Endogenous CD155 drives metabolic reprogramming via PI3K/AKT/HIF‐1α‐glycolysis axis to mediate anti‐PD‐1 resistance in non‐small cell lung cancer [PDF]
Clinical and Translational MedicineObjective Anti‐PD‐1 therapy resistance remains a critical barrier in non‐small cell lung cancer (NSCLC) management, and the underlying mechanisms are incompletely defined.
Wei‐Guang Du +11 more
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CD155 Promotes the Progression of Cervical Cancer Cells Through AKT/mTOR and NF-κB Pathways
Frontiers in Oncology, 2021 Expression of the immunoglobulin superfamily member CD155 was increased in a variety of human malignancies, but the role of CD155 in tumorigenesis and tumor development in cervical cancer has not been elucidated.
Wei Lu, Youzhong Zhang, Lu Liu
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The PVR-TIGIT/CD96/CD226 axis: a novel immune checkpoint target in ovarian cancer [PDF]
Frontiers in ImmunologyThe poliovirus receptor (CD155) is an emerging immune checkpoint molecule involved in the suppression of anti-tumor immunity. In ovarian cancer, CD155 is frequently overexpressed and interacts with receptors such as TIGIT, CD96, and CD226 to modulate the
Mingyao Huang +4 more
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Cancer Immunology, ImmunotherapyBackground CD155 is a crucial factor in the regulation of T cell function and contributes to immune escape. CD155 upregulation has been found in several types of cancer.
Dongbing Ding, Yiquan Li
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Interferon-elicited lipoprotein metabolism in lung fibroblasts facilitates premetastatic niche formation [PDF]
Nature CommunicationsWhile premetastatic niche formation is known to affect primary tumors lung metastases, the role of lung stromal cells in this process remains unclear.
Jian Gao +14 more
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Signal Transduction and Targeted TherapyThis study presents a novel approach targeting CD155, an overexpressed protein in lung adenocarcinoma (LUAD), using nanobodies with exceptional precision and efficacy.
Juyeon Jung +2 more
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Dual targeting of CD155 augments the antitumor efficacy of ROR1-CAR-T cells in ovarian cancer [PDF]
Cancer Immunology, ImmunotherapyBackground Exploring novel therapeutic targets and developing targeted therapies constitute an urgent clinical need for improving the prognosis of ovarian cancer (OC), particularly among patients with advanced stages. Currently, chimeric antigen receptor
Yingjun Ye +6 more
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CD155 and its receptors in glioma: prospects for emerging immune checkpoint inhibitors [PDF]
Acta Neuropathologica CommunicationsGlioma is an aggressive brain malignancy characterized by a markedly immunosuppressive microenvironment and limited response to conventional treatments.
Mingyao Huang +7 more
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CD155 reprograms glycolysis via the YAP/TEAD1-GLUT1 axis to promote lung adenocarcinoma progression and M2 macrophage polarization: a metabolic-immune target visualized by 18F-FDG PET/CT [PDF]
Journal of Translational MedicineBackground CD155, an emerging immune checkpoint, contributes to tumor immune evasion and progression, but its roles in metabolic reprogramming and tumor-associated macrophages (TAMs) polarization in lung adenocarcinoma (LUAD) remain uncharacterized. This
Zhiming Cheng +7 more
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Immunohistochemical analysis of CD155 expression in triple-negative breast cancer patients.
PLoS ONE, 2021 IntroductionCD155 is an immune checkpoint protein. Its overexpression is an indicator of poor prognosis in some types of cancer. However, the significance of CD155 expression in patients with triple-negative breast cancer, and the relationship between ...
Katsuhiro Yoshikawa +5 more
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