Results 1 to 10 of about 8,868 (210)

Targeting CD276 with Adapter-CAR T-cells provides a novel therapeutic strategy in small cell lung cancer and prevents CD276-dependent fratricide [PDF]

Journal of Hematology & Oncology
Background Survival rates in Small Cell Lung Cancer (SCLC) remain dismal, posing a huge medical need for novel therapies. T-cells, engineered to express chimeric antigen receptors (CAR-T) have demonstrated clinical activity against a variety of ...
Beate Kristmann, Niels Werchau, Lakshmi Suresh, Elisabeth L. Pezzuto, Sophia Scheuermann, Simon Krost, Karin Schilbach, Moustafa Moustafa-Oglou, Anna-Sophia Mast, Miriam Droste, André Felsberger, Lukas Kiefer, Pierre Abramowski, Lars Zender, Joerg Mittelstaet, Christian M. Seitz   +15 more
doaj   +7 more sources

B7-H3/CD276: Novel Immune Checkpoint and Jack of All Trades [PDF]

ImmunoTargets and Therapy
Brigid Larkin,1,* Daisuke Nishizaki,1,* Hirotaka Miyashita,2 Suzanna Lee,1 Mina Nikanjam,1 Ramez N Eskander,3 Taylor J Jensen,4 Sarabjot Pabla,4 Jeffrey M Conroy,4 Paul DePietro,4 Jason K Sicklick,5 Razelle Kurzrock,6,7,* Shumei ...
Larkin B, Nishizaki D, Miyashita H, Lee S, Nikanjam M, Eskander RN, Jensen TJ, Pabla S, Conroy JM, DePietro P, Sicklick JK, Kurzrock R, Kato S   +12 more
doaj   +5 more sources

An EBNA1-YAP signaling axis drives immune escape through CD276 in EBV-associated gastric cancer [PDF]

Cell Death and Disease
Clinical efficacy of anti-PD1 immunotherapy often yields low response rates in Epstein-Barr virus-associated gastric cancer (EBVaGC). To gain insights into immune escape mechanisms and discover critical molecules in anti-tumor immunity, we performed an ...
Binhao Huang, Mengqi Liu, Yantao Duan, Jing Guo, Zixian Wang, Yi Dou, Mengyun Wang, Omar Abuhaidar, Henian Sun, Leung Siu Kee, Yu Wang, Gong-Hong Wei, Dazhi Xu   +12 more
doaj   +3 more sources

Blockade of CD155 and CD276 by Monoclonal Antibodies Fosters Immune Tolerance and Promotes Stable Engraftment of iPSC-Derived Islets in Allogeneic Humanized Mice. [PDF]

Transpl Int
Induced pluripotent stem cell (iPSC)-derived pancreatic islets represent a promising therapeutic approach for restoring insulin independence in type 1 diabetes (T1D).
Siracusano G, Deambrogio F, Sordi V, Malnati M, Piemonti L, Chimienti R.   +5 more
europepmc   +4 more sources

Mechanisms for fibrate lipid-lowering drugs in enhancing bladder cancer immunotherapy by inhibiting CD276 expression [PDF]

BMC Cancer
Objective This study aimed to investigate the growth-inhibitory effects of fibrate lipid-lowering drugs on bladder cancer cells and their underlying mechanisms, with a focus on exploring how fenofibrate (FNF) exerts antitumor effects by regulating ...
Cheng Li, Jiahao Liu, Long Wang, Wei Xiong   +3 more
doaj   +3 more sources

UBE2T/CDC42/CD276 signaling axis mediates brain metastasis of triple-negative breast cancer via lysosomal autophagy [PDF]

Journal for ImmunoTherapy of Cancer
Background Advanced triple-negative breast cancer (TNBC) is prone to brain metastasis (BrM). The precise molecular mechanism responsible for this phenomenon has not yet been completely established, so it is vital to comprehend the molecular mechanism ...
Lin Li, Rong Fu, Yan Chen, Jin Yao, Xiaobing Jiang, Tao Liang, Jun jun Li, Qian zhi Chen, Liang Liang Shi, Ming Xing Xie, Xin Wei Qiao, Qi Hong Cheng, Min Jie Wang   +12 more
doaj   +3 more sources

Fc-optimized CD276 antibody enhances NK cell activation against non-small cell lung cancer [PDF]

Frontiers in Immunology
Non-small cell lung cancer (NSCLC) is one of the most common and lethal cancers worldwide, with a poor prognosis for many patients, especially in advanced stages. The development of immune checkpoint inhibitors (ICIs) has transformed treatment strategies
Sylwia A. Stefańczyk, Sylwia A. Stefańczyk, Xenija Kaiser, Xenija Kaiser, Ilona Hagelstein, Ilona Hagelstein, Samuel Holzmayer, Samuel Holzmayer, Latifa Zekri, Latifa Zekri, Susanne Jung, Susanne Jung, Susanne Jung, Melanie Märklin, Melanie Märklin   +14 more
doaj   +3 more sources

The MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276 [PDF]

Cellular & Molecular Biology Letters, 2020
Background The links between the p53/MDM2 pathway and the expression of pro-oncogenic immune inhibitory receptors in tumor cells are undefined. In this report, we evaluate whether there is p53 and/or MDM2 dependence in the expression of two key immune ...
Ruidong Li, Pavlina Zatloukalova, Petr Muller, Maria Gil-Mir, Sachin Kote, Simon Wilkinson, Alain J. Kemp, Lenka Hernychova, Yaxin Wang, Kathryn L. Ball, Kaixiong Tao, Ted Hupp, Borivoj Vojtesek   +12 more
doaj   +3 more sources

Identification and validation of cuproptosis-related immune checkpoint expression for glioblastoma [PDF]

BMC Cancer
Objective Investigating the expression levels of immune checkpoint genes CD276, CD40, TNFSF14, and TNFSF9 in glioblastoma multiforme patients about copper death and patient prognosis.
Jinhui Huang, Shoufang Tong, Jin Liu, Shushan Hua, Jie Zhang, Rajneesh Mungur, Shuai Liu, Jiugeng Feng, Bin Tang, Jianping Zeng   +9 more
doaj   +2 more sources

m276-SL-PBD eradicates tumors and instigates long-lasting tumor-free survival in Merkel cell carcinoma preclinical models [PDF]

iScience
Summary: Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine carcinoma, and immune checkpoint inhibitors (ICIs) are the only approved therapy; nonetheless, resistance is notable and there is a critical need for novel effective therapies ...
Mikaela D. Kunika, Aarthi Kannan, Graham J. Velasco, Yang Feng, Steven Seaman, Bhaba K. Das, Dillon Pham, Nils Lambrecht, Haibo Zhao, Brad St. Croix, Ling Gao   +10 more
doaj   +2 more sources