Results 11 to 20 of about 5,468 (152)

Increased blood CD226- inflammatory monocytes with low antigen presenting potential correlate positively with severity of hemorrhagic fever with renal syndrome

Annals of Medicine, 2023
Background Hantaan virus (HTNV) infection can cause severe hemorrhagic fever with renal syndrome (HFRS). Inflammatory monocytes (iMOs) are involved in early antiviral responses.
Kang Tang, Yongli Hou, Linfeng Cheng, Yusi Zhang, Juan Li, Qi Qin, Xuyang Zheng, Xiaozhou Jia, Chunmei Zhang, Ran Zhuang, Yun Zhang, Boquan Jin, Lihua Chen, Ying Ma   +13 more
doaj   +2 more sources

Blocking CD226 Promotes Allogeneic Transplant Immune Tolerance and Improves Skin Graft Survival by Increasing the Frequency of Regulatory T Cells in a Murine Model

Cellular Physiology and Biochemistry, 2018
Background/Aims: Regulatory T cells (Tregs) play key roles in maintaining peripheral tolerance and preventing autoimmune disease. Treg modulation could be helpful in treating malignancies, autoimmune disease, and allergies, as well as to facilitate organ
Tian Liu, Dongliang Zhang, Yuan Zhang, Xiangsheng Xu, Bo Zhou, Liang Fang, Yun Zhang, Yingjun Su, Boquan Jin, Ran Zhuang, Shuzhong Guo   +10 more
doaj   +3 more sources

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia [PDF]

Molecular Oncology
CD8+ T cells, a subset of T cells identified by the surface glycoprotein CD8, particularly those expressing the co‐stimulatory molecule CD226, play a crucial role in the immune response to malignancies. However, their role in chronic lymphocytic leukemia
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
doaj   +2 more sources

CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation [PDF]

Frontiers in Immunology, 2020
The costimulatory molecule CD226 is highly expressed on effector/memory T cells and natural killer cells. Costimulatory signals received by T cells can impact both central and peripheral tolerance mechanisms.
Melanie R. Shapiro, Wen-I Yeh, Joshua R. Longfield, John Gallagher, Caridad M. Infante, Sarah Wellford, Amanda L. Posgai, Mark A. Atkinson, Mark A. Atkinson, Martha Campbell-Thompson, Scott M. Lieberman, David V. Serreze, Aron M. Geurts, Yi-Guang Chen, Todd M. Brusko, Todd M. Brusko   +15 more
doaj   +2 more sources

Expression of CD226 is upregulated on Tr1 cells from neuromyelitis optica spectrum disorder patients

Brain and Behavior, 2022
Background Neuromyelitis optica spectrum disorder (NMOSD) is a central and acute demyelinating disease of the central nervous system with unusual clinical course.
Ping Chen, Mingmei Wu, Ning Wang, Feng Xia, Fang Du, Zhirong Liu, Jinchun Wang, Jingyi Jin, Boquan Jin, Gang Zhao, Lihua Chen, Jing Yi, Liang Fang   +12 more
doaj   +2 more sources

Gene Expression of CD226 and Its Serum Levels in Patients With Multiple Sclerosis

Caspian Journal of Neurological Sciences, 2018
Background: Recent studies have found some genetic variants as a risk factor for autoimmune diseases such as Multiple Sclerosis (MS). Cluster of Differentiation 226 (CD226) is one of the risk factors for MS.
Fereshteh Alsahebfosoul, Shokofeh Rahimpourkoldeh, Nahid Eskandari, Vahid Shaygannejad, Mazdak Ganjalikhani Hakemi, Arezo Dabiri, Morteza Jafarnia, Omid Mirmossayeb   +7 more
doaj   +1 more source

CD226 implicated in Akt-dependent apoptosis of CD4+ T cell contributes to asthmatic pathogenesis

Cell Death and Disease
Asthma is a chronic airway inflammatory disease in which CD4+ T cell dysregulation occurs. Here, we investigated the molecular role and clinical significance of CD226, a costimulatory molecule of T lymphocytes, in the development of allergic asthma.
Yuan Zhang, Yang Xie, Xuexin Zhang, Chujun Duan, Jingchang Ma, Yuling Wang, Yilin Wu, Niqi Shan, Kun Cheng, Ran Zhuang, Ka Bian   +10 more
doaj   +2 more sources

Overcoming CD226-related immune evasion in acute myeloid leukemia with CD38 CAR-engineered NK cells

Cell Reports
Summary: CD226 plays a vital role in natural killer (NK) cell cytotoxicity, interacting with its ligands CD112 and CD155 to initiate immune synapse formation, primarily through leukocyte function-associated-1 (LFA-1). Our study examined the role of CD226
Luciana Melo Garcia, Achintyan Gangadharan, Pinaki Banerjee, Ye Li, Andy G.X. Zeng, Hind Rafei, Paul Lin, Bijender Kumar, Sunil Acharya, May Daher, Luis Muniz-Feliciano, Gary M. Deyter, Gabriel Dominguez, Jeong Min Park, Francia Reyes Silva, Ana Karen Nunez Cortes, Rafet Basar, Nadima Uprety, Mayra Shanley, Mecit Kaplan, Enli Liu, Elizabeth J. Shpall, Katayoun Rezvani   +22 more
doaj   +2 more sources

TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation [PDF]

Nature Communications, 2023
TIGIT is an inhibitory receptor expressed on lymphocytes and can inhibit T cells by preventing CD226 co-stimulation through interactions in cis or through competition of shared ligands. Whether TIGIT directly delivers cell-intrinsic inhibitory signals in
Jonathan D. Worboys, Katherine N. Vowell, Roseanna K. Hare, Ashley R. Ambrose, Margherita Bertuzzi, Michael A. Conner, Florence P. Patel, William H. Zammit, Judit Gali-Moya, Khodor S. Hazime, Katherine L. Jones, Camille Rey, Stipan Jonjic, Tihana Lenac Rovis, Gillian M. Tannahill, Gabriela Dos Santos Cruz De Matos, Jeremy D. Waight, Daniel M. Davis   +17 more
doaj   +2 more sources

The CD226/TIGIT axis is involved in T cell hypo-responsiveness appearance in long-term kidney transplant recipients

Scientific Reports, 2022
T cell exhaustion refers to a dysfunctional state in which effector T cells present a decreased ability to proliferate and to produce cytokines, while the co-expression of inhibitory receptors increases.
Arnaud Del Bello, Anna Gouin, Camille Chaubet, Nassim Kamar, Emmanuel Treiner   +4 more
doaj   +2 more sources