Results 31 to 40 of about 18,801,342 (289)
TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway. [PDF]
PLoS ONE, 2015 TIM-3 (T cell immunoglobulin and mucin-domain containing protein 3) is a member of the TIM family of proteins that is preferentially expressed on Th1 polarized CD4+ and CD8+ T cells.
Brian Tomkowicz +11 more
doaj +1 more source
, 2017 Co-inhibitory receptors play a key role in regulating T cell responses and maintaining immune homeostasis. Their inhibitory function prevents autoimmune responses but also restricts the ability of T cells to mount effective immune responses against tumors or persistent pathogens.
Joller, Nicole, Kuchroo, Vijay K.
openaire +4 more sources
Analysis of Tim-3 as a therapeutic target in prostate cancer
Tumor Biology, 2017 Tim-3 (T-cell immunoglobulin domain and mucin domain–containing molecule 3) is a newly discovered immunomodulatory protein, which plays an important role in immunity regulation. Recent evidence suggests that Tim-3 is differentially regulated in a variety
Yongrui Piao, Xuanshun Jin
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Tim-3 expression defines regulatory T cells in human tumors. [PDF]
PLoS ONE, 2013 Tim-3, a member of the novel Tim (T cell immunoglobulin and mucin domain) family, has been reported to negatively regulate the immune responses against viral infection and had implications for autoimmune disease.
Jing Yan +5 more
doaj +1 more source
IMMUNOLOGICAL ASPECTS OF CROHN’S DISEASE: A REGULATORY FUNCTION OF TIM-3/ GALECTIN-9 IN LYTH1
Euromediterranean Biomedical Journal, 2017 Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) and its etiology is multifactorial and involves a combination of genetic and environmental factors.
Francesco Carini
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Медицинская иммунология, 2021 During the course of chronic viral infections or tumor growth, due to the constant presence of antigen and inflammation, a dysfunctional state of T-cells called exhaustion occurs.
Yu. A. Shevchenko +6 more
doaj +1 more source
TIM‐3: An emerging target in the liver diseases [PDF]
Scandinavian Journal of Immunology, 2020 AbstractT cell immunoglobulin domain and mucin domain‐containing molecule 3 (TIM‐3) is found expression in the surface of terminally differentiated T cells and belongs to the TIM family of type Ⅰ transmembrane proteins. It binds to the ligand Galectin‐9 and mediates T cell apoptosis.
Lizhen Zhao +4 more
openaire +2 more sources
Immunoregulation effects of TIM-3 on tumors
Neoplasma, 2019 Cancer poses a serious threat to human health and its increasing incidence has made it one of the most common causes of death. Immune factors affect in vivo tumor cell survival and expansion, and cancer patients have obvious cell immune dysfunction and low anti-tumor immunity.
C C, Sheng, F Y, Han
openaire +3 more sources
Computers and Education OpenAs digital technologies and Artificial Intelligence (AI) continue to reshape educational environments, understanding the motivations of student teachers is critical to developing effective teacher education programmes.
Judit Martínez-Moreno +3 more
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The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis [PDF]
Iranian Journal of Immunology, 2020 Background: Tim-3 has been considered as an ideal target for the immunotherapy of inflammation, but it is unclear whether Tim-3 also plays an important role in acute pancreatitis (AP), as well.
Min Lin +4 more
doaj +1 more source