Results 41 to 50 of about 5,434 (169)

PVR (CD155) Expression as a Potential Prognostic Marker in Multiple Myeloma

Biomedicines, 2022
Abstract Poliovirus receptor (PVR, CD155) is upregulated during tumor progression, and PVR expression is associated with poor prognosis in patients with cancer; however, prognostic implications for PVR in multiple myeloma (MM) have not been investigated. We assessed PVR expression in bone marrow samples of 125 patients via immunohistochemistry (
Byung-Hyun Lee, Ji-Hea Kim, Ka-Won Kang, Se-Ryeon Lee, Yong Park, Hwa-Jung Sung, Byung-Soo Kim   +6 more
openaire   +3 more sources

CD155 immunoregulation as a target for natural killer cell immunotherapy in glioblastoma [PDF]

Journal of Hematology & Oncology, 2020
AbstractNatural killer (NK) cells are powerful immune effectors, modulating their anti-tumor function through a balance activating and inhibitor ligands on their cell surface. Though still emerging, cancer immunotherapies utilizing NK cells are proving promising as a modality for the treatment of a number of solid tumors, including glioblastoma (GBM ...
Kyle B. Lupo, Sandro Matosevic
openaire   +3 more sources

Blocking TIGIT/CD155 signalling reverses CD8+ T cell exhaustion and enhances the antitumor activity in cervical cancer

Journal of Translational Medicine, 2022
Objective TIGIT/CD155 has attracted widespread attention as a new immune checkpoint and a potential target for cancer immunotherapy. In our study, we evaluated the role of TIGIT/CD155 checkpoints in the progression of cervical cancer.
Lu Liu, Aihong Wang, Xiaoli Liu, Sai Han, Yu Sun, Junhua Zhang, Lingyu Guo, Youzhong Zhang   +7 more
doaj   +1 more source

CD86‐Positive Mature Tertiary Lymphoid Structures Are Associated With CD8+ T‐Cell Infiltration and Favorable Clinical Outcomes in Pancreatic Ductal Adenocarcinoma

Annals of Gastroenterological Surgery, EarlyView.
CD86‐positive mature tertiary lymphoid structures were associated with increased intratumoral CD8+ T‐cell infiltration, a higher proportion of Granzyme B‐expressing CD8+ T cells in an exploratory analysis, and favorable clinical outcomes in pancreatic ductal adenocarcinoma.
Takaomi Seki, Kenichiro Araki, Takehiko Yokobori, Hayato Ikota, Norio Kubo, Takamichi Igarashi, Mariko Tsukagoshi, Norihiro Ishii, Yasuo Hosouchi, Hiroshi Saeki, Ken Shirabe   +10 more
wiley   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source

The Dual Face of Fusobacterium nucleatum in Cancer: Foe, Friend or Both?

Journal of Periodontal Research, EarlyView.
Fusobacterium nucleatum has established interactions with cancers in humans. However, contrary to a traditional view that these interactions are uniformly pro‐tumoural, recent evidence suggests a more nuanced role, where contact‐dependent and contact‐independent mechanisms may support either tumour progression or restriction depending on tumour site ...
Anjali Chander, Huile Lim, Gilad Bachrach, Miguel Reis Ferreira   +3 more
wiley   +1 more source

Cross‐Neutralizing and Broadly Neutralizing Human Antibodies Against Nonenveloped Viruses

European Journal of Immunology, Volume 56, Issue 10, October 2026.
In this review article, Marchand et al. compare cross ‐ and broadly ‐neutralizing human antibodies against non ‐ enveloped viruses from several major families, discussing their structural characteristics, neutralization mechanisms and relevance for the development of antiviral vaccines and therapeutics.
Sarah Marchand, Samy Taouli, Dorian McIlroy   +2 more
wiley   +1 more source

CD155-based chimeric antigen receptor T cells: a promising immunotherapy for cervical and breast cancer

Frontiers in Immunology
IntroductionAs an immune checkpoint molecule that is overexpressed in cervical and breast cancer, CD155 represents an attractive target for chimeric antigen receptor (CAR) T-cell therapy.
Jun Ma, Jun Ma, Jun Ma, Wenjing Zhu, Wenjing Zhu, Rui Zhao, Rui Zhao, Qianqian Shi, Qianqian Shi, Qianqian Shi, Fang Yang, Fang Yang, Fang Yang, Yangnan Ding, Yangnan Ding, Yangnan Ding, Enwu Yuan, Enwu Yuan, Enwu Yuan, Enwu Yuan, Kai Zhang, Kai Zhang, Kai Zhang, Xin Zhao, Xin Zhao   +24 more
doaj   +1 more source

The Role of T Cell Costimulation via DNAM-1 in Kidney Transplantation. [PDF]

PLoS ONE, 2016
DNAX accessory protein-1 (DNAM-1, CD226) is a co-stimulatory and adhesion molecule expressed mainly by natural killer cells and T cells. DNAM-1 and its two ligands CD112 and CD155 are important in graft-versus-host disease, but their role in solid organ ...
Anna K Kraus, Jin Chen, Ilka Edenhofer, Inga Ravens, Ariana Gaspert, Pietro E Cippà, Steffen Mueller, Rudolf P Wuthrich, Stephan Segerer, Guenter Bernhardt, Thomas Fehr   +10 more
doaj   +1 more source

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies

MedComm, Volume 7, Issue 10, October 2026.
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao, Wenchao Xu, Yibo Wang, Haoran Huang, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +7 more
wiley   +1 more source