Results 41 to 50 of about 26,086 (200)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

The immunomodulatory molecule TIGIT is expressed by chronic lymphocytic leukemia cells and contributes to anergy [PDF]

, 2023
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory checkpoint receptor that negatively regulates Tcell responses. CD226 competes with TIGIT for binding to the CD155 ligand, delivering a positive signal to the T cell.
Ramsay, Alan G, Marta Coscia, John N. Allan, Riccardo Moia, Rubin, Marta, Allan, John N, Francesca Arruga, Gaidano, Gianluca, Rossi, Davide, D'Arena, Giovanni, Laurenti, Luca, Furman, Richard R, Luca Laurenti, Moia, Riccardo, Ramsay, Alan G., Ioannou, Nikolaos, Allan, John N., Nikolaos Ioannou, Furman, Richard R., Vaisitti, Tiziana, Davide Rossi, Silvia Deaglio, Andrea Iannello, Giovanni D’Arena, Arruga, Francesca, Richard R. Furman, Despoina Papazoglou, Tiziana Vaisitti, Gianluca Gaidano, Deaglio, Silvia, Coscia, Marta, Alan G. Ramsay, Papazoglou, Despoina, Iannello, Andrea, Marta Rubin, D’Arena, Giovanni   +35 more
core   +1 more source

TIGIT Signaling Pathway Regulates Natural Killer Cell Function in Chronic Hepatitis B Virus Infection

Frontiers in Medicine, 2022
Background and ObjectivePersistent infection of hepatitis B virus (HBV) and liver damage in immune active chronic hepatitis B (CHB) could be partly due to the overreaction of natural killer (NK) cells, including pro-inflammatory cytokine secretion and ...
Juan Wang, Hongyan Hou, Lie Mao, Feng Wang, Jing Yu, Ying Luo, Qun Lin, Ziyong Sun   +7 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease [PDF]

, 2016
T cell Ig and ITIM domain receptor (TIGIT), expressed on T, NK, and regulatory T cells, is known as an inhibitory molecule that limits autoimmunity, antiviral and antitumor immunity. In this report, we demonstrate that TIGIT enhances Th2 immunity.
Kourepini, Evangelina, Paschalidis, Nikolaos, Grogan, Jane, Panoutsakopoulou, Vily, Camargo Madeira Simoes, Davina, Aggelakopoulou, Maria   +5 more
core   +1 more source

TIGIT blockade enhances functionality of peritoneal NK cells with altered expression of DNAM-1/TIGIT/CD96 checkpoint molecules in ovarian cancer

OncoImmunology, 2020
Advanced ovarian cancer (OC) patients have a poor 5-year survival of only 28%, emphasizing the medical need for improved therapies. Adjuvant immunotherapy could be an attractive approach since OC is an immunogenic disease and the presence of tumor ...
Ralph Ja Maas, Janneke S Hoogstad-van Evert, Jolien Mr Van der Meer, Vera Mekers, Somayeh Rezaeifard, Alan J Korman, Paul Kjd de Jonge, Jeannette Cany, Rob Woestenenk, Nicolaas Pm Schaap, Leon F Massuger, Joop H Jansen, Willemijn Hobo, Harry Dolstra   +13 more
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Prognostic value of CD155/TIGIT expression in patients with colorectal cancer.

PLoS ONE, 2022
IntroductionThe interaction of CD155 with its ligand, the T cell immunoreceptor with Ig and ITIM domains (TIGIT), is being studied owing to its potential to act as a target in the treatment of various solid tumors. However, the relationship between CD155
Daisuke Murakami, Kenji Matsuda, Hiromitsu Iwamoto, Yasuyuki Mitani, Yuki Mizumoto, Yuki Nakamura, Ibu Matsuzaki, Ryuta Iwamoto, Yuichi Takahashi, Fumiyoshi Kojima, Shin-Ichi Murata, Hiroki Yamaue   +11 more
doaj   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

TIGIT therapy for cancer treatment – TIGITtherapy – ERC

, 2018
Treating tumors with immune-related therapies is one of the most exciting and promising advancements made in the past decade. Cancer immunotherapy drugs have captured nearly 50% of the overall oncology drugs market.
Mandelboim, Ofer, Tsukerman, Pinchas, Jonjić, Stipan, Kučan Brlić, Paola   +3 more
core   +1 more source