Results 11 to 20 of about 88,713,293 (287)
Oncogene-induced TIM-3 ligand expression dictates susceptibility to anti–TIM-3 therapy in mice [PDF]
The Journal of Clinical InvestigationLeukemia relapse is a major cause of death after allogeneic hematopoietic cell transplantation (allo-HCT). We tested the potential of targeting T cell (Tc) immunoglobulin and mucin-containing molecule 3 (TIM-3) for improving graft-versus-leukemia (GVL ...
Nana Talvard-Balland +41 more
doaj +9 more sources
médecine/sciences, 2018 Les lymphocytes T (LT) exprimant de multiples molécules de co-stimulation inhibitrices (PD-1, Tim-3, Lag-3, etc.) perdent leur activité anti-tumorale. PD-1 est une cible thérapeutique majeure dans le traitement du cancer, mais son expression isolée ne ...
Marc-Olivier Timsit +12 more
core +3 more sources
Importance of photophosphatidylserine and Tim-3 in photoimmunotherapy
RSC Medicinal Chemistry, 2022 Natural killer (NK) cells help regulate autoimmune reactions, but overactivation causes harm. A Tim-3 receptor is an immune checkpoint that prevents overactivation.
Kumar, Arun +3 more
core +3 more sources
TIM-3 expression in breast cancer [PDF]
OncoImmunology, 2018 Tumor-infiltrating lymphocytes (TILs) are predominantly present in breast cancer patients with estrogen receptor negative tumors, among whom increasing levels correlate with favorable outcomes.
Samantha Burugu +4 more
doaj +3 more sources
TIM-3 in Cardiovascular Disease. [PDF]
Curr Heart Fail RepAbstract Purpose of review We summarise the current knowledge of T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) across innate and adaptive immune cells and compile emerging evidence in cardiovascular disease (CVD ...
Yousif LI +4 more
europepmc +4 more sources
Immune regulation by Tim-3 [PDF]
F1000Research, 2018 T-cell immunoglobulin and mucin domain 3 (Tim-3) is a transmembrane protein that in both mice and humans has been shown to possess various functions in a context-dependent manner. Thus, Tim-3 has been associated with both inhibitory and co-stimulatory function, depending in part on the specific cell type and immune response course.
Hridesh Banerjee, Lawrence P. Kane
openaire +2 more sources
, 2023 Typeface archive book featuring ten typefaces design by Tim Hutchinson. Each typeface is displayed as a full specimen throughout the book plus some experimental & live application of selected typefaces at the end f the ...
Hutchinson, Tim
core +3 more sources
The role of the TIM-3 receptor in inflammatory bowel disease and autoimmunity: implications for TIM-3 and TCR crosstalk. [PDF]
J Mol Med (Berl)Abstract The T cell immunoglobulin and mucin-domain receptor 3 (TIM-3) is an immune checkpoint receptor with complex effects on T cell activation and tolerance. TIM-3 is expressed on the surface of T cells in close proximity to the T cell receptor (TCR), where it mainly acts co-inhibitory, despite lacking typical inhibitory ...
Gabel M +3 more
europepmc +4 more sources
Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. [PDF]
, 2012 The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation.
Cheng, Y +59 more
core +1 more source
Frontiers in Oncology, 2021 BackgroundAs a novel immune checkpoint molecular, T-cell immunoglobulin mucin 3 (TIM-3) is emerging as a therapeutic target for cancer immunotherapy. However, the predictive role of TIM-3 in cancer remains largely undetermined. This study was designed to
Kui Zang +5 more
doaj +1 more source