Results 41 to 50 of about 5,468 (152)

Expression of CD226 in preeclamptic placentas and its role in trophoblast function [PDF]

Yixue xinzhi zazhi
Objective To analyze the expression characteristics of CD226 in placental tissues from preeclampsia (PE) patients and its biological function in trophoblast cells.Methods CD226 mRNA transcript levels and protein expression in placental tissues from the ...
YU Yang, BAI Jinbo, FENG Dan, XU Xiaoyan, WANG Bo, LIU Zekun, ZHANG Ming   +6 more
doaj   +1 more source

Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals [PDF]

, 2017
HIV-specific CD8+ T cells demonstrate an exhausted phenotype associated with increased expression of inhibitory receptors, decreased functional capacity, and a skewed transcriptional profile, which are only partially restored by antiretroviral treatment (
Deeks, Steven G, Ljunggren, Hans-Gustaf, Frederiksen, Juliet, Scharf, Lydia, Tauriainen, Johanna, Naji, Ali, Sönnerborg, Anders, Buggert, Marcus, Hecht, Frederick M, Betts, Michael R, Reyes-Terán, Gustavo, Karlsson, Annika C, Lund, Ole, Lund, O, Hecht, FM, Reyes-Teran, G, Ljunggren, H-G, Scharf, L,, Frederiksen, J, Naji, A, Deeks, SG, Tauriainen, J, Sonnerborg, A   +22 more
core   +1 more source

Additional file 1 of CD226 knockout alleviates high-fat diet induced obesity by suppressing proinflammatory macrophage phenotype

, 2021
Additional file 1: Figure S1. Expression of macrophage CD226 increased under inflammatory conditions. (A) Cd226 mRNA levels in the epididymal fat and SVF of mice fed chow or a HFD for 16 weeks.
Yuling Wang (168167), Dongliang Zhang (752677), Xuexue Xu (5987240), Jingchang Ma (10328591), Jiangang Xie (11757668), Yitian Liu (185427), Chujun Duan (11757671), Kun Cheng (1395379), Boquan Jin (383395), Wei Hu (6560), Ran Zhuang (11757674), Yuan Zhang (41832)   +11 more
core   +1 more source

Perturbed CD8⁺ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals [PDF]

, 2017
HIV-specific CD8+ T cells demonstrate an exhausted phenotype associated with increased expression of inhibitory receptors, decreased functional capacity, and a skewed transcriptional profile, which are only partially restored by antiretroviral treatment (
Ljunggren, Hans-Gustaf, Deeks, Steven G., Karlsson, Annika C., Hecht, Frederick Mm, Frederiksen, Juliet, Scharf, Lydia, Tauriainen, Johanna, Naji, Ali, Betts, Michael R., Sönnerborg, Anders, Buggert, Marcus, Reyes-Terán, Gustavo, Lund, Ole   +12 more
core   +1 more source

CD226 knockout alleviates high-fat diet induced obesity by suppressing proinflammatory macrophage phenotype

Journal of Translational Medicine, 2021
Obesity is associated with chronic low-grade inflammation, contributing to an increasing prevalence of chronic metabolic diseases, such as insulin resistance, non-alcoholic fatty liver disease (NALFD), and steatohepatitis. Macrophages are the predominant
Jingchang Ma, Wei Hu, Dongliang Zhang, Jiangang Xie, Chujun Duan, Yitian Liu, Yuling Wang, Xuexue Xu, Kun Cheng, Boquan Jin, Yuan Zhang, Ran Zhuang   +11 more
doaj   +1 more source

Expression of TIGIT in splenic and circulatory T cells from mice acutely infected with Toxoplasma gondii

Parasite, 2021
The surface protein TIGIT (T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain) has been characterized as an important regulator of cell-mediated immune responses in various infections.
Wang Shuai, Li Haoran, Zhang Fuqiang, Jiao Yuankai, Xie Qing, Zhang Zhenchao, Li Xiangrui   +6 more
doaj   +1 more source

Differential expression of CD226 in amyotrophic lateral sclerosis.

, 2022
Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2).
Shahan Mamoor
core   +1 more source

LncRNA MIR155HG functions as a ceRNA for inhibition of lung adenocarcinoma growth and prediction of prognosis

Archives of Medical Science, 2021
Introduction Long non-coding RNAs (lncRNAs) functioning as competing endogenous RNAs (ceRNAs) play critical roles in tumour progression. However, prognosis-related ceRNA networks in lung adenocarcinoma (LUAD) have not been well characterised.
Jing Wang, Jie Li
doaj   +1 more source

Human CD4+CD25+CD226- Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4+CD25+CD127lo/- Tregs for Adoptive Cell Therapy

Frontiers in Immunology, 2022
Regulatory T cell (Treg) adoptive cell therapy (ACT) represents an emerging strategy for restoring immune tolerance in autoimmune diseases. Tregs are commonly purified using a CD4+CD25+CD127lo/- gating strategy, which yields a mixed population: 1) cells ...
Matthew E. Brown, Leeana D. Peters, Seif R. Hanbali, Juan M. Arnoletti, Lindsey K. Sachs, Kayla Q. Nguyen, Emma B. Carpenter, Howard R. Seay, Howard R. Seay, Christopher A. Fuhrman, Christopher A. Fuhrman, Amanda L. Posgai, Melanie R. Shapiro, Todd M. Brusko, Todd M. Brusko   +14 more
doaj   +1 more source

Interleukin‐37 Enhances Liver NK Cell Cytotoxicity and Improves Recurrence‐Free Survival in Hepatocellular Carcinoma Patients

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Introduction Hepatocellular carcinoma (HCC) remains a major cause of cancer‐related mortality worldwide, and postoperative recurrence continues to limit long‐term survival. Liver‐resident natural killer (NK) cells are key effectors of antitumor immunity in the hepatic microenvironment. Interleukin‐37 (IL‐37), an anti‐inflammatory cytokine, has
Yuki Imaoka, Masahiro Ohira, Yuka Tanaka, Toshihiro Nakayama, Miho Akabane, Shinichiro Yokota, Sheri M. Krams, Olivia M. Martinez, Carlos O. Esquivel, Kazunari Sasaki, Hideki Ohdan   +10 more
wiley   +1 more source