Results 11 to 20 of about 139,675 (244)
Analysis of Tim-3 as a therapeutic target in prostate cancer [PDF]
Tumor Biology, 2017 Tim-3 (T-cell immunoglobulin domain and mucin domain–containing molecule 3) is a newly discovered immunomodulatory protein, which plays an important role in immunity regulation. Recent evidence suggests that Tim-3 is differentially regulated in a variety
Yongrui Piao, Xuanshun Jin
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TIM-3 Promotes Proliferation of Acute Myeloid Leukemia Blasts [PDF]
BiomedicinesBackground: The immunocheckpoint TIM-3 is also expressed on acute myeloid leukemia (AML) blasts. Its prognostic significance requires clarification through subgroup analysis, while its functional roles and underlying mechanisms remain to be further ...
Zong-Yan Shi +4 more
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Radiation-induced MYB reduction unleashes TIM-3 expression in NK cells to attenuate antitumor immunity in colorectal cancer [PDF]
Journal of Translational MedicineBackground Colorectal cancer (CRC), the third most common cancer globally, presents challenges like metastasis, recurrence, and therapy resistance.
Gan Tao +9 more
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TGF-β regulated Tim-3 sustains macrophage phagocytic function and confers protection in Plasmodium yoelii NSM-infected mice [PDF]
Parasites & VectorsBackground T-cell immunoglobulin and mucin domain 3 (Tim-3) is a critical immune checkpoint, yet its role in regulating macrophage function during malaria infection remains poorly understood.
Xiongyu Xie +14 more
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Differential impact of TIM-3 ligands on NK cell function [PDF]
Journal for ImmunoTherapy of CancerBackground The transmembrane protein T-cell immunoglobulin and mucin-domain containing molecule 3 (TIM-3) is an immune checkpoint receptor that is expressed by a variety of leukocyte subsets, particularly in the tumor microenvironment. An effective TIM-3-
Xin Zhang +13 more
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médecine/sciences, 2018 Les lymphocytes T (LT) exprimant de multiples molécules de co-stimulation inhibitrices (PD-1, Tim-3, Lag-3, etc.) perdent leur activité anti-tumorale. PD-1 est une cible thérapeutique majeure dans le traitement du cancer, mais son expression isolée ne signe pas une dysfonction.
Kiera Clayton, Mario Ostrowski
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Power Imbalance in Collaboration Relationships [PDF]
International Journal of Supply and Operations Management, 2016 Power plays a significant role in many organizational theories such as resource dependency theory and transaction cost economics. It allows the strong companies to win more than others, or more broadly, to coerce others to do what they would not ...
Driss Essabbar +2 more
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Immune regulation by Tim-3 [PDF]
F1000Research, 2018 T-cell immunoglobulin and mucin domain 3 (Tim-3) is a transmembrane protein that in both mice and humans has been shown to possess various functions in a context-dependent manner. Thus, Tim-3 has been associated with both inhibitory and co-stimulatory function, depending in part on the specific cell type and immune response course.
Hridesh Banerjee, Lawrence P. Kane
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TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression. [PDF]
PLoS ONE, 2012 T cell immunoglobulin-3 (TIM-3) has been established as a negative regulatory molecule and plays a critical role in immune tolerance. TIM-3 is upregulated in exhausted CD8(+) T cells in both chronic infection and tumor. However, the nature of TIM-3(+)CD4(
Xin Gao +9 more
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TIM-3 pathway dysregulation and targeting in cancer [PDF]
Expert Review of Anticancer Therapy, 2021 Dysfunction of the immune system is a hallmark of cancer. Through increased understanding of the complex interactions between immunity and cancer, immunotherapy has emerged as a treatment modality for different types of cancer. Promising activity with immunotherapy has been reported in numerous malignancies, but challenges such as limited response ...
Amer M, Zeidan +2 more
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