Results 31 to 40 of about 139,675 (244)

TIM-3 does not act as a receptor for galectin-9. [PDF]

PLoS Pathogens, 2013
T cell immunoglobulin and mucin protein 3 (TIM-3) is a type I cell surface protein that was originally identified as a marker for murine T helper type 1 cells. TIM-3 was found to negatively regulate murine T cell responses and galectin-9 was described as
Judith Leitner, Armin Rieger, Winfried F Pickl, Gerhard Zlabinger, Katharina Grabmeier-Pfistershammer, Peter Steinberger   +5 more
doaj   +1 more source

Increased co-expression of TIM-3 with TIGIT or 2B4 on CD8+ T cells is associated with poor prognosis in locally advanced nasopharyngeal carcinoma

Biomolecules & Biomedicine, 2023
The use of immune checkpoint inhibitors in malignant tumors improves patient outcomes. Because single-agent immune checkpoint blockade has a low objective response rate, it is meaningful to explore combined blockade of immune checkpoint receptors.
Xiaolin Xie, Yaning Feng, Peiwen Fan, Danning Dong, Xuan Yao, Yanchun Peng, Ruozheng Wang   +6 more
doaj   +1 more source

Genetic Mutations of Tim-3 Ligand and Exhausted Tim-3+ CD8+ T Cells and Survival in Diffuse Large B Cell Lymphoma

Journal of Immunology Research, 2020
Tim-3 is a promising target for antitumor immunotherapy. A number of clinical trials are evaluating the efficacy of anti-Tim-3 therapies as a single agent or combinations in solid tumors and haematologic malignancies.
Tingting Zhang, Tianyuan Ren, Zheng Song, Jing Zhao, Lei Jiao, Zhenzhen Zhang, Jin He, Xianming Liu, Lihua Qiu, Lanfang Li, Shiyong Zhou, Bin Meng, Qiongli Zhai, Xiubao Ren, Zhengzi Qian, Xianhuo Wang, Huilai Zhang   +16 more
doaj   +1 more source

Immunoregulation effects of TIM-3 on tumors

Neoplasma, 2019
Cancer poses a serious threat to human health and its increasing incidence has made it one of the most common causes of death. Immune factors affect in vivo tumor cell survival and expansion, and cancer patients have obvious cell immune dysfunction and low anti-tumor immunity.
C C, Sheng, F Y, Han
openaire   +3 more sources

TIM-3 Regulates Distinct Functions in Macrophages [PDF]

Frontiers in Immunology, 2016
The transmembrane protein TIM-3 is a type I protein expressed by sub-types of lymphoid cells, such as lymphocytes Th1, Th17, Tc1, NK, as well as in myeloid cells. Scientific evidence indicates that this molecule acts as a negative regulator of T lymphocyte activation and that its expression is modified in viral infections or autoimmune diseases.
Ocaña-Guzman, Ranferi, Torre-Bouscoulet, Luis, Sada-Ovalle, Isabel   +2 more
openaire   +2 more sources

TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway. [PDF]

PLoS ONE, 2015
TIM-3 (T cell immunoglobulin and mucin-domain containing protein 3) is a member of the TIM family of proteins that is preferentially expressed on Th1 polarized CD4+ and CD8+ T cells.
Brian Tomkowicz, Eileen Walsh, Adam Cotty, Raluca Verona, Nina Sabins, Fred Kaplan, Sandy Santulli-Marotto, Chen-Ni Chin, Jill Mooney, Russell B Lingham, Michael Naso, Timothy McCabe   +11 more
doaj   +1 more source

The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis [PDF]

Iranian Journal of Immunology, 2020
Background: Tim-3 has been considered as an ideal target for the immunotherapy of inflammation, but it is unclear whether Tim-3 also plays an important role in acute pancreatitis (AP), as well.
Min Lin, Jin Huang, Wei-Chang Chen, Zhi-Ning Fan, Xihu Qin   +4 more
doaj   +1 more source

Editorial: Tim-3 puts on the brakes [PDF]

Journal of Leukocyte Biology, 2012
Discussion on how Tim-3 negatively regulates both innate and adaptive immune responses.
openaire   +2 more sources

Tim-3 expression in cervical cancer promotes tumor metastasis.

PLoS ONE, 2013
BackgroundT cell immunoglobulin mucin-3 (Tim-3) has been identified as a negative regulator of anti-tumor immunity. Recent studies highlight the important role of Tim-3 in the CD8(+) T cell exhaustion that takes place in both human and animal cancer ...
Yang Cao, Xiaoxi Zhou, Xiaoyuan Huang, Qinlu Li, Lili Gao, Lijun Jiang, Mei Huang, Jianfeng Zhou   +7 more
doaj   +1 more source

Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α pathway

Molecular Metabolism, 2019
Objective: Macrophage-mediated inflammation plays a significant role in the development and progression of diabetic nephropathy (DN). However, the underlying mechanisms remain unclear. Studies suggest that T cell immunoglobulin domain and mucin domain-3 (
Huimin Yang, Tingting Xie, Dengren Li, Xianhong Du, Tixiao Wang, Chunyang Li, Xiaojia Song, Leiqi Xu, Fan Yi, Xiaohong Liang, Lifen Gao, Xiangdong Yang, Chunhong Ma   +12 more
doaj   +1 more source