Results 91 to 100 of about 8,868 (210)

Phase 1 study of intraventricular 131I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies

Journal of Hematology & Oncology, 2022
Abstract Background The prognosis for metastatic and recurrent tumors of the central nervous system (CNS) remains dismal, and the need for newer therapeutic targets and modalities is critical. The cell surface glycoprotein B7H3 is expressed on a range of solid tumors with a restricted expression on normal tissues.
Kim Kramer, Neeta Pandit-Taskar, Brian H. Kushner, Pat Zanzonico, John L. Humm, Ursula Tomlinson, Maria Donzelli, Suzanne L. Wolden, Sophia Haque, Ira Dunkel, Mark M. Souweidane, Jeffrey P. Greenfield, Satish Tickoo, Jason S. Lewis, Serge K. Lyashchenko, Jorge A. Carrasquillo, Bae Chu, Christopher Horan, Steven M. Larson, Nai-Kong V. Cheung, Shakeel Modak   +20 more
openaire   +3 more sources

The prognostic role of intragenic copy number breakpoints and identification of novel fusion genes in paediatric high grade glioma [PDF]

, 2014
BACKGROUND: Paediatric high grade glioma (pHGG) is a distinct biological entity to histologically similar tumours arising in older adults, and has differing copy number profiles and driver genetic alterations.
A Fusco, AB Olshen, AJ Iafrate, B Filipek-Gorniok, BS Paugh, BS Paugh, C Jones, D Lam, D Singh, D Sturm, DA Bax, DA Bax, DA Solomon, DW Parsons, F Cesca, FV Fuller-Pace, GM Findlay, J Cools, J Schwartzentruber, JF Gainor, JH Wright, JP Adams, JR Bertino, K Holmborn, M Soda, P Liu, R Beroukhim, R McLendon, R Wiedemeyer, S Veeriah, S Zheng, SA Tomlins, T Ozawa, V Frattini, VE Neubrand, W Wu   +35 more
core   +1 more source

Immune Checkpoints in Recurrent Pregnancy Loss: New Insights into a Detrimental and Elusive Disorder [PDF]

, 2023
Recurrent pregnancy loss (RPL) refers to two or more miscarriages before 20 weeks gestation. Its prevalence is 1–2%; its pathogenesis remains unexplained in more than 50% of cases, in which the cause is thought to be abnormal immune activity during
Benedetto, Chiara, Canuto, Emilie M, Cosma, Stefano, Goia, Margherita, Gullo, Eugenio, Marozio, Luca, Moretti, Laura, Nuzzo, Anna Maria, Revelli, Alberto, Rolfo, Alessandro, Tancredi, Annalisa   +10 more
core   +1 more source

Protein design and RNA design: Perspectives

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley   +1 more source

Tissue‐Specific Extracellular Vesicles Enriched From Circulation: Exploring the Liquid Biopsy Perspective

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT Extracellular vesicles (EVs) released from tissues can be found in human biofluids. EVs reflect the phenotypic state of their cell of origin, carrying informative molecular biomarkers within and between tissues, and represent a promising target for liquid biopsy.
Biancamaria Pierri, Erez Eitan, Kenneth W. Witwer, Diane B. Re, Andrea A. Baccarelli, Haotian Wu   +5 more
wiley   +1 more source

Novel Functional eQTL-SNPs Associated With Susceptibility to Mycoplasma pneumoniae Pneumonia in Children

Frontiers in Public Health, 2022
BackgroundThe functional causal single-nucleotide polymorphisms (SNPs) associated with susceptibility to Mycoplasma pneumoniae Pneumonia (MPP) have scarcely been identified.
Yang Dong, Yanmin Gao, Cheng Luo, Nengshun Wu, Zhounan Cheng, Anni Qiu, Yan Zhou, Wendi Zhang, Minjie Chu, Qing Chang   +9 more
doaj   +1 more source

Comparison of the transcriptional profiles of melanocytes from dark and light skinned individuals under basal conditions and following ultraviolet-b irradiation [PDF]

, 2015
We analysed the whole-genome transcriptional profile of 6 cell lines of dark melanocytes (DM) and 6 of light melanocytes (LM) at basal conditions and after ultraviolet-B (UVB) radiation at different time points to investigate the mechanisms by which ...
Alonso, Santos, Boyano, Dolores, de la Rúa, Concepción, García de Galdeano, Alicia, García, Oscar, Gardeazábal, Jesús, Izagirre, Neskuts, López, Saioa, Martinez-Cadenas, Conrado, Smith-Zubiaga, I.   +9 more
core   +3 more sources

Development of a Novel Extracellular Vesicle‐Based Biomarker Approach for Pediatric High‐Grade Glioma

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT Pediatric high‐grade gliomas (pHGGs) account for 20% of childhood brain tumours and are associated with poor survival. Currently, pHGG detection relies on MRI, a costly and time‐consuming procedure. Extracellular vesicles (EVs) carry molecular markers indicative of their cellular origin and can be isolated from various biofluids, offering an ...
Adriana Fernandez Garcia, Poorvi Iyer, Pablo Ashi, Ibukunoluwa Tella, Vennela Sangaraboina, Dhruv Bhagat, Chelva Janarthanam, Alejandra Bargues‐Carot, Anumantha G. Kanthasamy, Thomas Spoerer, Morgane E. Golan, Steven L. Stice, Kosuke Funato   +12 more
wiley   +1 more source

RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish [PDF]

, 2012
BACKGROUND: Zebrafish (Danio rerio) is a prominent vertebrate model of human development and pathogenic disease and has recently been utilized to study teleost immune responses to infectious agents threatening the aquaculture industry.
Dahai Yang, Haizhen Wu, Jingfan Xiao, Minjun Yang, Qin Liu, Qiyao Wang, Yuanxing Zhang   +6 more
core   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source