Results 51 to 60 of about 88,713,293 (287)

Humans of AI3SD: Professor Tim Albrecht

, 2020
This interview forms part of our Humans of AI3SD Series. Professor Tim Albrecht, a Professor of Physical Chemistry at the University of Birmingham was interviewed by Michelle Pauli at our AI3SD Network+ Conference in 2019.
Pauli, Michelle, Albrecht, Tim
core   +1 more source

The immune checkpoint LAG-3 is expressed by melanoma cells and correlates with clinical progression of the melanoma

OncoImmunology
Immune checkpoint blockers have substantially improved prognosis of melanoma patients, nevertheless, resistance remains a significant problem. Here, intrinsic and extrinsic factors in the tumor microenvironment are discussed, including the expression of ...
Melanie Wiecken, Devayani Machiraju, Shounak Chakraborty, Eva-Maria Mayr, Bénédicte Lenoir, Rosa Eurich, Jasmin Richter, Nicole Pfarr, Niels Halama, Jessica C. Hassel   +9 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

TIM-3 Rs10515746 (A/C) and Rs10053538 (C/A) Gene Polymorphisms and Risk of Multiple Sclerosis

Iranian Journal of Public Health, 2016
Background: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) caused by autoreactive T cells against myelin antigens.
Esmat YAGHOOBI, Saeed ABEDIAN, Omid BABANI, Maryam IZAD   +3 more
doaj  

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

TIM-3 expression on lymphocytes from Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas

, 2017
Gating strategy to assess for surface expression of TIM-3 on (A) CD4+ and (B) CD8+ T cells isolated from peripheral lymph nodes, lungs, livers, spleens, and brains.
Alessandro Olivi (471259), Eileen S. Kim (14997527), Haiying Xu (258277), Phuoc T. Tran (14899412), Sarah Harris-Bookman (14997530), Christopher M. Jackson (14995439), Tomas Garzon-Muvdi (168470), Mira A. Patel (1774930), Xiaobu Ye (596796), Debebe Theodros (14935094), Ann Liu (1353414), Michael Lim (596800), Eric W. Sankey (10143086), Drew M. Pardoll (8689350), Allison M. Martin (14997536), Betty M. Tyler (14997539), Henry Brem (596798), Janis M. Taube (6178604), Peter C. Burger (14997542), Mary Sheu (14997533), Esteban Velarde (418965), Antonella Mangraviti (1353426), Ada Tam (6323708), Dimitrios Mathios (596791), Jennifer E. Kim (14997524), Charles G. Drake (7549529)   +25 more
core   +1 more source

The Role of Tim-3 on dNK Cells Dysfunction During Abnormal Pregnancy With Toxoplasma gondii Infection

Frontiers in Cellular and Infection Microbiology, 2021
Vertical transmission of Toxoplasma gondii (T. gondii) infection during gestation can result in severe complications such as abortion, congenital malformation, fetal teratogenesis, etc.
Teng Li, Lijun Cui, Xiaoyan Xu, Haixia Zhang, Yuzhu Jiang, Liqin Ren, Chunyan Yang, Xianbing Liu, Xuemei Hu   +8 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Increased bovine Tim-3 and its ligand expressions during bovine leukemia virus infection

Veterinary Research, 2012
The immunoinhibitory receptor T cell immunoglobulin domain and mucin domain-3 (Tim-3) and its ligand, galectin-9 (Gal-9), are involved in the immune evasion mechanisms for several pathogens causing chronic infections.
Okagawa Tomohiro, Konnai Satoru, Ikebuchi Ryoyo, Suzuki Saori, Shirai Tatsuya, Sunden Yuji, Onuma Misao, Murata Shiro, Ohashi Kazuhiko   +8 more
doaj   +1 more source