Results 1 to 10 of about 5,468 (152)

CD226 Deficiency Attenuates Periodontal Bone Destruction in a Murine Ligature-Induced Periodontitis Model [PDF]

Biology
Periodontal disease is widely recognised as a chronic infectious-inflammatory disorder, leading to the destruction of alveolar bone. Osteoclasts and their progenitors have been demonstrated to play pivotal roles in the process of periodontitis-induced ...
Yi Li, Wenjing Zhou, Xutao Chen, Wenli Dan, Lihua Chen, Fang Zhao, Liang Fang   +6 more
doaj   +3 more sources

CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages [PDF]

Cell Reports
Summary: CD8+ T cells defend against Mycobacterium tuberculosis (Mtb) infection but variably recognize Mtb-infected macrophages. To investigate how chronic infection affects the diversity of lung parenchymal CD8+ T cells, we perform single-cell RNA ...
Tomoyo Shinkawa, Evelyn Chang, Tasfia Rakib, Kelly Cavallo, Rocky Lai, Samuel M. Behar   +5 more
doaj   +3 more sources

The Immune Regulatory Functions of CD226 and Its Implications in Immune-Mediated Diseases [PDF]

Biomolecules
CD226, a member of the immunoglobulin superfamily, serves as a critical regulator in various immunological processes. CD226 is expressed across immune and non-immune cells, with predominant expression being observed in natural killer (NK) cells and T ...
Keyan Liu, Yuanzhen Liu, Huabao Xiong, Zhaochen Ning   +3 more
doaj   +3 more sources

Immunotherapeutic strategies targeting the PVR–TIGIT/CD96/CD226 signaling pathway in glioma treatment [PDF]

Annals of Medicine
Background To summarise the molecular interactions of Poliovirus Receptor (PVR) with its receptors (inhibitory TIGIT/CD96 and activating CD226), to delineate how these interactions drive glioma immune escape, and to evaluate emerging PVR-directed ...
Da Qian, Jiazheng Guo, Yuchen Duan, Yibing Zhou, Chaoshen Wu, Qun Chen, Jinquan Cai   +6 more
doaj   +3 more sources

Increased Proportion of CD226+ B Cells Is Associated With the Disease Activity and Prognosis of Systemic Lupus Erythematosus

Frontiers in Immunology, 2021
BackgroundCD226, an activating receptor expressed on the surface of natural killer (NK) cells and T cells, is also seen on B cells and CD226 polymorphism is associated with systemic lupus erythematosus (SLE).
Yasutaka Kimoto, Takahiko Horiuchi, Hiroki Mitoma   +2 more
exaly   +3 more sources

CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions

Cell Reports, 2023
Summary: Regulatory T (Treg) cells exhibit immunosuppressive phenotypes and particular metabolic patterns with certain degrees of plasticity. Previous studies of the effects of the co-stimulatory molecule CD226 on Treg cells are controversial.
Ran Zhuang, Yitian Liu
exaly   +3 more sources

Integrative Omics Analysis Reveals a CD206⁺ Macrophage/Dendritic Cell-CD155-TIGIT⁺ Regulatory T Cell Axis as a Protective Immune Checkpoint Pathway in Atherosclerosis Progression. [PDF]

Barrier Immun
ABSTRACT RNA sequencing (RNA‐seq) analysis revealed transcriptional features indicative of sustained immunosuppression within regulatory T cells (Tregs) isolated from atherosclerotic tissues, highlighting the critical contribution of immune checkpoint (ICP) receptor–ligand interactions to atherosclerosis progression. To comprehensively characterize the
Shao Y, Saaoud F, Issa MB, Xu K, Lu Y, Hung SY, Liu J, Yuan B, Wei J, Wu S, Mohsin S, Zhou Z, Kosmider B, Martinez L, Vazquez-Padron R, Wang H, Yang X.   +16 more
europepmc   +2 more sources

Restoring the CD226 in CD8+T cells overcomes TIGIT-refractory immunity in HER2+ breast cancer [PDF]

Cell Death and Disease
Immune checkpoint blockade (ICB) has shown limited activity in HER2+ breast cancer, yet the mechanisms underlying this refractoriness remain unclear. Integrating single-cell transcriptomics from untreated human and murine HER2+ tumors with an anti-HER2 ...
Liyi Zhang, Jiaoduan Li, Bingqiu Xiu, Chen Zheng, Qi Zhang, Huixin Lu, Zehao Wang, Zhibo Shao, Jingyan Xue, Yayun Chi, Dongxi Xiang, Jiong Wu   +11 more
doaj   +2 more sources

CD226+ B cells in primary Sjögren’s syndrome: a key player in clinical manifestations and disease pathogenesis [PDF]

Frontiers in Immunology
IntroductionPrimary Sjögren’s syndrome (pSS) is a systemic autoimmune disorder characterized by lymphocytic infiltration of exocrine glands, leading to sicca symptoms and systemic complications.
Ping Zhao, Ping Zhao, Saizhe Song, Song Zhang, Cheng Peng, Wei Cheng, Xin Chang, Xin Chang, Changhao Xie, Zhongli Hu, Cuiping Liu   +10 more
doaj   +2 more sources

CD155-TIGIT/CD96/CD226 immune checkpoint axis interacting with tumor-infiltrating lymphocytes to exhibit diverse prognostic effects on breast cancer: a cohort study [PDF]

Frontiers in Immunology
BackgroundCD155, an immune checkpoint molecule interacted with receptors of TIGIT/CD96/CD226 to exhibit co-inhibitory and co-stimulatory modulation on tumor immune microenvironment. Nevertheless, the exploration of collectively prognostic effect of these
Xin Ou, Xin Ou, Junyu Yin, Junyu Yin, Feng Shi, Yanjie Zhao, Quan Zhou, Keyu Yuan, Shuzhen Lyu, Jiangping Wu, Jiangping Wu, Yanping Li, Qingkun Song, Qingkun Song   +13 more
doaj   +2 more sources