Results 31 to 40 of about 5,468 (152)

CD226 identifies functional CD8+T cells in the tumor microenvironment and predicts a better outcome for human gastric cancer

Frontiers in Immunology, 2023
It is well-known that CD226 serves as a critical activating receptor on various immune cells, such as lymphocytes and monocytes, and it is suggested to promote anti-tumor immunity in the tumor microenvironment (TME).
Hao Huang, Hao Huang, Hao Huang, Ziyi Huang, Ziyi Huang, Ziyi Huang, Junwei Ge, Junwei Ge, Junwei Ge, Jiayi Yang, Jiayi Yang, Jiayi Yang, Junjun Chen, Junjun Chen, Junjun Chen, Bin Xu, Bin Xu, Bin Xu, Shaoxian Wu, Shaoxian Wu, Shaoxian Wu, Xiao Zheng, Xiao Zheng, Xiao Zheng, Lujun Chen, Lujun Chen, Lujun Chen, Xueguang Zhang, Xueguang Zhang, Xueguang Zhang, Jingting Jiang, Jingting Jiang, Jingting Jiang   +32 more
doaj   +1 more source

CD226 and TIGIT Cooperate in the Differentiation and Maturation of Human Tfh Cells

Frontiers in Immunology, 2022
Costimulation pathways play an essential role in T cell activation, differentiation, and regulation. CD155 expressed on antigen-presenting cells (APCs) interacts with TIGIT, an inhibitory costimulatory molecule, and CD226, an activating costimulatory ...
Motoko Yasutomi, Allison F. Christiaansen, Naoko Imai, Natalia Martin-Orozco, Christian V. Forst, Gang Chen, Hideki Ueno, Hideki Ueno, Hideki Ueno   +8 more
doaj   +1 more source

Treg-specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T Cell Stability

, 2023
Co-stimulation serves as a critical checkpoint for T cell activation, and several genetic variants affecting co-stimulatory pathways confer risk for autoimmune diseases.
Matthew E. Brown (246644), Puchong Thirawatananond (16871690), Juan M. Arnoletti (16871699), Melanie R. Shapiro (16871702), Todd M. Brusko (245287), Yi-Guang Chen (848628), Lindsey K. Sachs (16871697), Wen-I Yeh (68332), Amanda L. Posgai (828165)   +8 more
core   +1 more source

L'absence de CD226 caractérise des LT CD8+ hyporépondeurs au TCR et aux fonctions antitumorales défectueuses [PDF]

, 2019
Les lymphocytes cytotoxiques T CD8+ (LT CD8+) sont des cellules de l'immunité adaptative qui jouent un rôle majeur dans les réponses immunitaires antitumorales puisqu'ils reconnaissent et tuent spécifiquement les cellules cancéreuses.
Weulersse, Marianne
core   +2 more sources

CD226 Attenuates Treg Proliferation via Akt and Erk Signaling in an EAE Model

Frontiers in Immunology, 2020
Cluster of differentiation 226 (CD226) molecules play a crucial role in the activation of effector CD4+ T cells during the immune response process, but a cell-intrinsic function of CD226 in CD4+ T subsets is not clear. In this study, we showed that Cd226−
Ning Wang, Ning Wang, Hongyu Yi, Liang Fang, Jingyi Jin, Qianli Ma, Yuting Shen, Juan Li, Shuang Liang, Jie Xiong, Zhuo Li, Hanyu Zeng, Fengliang Jiang, Boquan Jin, Lihua Chen   +14 more
doaj   +1 more source

CD8+ T lymphocytes are sensitive to NKG2A/HLA-E licensing interaction: role in the survival of cancer patients

OncoImmunology, 2021
NK and CD8+ T cells are the main cytolytic effectors involved in innate and adaptive tumor immune surveillance, respectively. Although their educational pathways differ, similarities in their development and function suggest that CD8+ T lymphocytes could
Lourdes Gimeno, Isabel González-Lozano, María F. Soto-Ramírez, María V. Martínez-Sánchez, Pedro López-Cubillana, José L. Fuster, Jerónimo Martínez-García, Jorge Martínez-Escribano, José A. Campillo, Eduardo Pons-Fuster, Belén Ferri, Alicia López-Abad, Manuel Muro, Alfredo Minguela   +13 more
doaj   +1 more source

Cd226−/− natural killer cells fail to establish stable contacts with cancer cells and show impaired control of tumor metastasis in vivo

OncoImmunology, 2017
CD226 is an activating receptor expressed on natural killer (NK) cells, CD8+ T cells, and other immune cells. Upon binding to its ligands expressed on target cells, CD226 activates intracellular signaling that triggers cytokine production and ...
Ji Sung Kim, Bo Ram Shin, Hong Kyung Lee, Jae Hee Lee, Ki Hun Kim, Jeong Eun Choi, A Young Ji, Jin Tae Hong, Youngsoo Kim, Sang-Bae Han   +9 more
doaj   +1 more source

The immunomodulatory molecule TIGIT is expressed by chronic lymphocytic leukemia cells and contributes to anergy

Haematologica, 2023
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory checkpoint receptor that negatively regulates Tcell responses. CD226 competes with TIGIT for binding to the CD155 ligand, delivering a positive signal to the T cell. Here we studied
Francesca Arruga, Marta Rubin, Despoina Papazoglou, Andrea Iannello, Nikolaos Ioannou, Riccardo Moia, Davide Rossi, Gianluca Gaidano, Marta Coscia, Luca Laurenti, Giovanni D’Arena, John N. Allan, Richard R. Furman, Tiziana Vaisitti, Alan G. Ramsay, Silvia Deaglio   +15 more
doaj   +1 more source

CD226 Deficiency Alleviates Murine Allergic Rhinitis by Suppressing Group 2 Innate Lymphoid Cell Responses

Mediators of Inflammation, 2022
Allergic rhinitis (AR) is an immunoglobulin E-mediated type 2 inflammation of the nasal mucosa that is mainly driven by type 2 helper T cells (Th2) and type 2 innate lymphoid cells (ILC2s).
Yang Xie, Yuan Zhang, Tianxiao Zhu, Jingchang Ma, Chujun Duan, Lu Yang, Tingting Wang, Ran Zhuang, Ka Bian, Lianjun Lu   +9 more
doaj   +1 more source

Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions [PDF]

International audienceBackground and ObjectivesThe rs763361 nonsynonymous variant in the CD226 gene, which results in a glycine-to-serine substitution at position 307 of the CD226 protein, has been implicated as a risk factor of various immune-mediated ...
Nunez, Nicolas, Morandi, Elena, Astier, Anne Laurence, Saoudi, Abdelhadi, Friebel, Ekaterina, Bernard, Isabelle, Masson, Frederick, Becher, Burkhard, Martinet, Ludovic, Adoue, Véronique, Dejean, Anne, S, Aubert, Yann   +11 more
core   +2 more sources