Results 71 to 80 of about 5,468 (152)

Epstein-Barr Virus Induces Adhesion Receptor CD226 (DNAM-1) Expression during Primary B-Cell Transformation into Lymphoblastoid Cell Lines

mSphere, 2017
Epstein-Barr virus (EBV), an oncogenic herpesvirus, infects and transforms primary B cells into immortal lymphoblastoid cell lines (LCLs), providing a model for EBV-mediated tumorigenesis.
Lisa Grossman, Chris Chang, Joanne Dai, Pavel A. Nikitin, Dereje D. Jima, Sandeep S. Dave, Micah A. Luftig   +6 more
doaj   +1 more source

Impact of immune checkpoint gene CD155 Ala67Thr and CD226 Gly307Ser polymorphisms on small cell lung cancer clinical outcome

Scientific Reports, 2021
This study was conducted to investigate the impact of genetic variants of immune checkpoint genes on the treatment outcome in small cell lung cancer (SCLC). In the present study, 261 platinum doublet-treated SCLC patients were enrolled.
Jang Hyuck Lee, Seung Soo Yoo, Mi Jeong Hong, Jin Eun Choi, Soyoun Kim, Hyo-Gyoung Kang, Sook Kyung Do, Ji Hyun Kim, Sun Ah Baek, Won Kee Lee, Jae Do Yoo, Sun Ha Choi, Yong Hoon Lee, Hyewon Seo, Jaehee Lee, Shin Yup Lee, Seung Ick Cha, Chang Ho Kim, Jae Yong Park   +18 more
doaj   +1 more source

Functional and Proteomic Profiles of CD3(+) Plasma‐Derived Small Extracellular Vesicles Differentiate Cancer Patients From Healthy Donors

European Journal of Immunology, Volume 56, Issue 9, September 2026.
The graphical abstract illustrates MTEX‐driven reprogramming of CD3(+) T cells in patients with melanoma. ABSTRACT Small extracellular vesicles (sEV) released by T cells play a key role in immune regulation. Immune capture with anti‐CD3 antibodies was used to isolate and study T cell‐derived CD3(+)sEV from the plasma of patients with melanoma (MPs) or ...
Piotr Widlak, Jie Han, Alicja Gluszko, Justyna Mika, Aneta Zebrowska, Sujan Kumar Mondal, Marta Gawin, Yana G. Najjar, Joanna Polańska, Monika Pietrowska, Theresa L. Whiteside   +10 more
wiley   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, Volume 58, Issue 5, Page 1413-1444, September 2026.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

GW4869 Depletes Macrophages and Increases Number of Extracellular Vesicles in Murine Peritoneal Cavity Fluid

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Pharmacological strategies to modulate extracellular vesicle (EV) release in vivo are gaining traction, yet their broader effects on local immune microenvironments remain unclear. In this study, we assessed how repeated intraperitoneal (i.p.) dosing of the neutral sphingomyelinase inhibitor GW4869 reshapes the peritoneal cavity.
Johann Mar Gudbergsson, Pedro Henrique Gobira, Rodrigo Grassi‐Oliveira, Anders Etzerodt   +3 more
wiley   +1 more source

iPSC-derived NK cells engineered with CD226 effectively control acute myeloid leukemia

Experimental Hematology & Oncology
CD226 plays a vital role in NK cell cytotoxicity, interacting with its ligands on tumor targets. Acute myeloid leukemia (AML) cells have developed mechanisms to escape NK cell cytotoxicity, including inducing downregulation of CD226 on NK cells.
Runze Cai, Binyan Lu, Xiangyu Zhao, Shixin Zhou, Yang Li   +4 more
doaj   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

, 2014
CD96, CD226 (DNAM-1) and TIGIT belong to an emerging family of receptors that interact with nectin and nectin-like proteins. CD226 activates natural killer (NK) cell-mediated cytotoxicity, whereas TIGIT reportedly counterbalances CD226.
Gilfillan, Susan, Ritchie, David S., Colonna, Marco, Town, Liam, Smyth, Mark J., Souza-Fonseca-Guimaraes, Fernando, Chow, Melvyn T., Martinet, Ludovic, Andrews, Daniel M., Chan, Christopher J.   +9 more
core   +1 more source

Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis [PDF]

, 2010
Recent genetic studies have led to identification of numerous loci that are associated with susceptibility to autoimmune diseases. The strategy of using information from these studies has facilitated the identification of novel juvenile idiopathic ...
S Eyre, J Worthington, X Ke, P Martin, W Thomson, A Hinks, E Flynn, J Packham, A Barton, Martin, P., Barton, A., Gardner-Medwin, J. [CAPS and BSPAR study groups], UKRAG Consortium, Worthington, J., Thomson, W., Flynn, E., Packham, J., Hinks, A., British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group, Eyre, S., Ke, X., Childhood Arthritis Prospective Study (CAPS)   +21 more
core   +1 more source

Increased levels of circulating soluble CD226 in multiple sclerosis

International audienceBackground:The glycoprotein CD226 plays a key role in regulating immune cell function. Soluble CD226 (sCD226) is increased in sera of patients with several chronic inflammatory diseases but its levels in neuroinflammatory diseases ...
Morandi, Elena, Angles, Thibault, Saoudi, Abdelhadi, Mougenot, Madeline, Laviolette, Karl, Bernard, Isabelle, Cauboue, Pauline, Kari, Saniya, Bucciarelli, Florence, Nogueira, Leonor, Oster, Anne-Cecile, Pignolet, Béatrice, Thomas, Joelle, Bost, Chloé, Liblau, Roland, S, Astier, Anne, L   +15 more
core   +1 more source