Results 11 to 20 of about 5,434 (169)

Prognostic value of CD155/TIGIT expression in patients with colorectal cancer.

PLoS ONE, 2022
IntroductionThe interaction of CD155 with its ligand, the T cell immunoreceptor with Ig and ITIM domains (TIGIT), is being studied owing to its potential to act as a target in the treatment of various solid tumors. However, the relationship between CD155
Daisuke Murakami, Kenji Matsuda, Hiromitsu Iwamoto, Yasuyuki Mitani, Yuki Mizumoto, Yuki Nakamura, Ibu Matsuzaki, Ryuta Iwamoto, Yuichi Takahashi, Fumiyoshi Kojima, Shin-Ichi Murata, Hiroki Yamaue   +11 more
doaj   +3 more sources

Integrative Omics Analysis Reveals a CD206⁺ Macrophage/Dendritic Cell-CD155-TIGIT⁺ Regulatory T Cell Axis as a Protective Immune Checkpoint Pathway in Atherosclerosis Progression. [PDF]

Barrier Immun
ABSTRACT RNA sequencing (RNA‐seq) analysis revealed transcriptional features indicative of sustained immunosuppression within regulatory T cells (Tregs) isolated from atherosclerotic tissues, highlighting the critical contribution of immune checkpoint (ICP) receptor–ligand interactions to atherosclerosis progression. To comprehensively characterize the
Shao Y, Saaoud F, Issa MB, Xu K, Lu Y, Hung SY, Liu J, Yuan B, Wei J, Wu S, Mohsin S, Zhou Z, Kosmider B, Martinez L, Vazquez-Padron R, Wang H, Yang X.   +16 more
europepmc   +2 more sources

CD155 as a prognostic and predictive biomarker in acute myeloid leukemia

Discover Oncology
Background Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy with different molecular and genetic alterations. CD155 is expressed on myeloid cells and serves as a recognition molecule for natural killer (NK) cells to induce ...
Ashraf Zeidan Abdalla, Salah Mabrouk Khallaf, Asmaa Mohammed Zahran, Nehal Adel Rayan, Ahmed Refaat Abd Elzaher   +4 more
doaj   +3 more sources

Tumor-associated macrophage-specific CD155 contributes to M2-phenotype transition, immunosuppression, and tumor progression in colorectal cancer

Journal for ImmunoTherapy of Cancer, 2022
Background Onco-immunogenic molecule CD155 is overexpressed in various tumor microenvironments (TME) including in colorectal cancer (CRC). Tumor-associated macrophages (TAMs) are the most abundant immune cells in CRC TME and play a vital role in CRC ...
Yong Huang, Xudong Zhu, Bo Wei, Rongpu Liang, Tianyun Lan, Dongbing Ding, Shengxin Huang, Jun Shao, Zongheng Zheng, Tufeng Chen, Jianpei Liu, Janak L Pathak, Hongbo Wei   +12 more
doaj   +1 more source

CD155

, 2022
Esophageal cancer is the sixth leading cause of death (4%) among all tumors in males, China has the largest number of esophageal cancer patients in the world, with about 193,000 deaths per year, 90% of which are esophageal squamous cell cancer (ESCA).
  +4 more sources

CD155: A Multi-Functional Molecule in Tumor Progression [PDF]

International Journal of Molecular Sciences, 2020
CD155 is an adhesion molecule belonging to the Nectin/Nectin-like family often overexpressed on tumor cells and involved in many different processes such as cell adhesion, migration and proliferation. In contrast to these pro-tumorigenic functions, CD155 is also a ligand for the activating receptor DNAM-1 expressed on cytotoxic lymphocytes including ...
Molfetta R., Zitti B., Lecce M., Milito Nadia Domenica, Stabile H., Fionda C., Cippitelli M., Gismondi A., Santoni A., Paolini R.   +9 more
openaire   +2 more sources

Clinical significance of CD155 expression and correlation with cellular components of tumor microenvironment in gastric adenocarcinoma

Frontiers in Immunology, 2023
IntroductionCD155 is recently emerging as a promising target in malignancies. However, the relationship between CD155 expression and tumor microenvironment (TME) cell infiltration in gastric adenocarcinoma (GAC) has rarely been clarified.MethodsWe ...
Xue Liu, Xue Liu, Chenyang Xu, Chenyang Xu, Tianwei Guo, Shenghua Zhan, Qiuying Quan, Mengsi Li, Mengsi Li, Ziyi Wang, Ziyi Wang, Xueguang Zhang, Xueguang Zhang, Xueguang Zhang, Lingchuan Guo, Lei Cao, Lei Cao, Lei Cao   +17 more
doaj   +1 more source

CD155/SRC complex promotes hepatocellular carcinoma progression via inhibiting the p38 MAPK signalling pathway and correlates with poor prognosis

Clinical and Translational Medicine, 2022
Background Hepatocellular carcinoma (HCC) is a prevalent malignancy with poor prognosis. As a cell adhesion molecule, poliovirus receptor (PVR/CD155) is abnormally overexpressed in tumour cells, and related to tumour proliferation and invasion.
An‐Li Jin, Chun‐Yan Zhang, Wen‐Jing Zheng, Jing‐Rong Xian, Wen‐Jing Yang, Te Liu, Wei Chen, Tong Li, Bei‐Li Wang, Bai‐Shen Pan, Qian Li, Jian‐Wen Cheng, Peng‐Xiang Wang, Bo Hu, Jian Zhou, Jia Fan, Xin‐Rong Yang, Wei Guo   +17 more
doaj   +1 more source

CD155 promotes radioresistance and malignancy of esophageal cancer by regulating Hippo-YAP pathway

Discover Oncology, 2022
The expression of CD155 has been observed to increase in various human cancers, but its role in the development of esophageal cancer (EC) is unclear. Radiotherapy is one of the primary therapeutic options for EC.
Huixian Xin, Yuchen Liu, Pengxiang Chen, Tianwen Yin, Meijie Wang, Tianyu Liu, Zhihua Wen, Yufeng Cheng   +7 more
doaj   +1 more source

MD Simulation Reveals Regulation of Mechanical Force and Extracellular Domain 2 on Binding of DNAM-1 to CD155

Molecules, 2023
Two extracellular domains of the adhesive receptor DNAM-1 are involved in various cellular biological processes through binding to ligand CD155, usually under a mechano-microenvironment. The first extracellular domain (D1) plays a key role in recognition,
Liping Fang, Yang Zhao, Pei Guo, Ying Fang, Jianhua Wu   +4 more
doaj   +1 more source