Results 1 to 10 of about 88,713,293 (287)

The Role of TIM-3 in Glioblastoma Progression [PDF]

Cells
Several immunoregulatory or immune checkpoint receptors including T cell immunoglobulin and mucin domain 3 (TIM-3) have been implicated in glioblastoma progression.
Farah Ahmady, Amit Sharma, Adrian A. Achuthan, George Kannourakis, Rodney B. Luwor   +4 more
doaj   +4 more sources

Blockade of Tim-3 Binding to Phosphatidylserine and CEACAM1 Is a Shared Feature of Anti-Tim-3 Antibodies That Have Functional Efficacy

OncoImmunology, 2018
Both in vivo data in preclinical cancer models and in vitro data with T cells from patients with advanced cancer support a role for Tim-3 blockade in promoting effective anti-tumor immunity.
James Nevin, Xiaomo Jiang, Max Klapholz
exaly   +2 more sources

Radiation-induced MYB reduction unleashes TIM-3 expression in NK cells to attenuate antitumor immunity in colorectal cancer [PDF]

Journal of Translational Medicine
Background Colorectal cancer (CRC), the third most common cancer globally, presents challenges like metastasis, recurrence, and therapy resistance.
Gan Tao, Xiuli Guo, Jiaqiang Xiong, Sisi Yan, Xiaowan Guo, Kehua Hu, Wanyi Tai, Lin-lin Bu, Hui Qiu, Qiuji Wu   +9 more
doaj   +2 more sources

TGF-β regulated Tim-3 sustains macrophage phagocytic function and confers protection in Plasmodium yoelii NSM-infected mice [PDF]

Parasites & Vectors
Background T-cell immunoglobulin and mucin domain 3 (Tim-3) is a critical immune checkpoint, yet its role in regulating macrophage function during malaria infection remains poorly understood.
Xiongyu Xie, Guikuan Liang, Mingjie Chen, Lixin Luo, Haiwen Yuan, Shenao Chen, Keyu Lu, Wenbo Peng, Long Xu, Hongyan Xie, Lu Li, Shan Zhao, Haixia Wei, Xingfei Pan, Jun Huang   +14 more
doaj   +2 more sources

Power Imbalance in Collaboration Relationships [PDF]

International Journal of Supply and Operations Management, 2016
Power plays a significant role in many organizational theories such as resource dependency theory and transaction cost economics. It allows the strong companies to win more than others, or more broadly, to coerce others to do what they would not ...
Driss Essabbar, Maria Zrikem, Marc Zolgadri   +2 more
doaj   +3 more sources

TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression. [PDF]

PLoS ONE, 2012
T cell immunoglobulin-3 (TIM-3) has been established as a negative regulatory molecule and plays a critical role in immune tolerance. TIM-3 is upregulated in exhausted CD8(+) T cells in both chronic infection and tumor. However, the nature of TIM-3(+)CD4(
Xin Gao, Yibei Zhu, Gang Li, Haitao Huang, Guangbo Zhang, Fengming Wang, Jing Sun, Qianting Yang, Xueguang Zhang, Binfeng Lu   +9 more
doaj   +1 more source

Tim-3 Is Upregulated in NK Cells during Early Pregnancy and Inhibits NK Cytotoxicity toward Trophoblast in Galectin-9 Dependent Pathway. [PDF]

PLoS ONE, 2016
NK cells accumulate at the maternal-fetal interface (MFI) and play essential roles in maintaining immune tolerance during pregnancy. The mechanisms that facilitate NK cells tolerance to fetal tissue are largely unknown.
Jintang Sun, Meixiang Yang, Yanli Ban, Wenjuan Gao, Bingfeng Song, Yang Wang, Yun Zhang, Qianqian Shao, Beihua Kong, Xun Qu   +9 more
doaj   +1 more source

Expression of inhibitory receptors PD-1, CTLA-4, and Tim-3 by peripheral T cells during pregnancy

Бюллетень сибирской медицины, 2022
Background. Inhibitory receptors and their ligands (also called checkpoint molecules) are important feedback regulators of the immune response. However, their role in immunological adaptation during pregnancy remains poorly understood.The aim of the ...
E. A. Smetanenko, N. A. Khonina, O. Yu. Leplina, M. A. Tikhonova, E. V. Batorov, N. M. Pasman, E. R. Chernykh   +6 more
doaj   +1 more source

Tim-3-expressing CD4+ and CD8+ T cells in human tuberculosis (TB) exhibit polarized effector memory phenotypes and stronger anti-TB effector functions.

PLoS Pathogens, 2012
T-cell immune responses modulated by T-cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) during Mycobacterium tuberculosis (Mtb) infection in humans remain poorly understood.
Yueqin Qiu, Jianbo Chen, Hongying Liao, Yan Zhang, Hua Wang, Shaoyuan Li, Yanfen Luo, Danyun Fang, Guobao Li, Boping Zhou, Ling Shen, Crystal Y Chen, Dan Huang, Jiye Cai, Kaiyuan Cao, Lifang Jiang, Gucheng Zeng, Zheng W Chen   +17 more
doaj   +1 more source

Tim-3+ decidual Mφs induced Th2 and Treg bias in decidual CD4+T cells and promoted pregnancy maintenance via CD132

Cell Death and Disease, 2022
T-cell immunoglobulin mucin-3 (Tim-3) plays roles in the functional regulation of both adaptive and innate immune cells and is greatly involved in many diseases. However, the precise roles of Tim-3 on macrophages (Mφs) in pregnancy remain unstated.
Mengdie Li, Fengrun Sun, Yuanyuan Xu, Lanting Chen, Chunqin Chen, Liyuan Cui, Jinfeng Qian, Dajin Li, Songcun Wang, Meirong Du   +9 more
doaj   +1 more source