Results 21 to 30 of about 5,468 (152)

Simulated microgravity increases CD226+Lin−CD117−Sca1+ mesenchymal stem cells in mice

Physiological Reports
Microgravity is one of the most common causes counting for the bone loss. Mesenchymal stem cells (MSCs) contribute greatly to the differentiation and function of bone related cells.
Wenjing Zhou, Yi Li, Yongli Hou, Wenli Dan, Lihua Chen, Fei Shi, Fang Zhao, Liang Fang   +7 more
doaj   +2 more sources

Genome-Wide Association Study Demonstrates the Role Played by the CD226 Gene in Rasa Aragonesa Sheep Reproductive Seasonality [PDF]

Animals, 2021
A genome-wide association study (GWAS) was used to identify genomic regions influencing seasonality reproduction traits in Rasa Aragonesa sheep. Three traits associated with either ovarian function based on blood progesterone levels (total days of ...
Kenza Lakhssassi, Belén Lahoz, Pilar Sarto, Laura Pilar Iguácel, José Folch, José Luis Alabart, Malena Serrano, Jorge Hugo Calvo   +7 more
doaj   +2 more sources

Examination of the TIGIT, CD226, CD112, and CD155 Immune Checkpoint Molecules in Peripheral Blood Mononuclear Cells in Women Diagnosed with Early-Onset Preeclampsia [PDF]

Biomedicines, 2021
Early-onset preeclampsia is a common obstetrical disease with a potential genetic background and is characterized by the predominance of Th1 immune response.
Laszlo Szereday, David U. Nagy, Beata Csiszar, Dora Kevey, Timoteus Feik, Matyas Meggyes   +5 more
doaj   +2 more sources

CD226 gene polymorphisms are associated with non-small-cell lung cancer in the Chinese Han population

Therapeutics and Clinical Risk Management, 2015
Zhi-Xin Qiu,1,* Ying Peng,2,* Wei-Min Li1 1Department of Respiratory Medicine, 2Department of Cardiology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China *These authors contributed equally to this work ...
Qiu ZX, Peng Y, Li WM
doaj   +1 more source

Increased levels of soluble CD226 in sera accompanied by decreased membrane CD226 expression on peripheral blood mononuclear cells from cancer patients [PDF]

BMC Immunology, 2009
Background As a cellular membrane triggering receptor, CD226 is involved in the NK cell- or CTL-mediated lysis of tumor cells of different origin, including freshly isolated tumor cells and tumor cell lines.
Xu Zhuwei, Zhang Tao, Zhuang Ran, Zhang Yun, Jia Wei, Song Chaojun, Yang Kun, Yang Angang, Jin Boquan   +8 more
doaj   +2 more sources

Expression of the immune checkpoint molecules CD226 and TIGIT in preeclampsia patients

BMC Immunology
Background Imbalanced immune responses are involved in developing preeclampsia (PE). We wish to explore the expression and potential changes of immune checkpoint molecules TIGIT, CD226 and CD155 in PE patients.
Cui Li, Haiyan Liu, Zhongliang Duan
doaj   +2 more sources

Expansion of circulating peripheral TIGIT+CD226+ CD4 T cells with enhanced effector functions in dermatomyositis

Arthritis Research & Therapy, 2021
Background T cell Ig and ITIM domain (TIGIT)/CD226 pathway has a critical role in regulating T cell responses and has come to the forefront in cancer as a promising immunotherapeutic target.
Wenli Li, Chuiwen Deng, Hanbo Yang, Xin Lu, Shanshan Li, Xia Liu, Fang Chen, Lida Chen, Xiaoming Shu, Lu Zhang, Qingyan Liu, Guochun Wang, Qinglin Peng   +12 more
doaj   +1 more source

CD226 Is Required to Maintain Megakaryocytes/Platelets Homeostasis in the Treatment of Knee Osteoarthritis With Platelet-Rich Plasma in Mice

Frontiers in Pharmacology, 2021
Platelet-rich plasma (PRP) is a platelet-based application used to treat osteoarthritis (OA) clinically. The co-stimulatory molecule CD226 is expressed in T cells, NK cells, and also platelets. However, exact effects of CD226 on platelets and whether its
Yongming Liu, Yuan Zhang, Jinxue Zhang, Jingchang Ma, Ka Bian, Yuling Wang, Xuexue Xu, Shuwen Wu, Kun Cheng, Yun Zhang, Yong Ding, Yong Zhou, Ran Zhuang, Ran Zhuang   +13 more
doaj   +1 more source

Imbalance of the CD226/TIGIT Immune Checkpoint Is Involved in the Pathogenesis of Primary Biliary Cholangitis

Frontiers in Immunology, 2020
The relationship between the cluster of differentiation 226 (CD226)/T cell Ig and ITIM domain (TIGIT) immune checkpoint and primary biliary cholangitis (PBC) pathogenesis is unknown.
Chuiwen Deng, Wenli Li, Yunyun Fei, Li Wang, Yingying Chen, Xiaofeng Zeng, Fengchun Zhang, Yongzhe Li   +7 more
doaj   +1 more source

CD226: An Emerging Role in Immunologic Diseases

Frontiers in Cell and Developmental Biology, 2020
CD226, a member of the immunoglobulin superfamily, is a functional protein initially expressed on natural killer and T cells. In recent years, the function of CD226 has been increasingly realized and researched.
Zhiyi Huang, Guangyin Qi, Joseph S. Miller, Song Guo Zheng   +3 more
doaj   +1 more source