Results 171 to 180 of about 7,097 (193)

Pharmacological and structural characterization of vibostolimab, a novel anti-TIGIT blocking antibody for cancer immunotherapy. [PDF]

J Immunother Cancer
Fischmann TO, Malashock D, Ahn E, Wang H, Pradhan K, Grein J, Chakravorty S, Bahmanjah S, Ban D, Chien E, Hsieh M, Mayhood T, Yuan J, Wong JC, Beaumont M, Baker J, McCoy MA, Cai M, Wilson D, Blumenschein W, Williams SMG, Fayadat-Dilman L, Seghezzi W, Keenan T, Han JH.   +24 more
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Expression of DNAM-1 (CD226) on inflammatory monocytes

Expression of DNAM-1 (CD226) on inflammatory monocytes
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CD226 promotes renal fibrosis by regulating macrophage activation and migration

Journal of Leukocyte Biology, 2023
It has been found that CD226 plays an important role in regulating macrophage function, but its expression and function on macrophage during renal fibrogenesis have not been studied. Our data demonstrated that CD226 expression in macrophages was obviously upregulated in the UUO model, while CD226 deficiency attenuated collagen deposition in renal ...
Yun Song, Yazhen Wang, Juan Li, Yuting Shen, Yongli Hou, Zhaoyue Fu, Liang Fang, Boquan Jin, Lihua Chen   +8 more
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Generation of Rat Monoclonal Antibodies Against Murine PTA1/CD226

Hybridoma, 2007
PTA1 (platelet and T cell antigen 1), designated as CD226, is one of the major activating receptors on NK cells. PTA1/CD226 is also broadly expressed on a variety of hematopoietic cells, including Th cells, CTLs, NK T cells, monocytes, DCs, and mast cells, and is involved in multiple immunoregulation.
Donglin, Wang, Xinhai, Zhang, Xiangsheng, Xu, Chaojun, Song, Zhuwei, Xu, Boquan, Jin   +5 more
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Unlocking the significance of CD226 in cancer

Cell Signaling, 2023
Cancer remains a significant global health challenge, with researchers continually striving to unravel the complexities of its development and progression. In recent years, CD226, also known as DNAM-1, has emerged as a key player in cancer biology.
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CD226 deficiency attenuates the homeostasis and suppressive capacity of Tr1 cells

Molecular Immunology, 2021
T regulatory type 1 (Tr1) cells act as a key regulator in maintaining peripheral immune tolerance. Several costimulatory molecules for T cells have been identified in Tr1 cells, but their intrinsic functions are still unclear. Here we showed CD226 was highly expressed in Tr1 cells. CD226-deficient Tr1 cells were defective in proliferation and sensitive
Ning, Wang, Ping, Chen, Yun, Song, Yuting, Shen, Juan, Li, Xinyu, Li, Liang, Fang, Lihua, Chen   +7 more
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CD226 is involved in megakaryocyte activation and early-stage differentiation

Molecular Immunology, 2019
This study was conducted to investigate the effect of CD226 on the differentiation, activation, and polyploidization of megakaryocytes (MKs) and explore the potential mechanism. Dami (megakaryocyte line) cell maturation was induced by phorbol 12-myristate 13-acetate. CD226 was silenced by infection with a CD226-specific shRNA lentiviral vector.
Jinxue, Zhang, Ran, Zhuang, Xuexin, Zhang, Wei, Hu, Kun, Cheng, Dongxu, Jiang, Shen, Shen, Yun, Zhang, Yong, Ding, Yuan, Zhang   +9 more
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Recovery of CD226-TIGIT+FoxP3+ and CD226-TIGIT-FoxP3+ regulatory T cells contributes to clinical remission from active stage in ulcerative colitis patients

Immunology Letters, 2020
Ulcerative colitis (UC) is a chronic inflammatory immune-related disease. Imbalance between pathogenic cells and immunosuppressive cells is associated with disease activity of UC. Regulatory T cells (Tregs) are critical for this immune homeostasis. However, the clinical significance of CD226 and TIGIT expressions on FoxP3+Tregs in UC remains unclear ...
Yan, Long, Chengbin, Wang, Changsheng, Xia, Xiaoxu, Li, Chunhong, Fan, Xiaotao, Zhao, Chen, Liu   +6 more
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The CD226 gene in susceptibility of type 1 diabetes

Tissue Antigens, 2009
AbstractThe rs763361 single nucleotide polymorphism (SNP) within the CD226 gene has recently been reported as a novel susceptible locus for type 1 diabetes. The CD226 gene is implicated in the regulation of a number of cells involved in immune mechanisms leading to β‐cell destruction in type 1 diabetes.
K, Douroudis, V, Nemvalts, T, Rajasalu, K, Kisand, R, Uibo   +4 more
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The CD226 Gly307Ser gene polymorphism is associated with severity of psoriasis

Journal of Dermatological Science, 2010
Psoriasis is a chronic inflammatory T-cell mediated disease of the skin with a complex pathogenesis involving both genetic and environmental factors [1]. Several regions in the genome including the major histocompatibility complex (MHC) [2], [3] have been reported to confer susceptibility to psoriasis risk; however, the genetic background of psoriasis ...
Douroudis, K., Kingo, K., Silm, H., Reimann, E., Traks, T., Vasar, E., Kõks, S.   +6 more
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