Results 31 to 40 of about 5,434 (169)

CD155-Prognostic and Immunotherapeutic Implications Based on Multiple Analyses of Databases Across 33 Human Cancers

Technology in Cancer Research & Treatment, 2021
Growing evidence has suggested that CD155 participates in the regulation of many biological processes ranging cell growth, invasion, and migration from regulation of immune responses in most malignances.
Hongpan Zhang MD, Zhihao Yang MD, Guobo Du MD, Lu Cao MD, BangXian Tan MD   +4 more
doaj   +1 more source

Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice. [PDF]

PLoS ONE, 2014
Tumor recognition by immune effector cells is mediated by antigen receptors and a variety of adhesion and costimulatory molecules. The evidence accumulated since the identification of CD155 and CD112 as ligands for DNAM-1 in humans and mice has suggested
Yoko Nagumo, Akiko Iguchi-Manaka, Yumi Yamashita-Kanemaru, Fumie Abe, Günter Bernhardt, Akira Shibuya, Kazuko Shibuya   +6 more
doaj   +1 more source

Anticancer activity of emodin is associated with downregulation of CD155

International Immunopharmacology, 2019
Emodin is a Chinese herb-derived compound that exhibits a variety of pharmacological benefits. Although emodin has been shown to inhibit growth of cancer cells, its antineoplastic function is incompletely understood. CD155 is a member of poliovirus receptor-related (PRR) family of adhesion molecules; it is constitutively expressed on many tumor cell ...
Liang, Fang, Fang, Zhao, Stephen, Iwanowycz, Junfeng, Wang, Sophia, Yin, Yuzhen, Wang, Daping, Fan   +6 more
openaire   +3 more sources

Structure of MHC-Independent TCRs and Their Recognition of Native Antigen CD155 [PDF]

The Journal of Immunology, 2020
Abstract During normal T cell development in the thymus, αβ TCRs signal immature thymocytes to differentiate into mature T cells by binding to peptide–MHC ligands together with CD4/CD8 coreceptors. Conversely, in MHC and CD4/CD8 coreceptor-deficient mice, the thymus generates mature T cells expressing MHC-independent TCRs that recognize ...
Jinghua Lu, François Van Laethem, Ingrid Saba, Jonathan Chu, Anastasia N Tikhonova, Abhisek Bhattacharya, Alfred Singer, Peter D Sun   +7 more
openaire   +2 more sources

Overexpression of CD155 relates to metastasis and invasion in osteosarcoma

Oncology Letters, 2018
The rapid development of metastatic lesions remains the leading cause of mortality for patients with osteosarcoma. CD155 serves a key role in cancer cell migration, invasion and metastasis. However, the function and mechanism of CD155 has not been explored in osteosarcoma metastasis.
Baobiao, Zhuo, Yuan, Li, Feng, Gu, Zhengwei, Li, Qingzeng, Sun, Yingchun, Shi, Yang, Shen, Fengfei, Zhang, Rong, Wang, Xiaodong, Wang   +9 more
openaire   +3 more sources

Prognostic and clinicopathological significance of CD155 expression in cancer patients: a meta-analysis

World Journal of Surgical Oncology, 2022
Background It has been previously reported that CD155 is often over-expressed in a variety of cancer types. In fact, it is known to be involved in cancer development, and its role in cancer has been widely established.
Dan Zhang, Jingting Liu, Mengxia Zheng, Chunyan Meng, Jianhua Liao   +4 more
doaj   +1 more source

CD155 Overexpression Correlates With Poor Prognosis in Primary Small Cell Carcinoma of the Esophagus

Frontiers in Molecular Biosciences, 2021
CD155/TIGIT overexpression has been detected in various human malignancies; however, its expression status in primary small cell carcinoma of the esophagus (PSCCE) and its prognostic significance remain unclear.
Kaikai Zhao, Kaikai Zhao, Lin Ma, Lei Feng, Zhaoqin Huang, Xiangjiao Meng, Jinming Yu   +6 more
doaj   +1 more source

Targeting PVR (CD155) and its receptors in anti-tumor therapy [PDF]

Cellular & Molecular Immunology, 2018
Poliovirus receptor (PVR, CD155) has recently been gaining scientific interest as a therapeutic target in the field of tumor immunology due to its prominent endogenous and immune functions. In contrast to healthy tissues, PVR is expressed at high levels in several human malignancies and seems to have protumorigenic and therapeutically attractive ...
Paola Kučan Brlić, Tihana Lenac Roviš, Guy Cinamon, Pini Tsukerman, Ofer Mandelboim, Stipan Jonjić   +5 more
openaire   +5 more sources

CD96 targeted antibodies need not block CD96-CD155 interactions to promote NK cell anti-metastatic activity

OncoImmunology, 2018
CD96 is a transmembrane glycoprotein Ig superfamily receptor, expressed on various T cell subsets and NK cells, that interacts with nectin and nectin-like proteins, including CD155/polio virus receptor (PVR).
Amelia Roman Aguilera, Viviana P. Lutzky, Deepak Mittal, Xian-Yang Li, Kimberley Stannard, Kazuyoshi Takeda, Günter Bernhardt, Michele W. L. Teng, William C. Dougall, Mark J. Smyth   +9 more
doaj   +1 more source

Increased Soluble CD155 in the Serum of Cancer Patients

PLOS ONE, 2016
Emerging evidence suggests that DNAM-1 (CD226) play an important role in the recognition of tumor cells and their lysis by cytotoxic T lymphocytes (CTL) and NK cells. Although the DNAM-1 ligand CD155 is ubiquitously expressed in various tissues, many human tumors significantly upregulate the expression of CD155; DNAM-1 on CTL and NK cells may be ...
Akiko Iguchi-Manaka, Genki Okumura, Hiroshi Kojima, Yukiko Cho, Rei Hirochika, Hiroko Bando, Toyomi Sato, Hiroyuki Yoshikawa, Hisato Hara, Akira Shibuya, Kazuko Shibuya   +10 more
openaire   +4 more sources