Results 61 to 70 of about 26,086 (200)

DataSheet_1_Self-delivery of TIGIT-blocking scFv enhances CAR-T immunotherapy in solid tumors.pdf

, 2023
Chimeric antigen receptor T cell therapy has become an important immunotherapeutic tool for overcoming cancers. However, the efficacy of CAR-T cell therapy in solid tumors is relatively poor due to the complexity of the tumor microenvironment and ...
Zhigang Hu (477325), Feng Ji (525838), Zhengliang Chen (6792494), Jun Li (6494), Jiannan Chen (4216375), Fan Yang (1413), Zhigang Guo (727834), Fan Zhang (46132)   +7 more
core   +1 more source

Combined Blockade of TIGIT and CD39 or A2AR Enhances NK-92 Cell-Mediated Cytotoxicity in AML

, 2021
This study aimed to characterize different natural killer (NK) cell phenotypes on bone marrow and peripheral blood cells from acute myeloid leukemia (AML) patients and healthy donors (HDs).
Yinghui Duan, Carsten Bokemeyer, Stephan Menzel, Friedrich Koch-Nolte, Elisa Seubert, Jasmin Wellbrock, Walter Fiedler, Franziska Brauneck, Julian Schulze zur Wiesch, Tim Magnus   +9 more
core   +1 more source

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

Advanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng, Qinlian Jiao, Jiankang Zhu, Yidan Ren, Xiaoyu Teng, Xin Su, Zigan Li, Yuxuan Cai, Xiaoyan Liu, Yunshan Wang, Guangyong Zhang   +10 more
wiley   +1 more source

Potential effect of tumor-specific Treg-targeted antibodies in the treatment of human cancers: A bioinformatics analysis

OncoImmunology, 2018
One of the mechanisms of tumor rejection in immune-modulatory treatments is antibody-dependent cell-mediated cytotoxicity (ADCC) of regulatory T cells (Tregs) that infiltrate tumors in which cells expressing activating Fcγ receptors (FcγRs) are present ...
Luigi Cari, Giuseppe Nocentini, Graziella Migliorati, Carlo Riccardi   +3 more
doaj   +1 more source

Computer-aided design of PVR mutants with enhanced binding affinity to TIGIT

Cell Communication and Signaling, 2021
Background TIGIT, as a novel immune checkpoint molecule involved in T cell and NK cell anergy, could induce the immune tolerance and escape through binding with its ligand PVR.
Xiaowen Zhou, Jiangfeng Du, Xiuman Zhou, Xiaoshuang Niu, Wanqiong Li, Chunxia Chen, Sifan Lv, Aijun Wu, Shanshan Gou, Yixuan Sun, Wenjie Zhai, Lu Qiu, Yuanming Qi, Wenshan Zhao, Yanfeng Gao   +14 more
doaj   +1 more source

CD86‐Positive Mature Tertiary Lymphoid Structures Are Associated With CD8+ T‐Cell Infiltration and Favorable Clinical Outcomes in Pancreatic Ductal Adenocarcinoma

Annals of Gastroenterological Surgery, EarlyView.
CD86‐positive mature tertiary lymphoid structures were associated with increased intratumoral CD8+ T‐cell infiltration, a higher proportion of Granzyme B‐expressing CD8+ T cells in an exploratory analysis, and favorable clinical outcomes in pancreatic ductal adenocarcinoma.
Takaomi Seki, Kenichiro Araki, Takehiko Yokobori, Hayato Ikota, Norio Kubo, Takamichi Igarashi, Mariko Tsukagoshi, Norihiro Ishii, Yasuo Hosouchi, Hiroshi Saeki, Ken Shirabe   +10 more
wiley   +1 more source

HBZ upregulates TIGIT expression.

, 2016
(A) TIGIT mRNA was increased in CD4+ T cells of HBZ-Tg mice (n = 7) compared with those of non-Tg mice (n = 7). (B) TIGIT expression was enhanced on resting and activated CD4+ T cells from HBZ-Tg mice by flow cytometry (FCM). The representative histogram
Norihiro Takenouchi (73063), Yutaka Suzuki (1379), Kenji Sugata (843736), Masao Matsuoka (230587), Keiko Takemoto (843735), Jun-ichirou Yasunaga (230581), Keiko Yasuma (843734), Yuichi Mitobe (843737), Masanori Nakagawa (105840)   +8 more
core   +1 more source

Blocking TIGIT/CD155 signalling reverses CD8+ T cell exhaustion and enhances the antitumor activity in cervical cancer

Journal of Translational Medicine, 2022
Objective TIGIT/CD155 has attracted widespread attention as a new immune checkpoint and a potential target for cancer immunotherapy. In our study, we evaluated the role of TIGIT/CD155 checkpoints in the progression of cervical cancer.
Lu Liu, Aihong Wang, Xiaoli Liu, Sai Han, Yu Sun, Junhua Zhang, Lingyu Guo, Youzhong Zhang   +7 more
doaj   +1 more source

Autoreactivity Versus Autoimmunity: Characteristics of Autoantigen‐Specific CD4 T Cells in Rheumatoid Arthritis and Health

Arthritis &Rheumatology, EarlyView.
Objective CD4 T cells specific for citrullinated (cit) peptides are key players in rheumatoid arthritis (RA) immunopathogenesis. Characterizing these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next ...
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source

Tiragolumab (Anti-TIGIT) in SCLC: Skyscraper-02, a Towering Inferno

Lung Cancer: Targets and Therapy, 2023
Danielle Brazel,1 Sai-Hong Ignatius Ou,1,2 Misako Nagasaka1– 3 1Department of Medicine, University of California Irvine School of Medicine, Orange, CA, USA; 2Chao Family Comprehensive Cancer Center, Orange, CA, USA; 3St.
Brazel D, Ou SI, Nagasaka M
doaj