Results 61 to 70 of about 5,468 (152)

CDS2 Drives Tumor Progression in Epithelial Ovarian Cancer via the PI3K/AKT Pathway

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Epithelial ovarian cancer (EOC) frequently disseminates within the lipid‐rich peritoneal cavity, where tumor progression is accompanied by metabolic adaptations involving lipid utilization and mitochondrial function. Although these metabolic alterations are increasingly recognized as important features of EOC progression and ...
Lixue Cao, Yanzhen Chen, Yingqi Liu, Changnian Yang, Zhentao Zhang, Yongqing Lin, Yiyuan Wang, Siman Chen, Fei Yu, Haiyan Ye, Shanshan Wu   +10 more
wiley   +1 more source

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Heterogeneous expression of the adhesion receptor CD226 on murine NK and T cells and its function in NK-mediated killing of immature dendritic cells.

, 2009
The adhesion receptor CD226 (DNAM-1) is a member of the Ig superfamily possessing two extracellular V-like domains. In humans, CD226 was shown to be expressed by NK as well as T cells.
Bernhardt, G., Seth, S., Qiu, Q., Chambers, B.J., Seth, S, Chambers, BJ, Foerster, R., Georgoudaki, A-M, Ravens, I, Ravens, I., Bernhardt, G, Maier, M.K., Foerster, R, Czeloth, N., Qiu, Q, Kremmer, E., Kremmer, E, Czeloth, N, Georgoudaki, A.M., Maier, MK   +19 more
core   +1 more source

Expression of CD226 is associated to but not required for NK cell education

Nature Communications, 2017
CD226 is an activating receptor expressed in a co-varied manner with inhibitory receptors on natural killer (NK) cells, but whether CD226 is involved in NK cell education is unclear. Here the authors show that CD226 expression is plastic depending on the
Arnika K. Wagner, Nadir Kadri, Johanna Snäll, Petter Brodin, Susan Gilfillan, Marco Colonna, Günter Bernhardt, Petter Höglund, Klas Kärre, Benedict J. Chambers   +9 more
doaj   +1 more source

Natural Killer Cell‐Derived Extracellular Vesicle Preparations Demonstrate Potent Antitumor Activity Against Human Glioblastoma In Vitro and In Vivo

Journal of Extracellular Biology, Volume 5, Issue 10, October 2026.
Schematic overview of NK‐EV isolation strategies from expanded primary human NK cells. Primary human NK cells were isolated from PBMCs and expanded using K562 feeder cells. EV‐containing preparations were then isolated from expanded NK‐cell cultures using two approaches. First, total exosome isolation reagent was used as a precipitation‐based method to
Huy Phuoc Quang Nguyen, Meesun Yoon, Shin Jung, Duck Cho, Byong Seung Cho, Tung Nguyen Thanh Uong, Jae‐Uk Jeong, Yong‐Hyub Kim, Nhat Phuoc Nguong Minh Nguyen, Tien Luyen Vu   +9 more
wiley   +1 more source

Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases

MedComm, Volume 7, Issue 10, October 2026.
This review delineates the multifaceted roles of natural killer (NK) cells in the central nervous system, spanning direct cytolysis, immunoregulation, and crosstalk with the brain microenvironment. We evaluate the translational potential and challenges of NK cell immunotherapies for a spectrum of neurological conditions.
Kaihang Deng, Wai Po Chong
wiley   +1 more source

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies

MedComm, Volume 7, Issue 10, October 2026.
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao, Wenchao Xu, Yibo Wang, Haoran Huang, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +7 more
wiley   +1 more source

Immune‐Cell Dynamics in the Tumor Microenvironment: Implications for Cancer Therapy

MedComm, Volume 7, Issue 10, October 2026.
Immune‐cell dynamics in the tumor microenvironment converge on four major barriers to effective therapy: failed immune access, defective antigen visibility and priming, loss of effector maintenance, and suppressive tissue remodeling. These barriers emerge from local hypoxic, cytokine, metabolic, and stromal signals.
Pin Guo, Yizhao Xie, Rui Song, Mengdi Yang, Zhen Lin, Chao Guan, Zechen Wang, Jin Wen, Guang‐Liang Chen   +8 more
wiley   +1 more source

A multicenter study confirms CD226 [PDF]

, 2012
Introduction: CD226 genetic variants have been associated with a number of autoimmune diseases and recently with systemic sclerosis (SSc). The aim of this study was to test the influence of CD226 loci in SSc susceptibility, clinical phenotypes and ...
Christopher P Denton, Bobby PC Koeleman, Carmen Fonseca, Patricia Carreira, Koeleman, Bobby P C, Lorenzo Beretta, Miguel A González-Gay, María Carmen Freire, Narváez, Javier, Beltrán, Emma, van Laar, Jacob M., Castillo, Maria J, González-Gay, Miguel A, Madelon C Vonk, Jacob M van Laar, Hoffmann-Vold, Anna Maria, Carlos Tolosa, Camps, María T, Ariane Herrick, Denton, Christopher P., Jasper C Broen, Gerard Espinosa, Emma Beltrán, Anna-Maria Hoffmann-Vold, Broen, Jasper C., Lara Bossini-Castillo, Witte, Torsten, Alexander Kreuter, Carreira, Patricia, Vonk, Madelon C, González-Gay, Miguel A., Timothy RDJ Radstake, null null, Simeon, Carmen P, Ríos-Fernández, Raquel, Koeleman, Bobby Pc, Chee, Meng M., Herrick, Ariane, Hesselstrand, Roger, Schuerwegh, Annemie J, Javier Narváez, Vonk, Madelon C., Fonseca, Carmen, Tolosa, Carlos, Maria J Castillo, Meng Chee, Carmen Freire, María D., Kreuter, Alexander, Schuerwegh, Annemie J., Espinosa, Gerard, Roger Hesselstrand, Denton, Christopher P, Annemie J Schuerwegh, Camps, María T., Raquel Ríos-Fernández, Beretta, Lorenzo, Javier Martin, Castillo, Maria J., Carmen Freire, María del, Torsten Witte, Simeon, Carmen P., Hoffmann-Vold, Anna-Maria, Lunardi, Claudio, Radstake, Timothy Rdj, Martin, Javier, Chee, Meng May, Carmen P Simeon, María del Carmen Freire, van Laar, Jacob M, Broen, Jasper C, Bossini-Castillo, Lara, Radstake, Timothy R D J, María T Camps, Claudio Lunardi   +73 more
core   +3 more sources

MicroRNA-378 protects human umbilical vein endothelial cells from injuries by soluble CD226 through down-regulating the expression of soluble CD226 in natural killer cells

Biotechnology & Biotechnological Equipment, 2019
This study aimed to determine the expression of microRNA (miRNA or miR)-378 in peripheral blood from patients with pregnancy-induced hypertension (PIH), and to try to understand its effect on vascular endothelial injuries induced by PIH.
Huiying Xu, Yu Du, Jing He, Liping Wang, Gaogao Sun   +4 more
doaj   +1 more source