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, 2023 Typeface archive book featuring ten typefaces design by Tim Hutchinson. Each typeface is displayed as a full specimen throughout the book plus some experimental & live application of selected typefaces at the end f the ...
Hutchinson, Tim
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Power Imbalance in Collaboration Relationships [PDF]
International Journal of Supply and Operations Management, 2016 Power plays a significant role in many organizational theories such as resource dependency theory and transaction cost economics. It allows the strong companies to win more than others, or more broadly, to coerce others to do what they would not ...
Driss Essabbar +2 more
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Immune regulation by Tim-3 [PDF]
F1000Research, 2018 T-cell immunoglobulin and mucin domain 3 (Tim-3) is a transmembrane protein that in both mice and humans has been shown to possess various functions in a context-dependent manner. Thus, Tim-3 has been associated with both inhibitory and co-stimulatory function, depending in part on the specific cell type and immune response course.
Hridesh Banerjee, Lawrence P. Kane
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TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression. [PDF]
PLoS ONE, 2012 T cell immunoglobulin-3 (TIM-3) has been established as a negative regulatory molecule and plays a critical role in immune tolerance. TIM-3 is upregulated in exhausted CD8(+) T cells in both chronic infection and tumor. However, the nature of TIM-3(+)CD4(
Xin Gao +9 more
doaj +1 more source
Tim-3 Is Upregulated in NK Cells during Early Pregnancy and Inhibits NK Cytotoxicity toward Trophoblast in Galectin-9 Dependent Pathway. [PDF]
PLoS ONE, 2016 NK cells accumulate at the maternal-fetal interface (MFI) and play essential roles in maintaining immune tolerance during pregnancy. The mechanisms that facilitate NK cells tolerance to fetal tissue are largely unknown.
Jintang Sun +9 more
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Expression of inhibitory receptors PD-1, CTLA-4, and Tim-3 by peripheral T cells during pregnancy
Бюллетень сибирской медицины, 2022 Background. Inhibitory receptors and their ligands (also called checkpoint molecules) are important feedback regulators of the immune response. However, their role in immunological adaptation during pregnancy remains poorly understood.The aim of the ...
E. A. Smetanenko +6 more
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Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. [PDF]
, 2012 The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation.
Cheng, Y +59 more
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PLoS Pathogens, 2012 T-cell immune responses modulated by T-cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) during Mycobacterium tuberculosis (Mtb) infection in humans remain poorly understood.
Yueqin Qiu +17 more
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Cell Death and Disease, 2022 T-cell immunoglobulin mucin-3 (Tim-3) plays roles in the functional regulation of both adaptive and innate immune cells and is greatly involved in many diseases. However, the precise roles of Tim-3 on macrophages (Mφs) in pregnancy remain unstated.
Mengdie Li +9 more
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Frontiers in Oncology, 2021 BackgroundAs a novel immune checkpoint molecular, T-cell immunoglobulin mucin 3 (TIM-3) is emerging as a therapeutic target for cancer immunotherapy. However, the predictive role of TIM-3 in cancer remains largely undetermined. This study was designed to
Kui Zang +5 more
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