatomyositis

Arthritis Research & Therapy, 2021
Background T cell Ig and ITIM domain (TIGIT)/CD226 pathway has a critical role in regulating T cell responses and has come to the forefront in cancer as a promising immunotherapeutic target.
Wenli Li, Chuiwen Deng, Hanbo Yang, Xin Lu, Shanshan Li, Xia Liu, Fang Chen, Lida Chen, Xiaoming Shu, Lu Zhang, Qingyan Liu, Guochun Wang, Qinglin Peng   +12 more
doaj   +1 more source

Overall survival curve for CD155 and TIGIT.

, 2022
Overall survival curve for CD155 and TIGIT.
Hiromitsu Iwamoto (12289515), Fumiyoshi Kojima (2575441), Hiroki Yamaue (277099), Ibu Matsuzaki (2575435), Kenji Matsuda (1277604), Yuichi Takahashi (3015525), Yasuyuki Mitani (4373491), Shin-ichi Murata (25100), Daisuke Murakami (6106532), Yuki Nakamura (138324), Yuki Mizumoto (10918160), Ryuta Iwamoto (11832439)   +11 more
core   +1 more source

TIGIT/CD47 dual high expression predicts prognosis and is associated with immunotherapy response in lung squamous cell carcinoma

Thoracic Cancer, 2022
Background Recent studies indicated that T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) and cluster of differentiation 47 (CD47) have emerged as new potential immunotherapy targets.
Yue Peng, Bin Qiu, Fengwei Tan, Jiachen Xu, Fenglong Bie, Huayu He, Lei Liu, He Tian, Guangyu Bai, Bolun Zhou, Yuan Li, Qilin Huai, Zhenlin Yang, Shugeng Gao   +13 more
doaj   +1 more source

Dynamic Expressions of TIGIT on Splenic T Cells and TIGIT-Mediated Splenic T Cell Dysfunction of Mice With Chronic Toxoplasma gondii Infection

Frontiers in Microbiology, 2021
As an immunosuppressive receptor, T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) play a critical part in cellular immune regulation mediated by pathogen infection.
Haoran Li, Jing Zhang, Changwei Su, Xiaowei Tian, Xuefang Mei, Zhenchao Zhang, Mingyong Wang, Xiangrui Li, Xiangrui Li, Shuai Wang   +9 more
doaj   +1 more source

TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia

OncoImmunology, 2018
While research on T cell exhaustion in context of cancer particularly focuses on CD8+ cytotoxic T cells, the role of inhibitory receptors on CD4+ T-helper cells have remained largely unexplored.
Kemal Catakovic, Franz Josef Gassner, Christoph Ratswohl, Nadja Zaborsky, Stefan Rebhandl, Maria Schubert, Markus Steiner, Julia Christine Gutjahr, Lisa Pleyer, Alexander Egle, Tanja Nicole Hartmann, Richard Greil, Roland Geisberger   +12 more
doaj   +1 more source

Blockade of TIGIT-PVR Axis can Treat Breast Cancer [PDF]

, 2022
This review covers the identification and application of anti-TIGIT antibodies as checkpoint inhibitors for the treatment of triple-negative breast cancers.
Hernandez Garcia, Ana
core   +1 more source

TIGIT in cancer immunotherapy

, 2020
Tumors evade immune-mediated recognition through multiple mechanisms of immune escape. On chronic tumor antigen exposure, T cells become dysfunctional/exhausted and upregulate various checkpoint inhibitory receptors (IRs) that limit T cells’ survival and
Joe-Marc Chauvin, Hassane M Zarour
core   +1 more source

Development and evaluation of nanobody tracers for noninvasive nuclear imaging of the immune-checkpoint TIGIT

, 2023
IntroductionT cell Ig and ITIM domain receptor (TIGIT) is a next-generation immune checkpoint predominantly expressed on activated T cells and NK cells, exhibiting an unfavorable prognostic association with various malignancies.
Wout de Mey, Karine Breckpot, Geert Raes, Nick Devoogdt, Hannelore Ceuppens, Thomas Ertveldt, Fien Meeus, Timo W.M. De Groof, Katty Zeven, Robin Maximilian Awad   +9 more
core   +1 more source