Results 101 to 110 of about 8,868 (210)

IMMU-11. Evaluation of CAR-T cells targeting CD276 in medulloblastoma

Neuro-Oncology, 2022
Abstract Brain tumors are the most frequent category of solid tumors in children and have the highest mortality rate among all pediatric cancers. Although diagnosis and treatment have improved prognosis over the past decades for some childhood brain tumors, others remain lethal and current treatments are highly toxic to the developing ...
Patricia Benites Goncalves da Silva, Laura Sieber, Norman Mack, Daniel Atar, Lena M Kutscher, Patrick Schlegel, Martin Ebinger, Daisuke Kawauchi, Christian Seitz, Stefan M Pfister   +9 more
openaire   +1 more source

Increased concentrations of soluble B7-H3 and interleukin 36 in bronchoalveolar lavage fluid of Children with Mycoplasma pneumoniae pneumonia [PDF]

, 2016
Supporting data.
Canhong Zhu, Guangbo Zhang, Huiming Sun, Wei Ji, Wujun Jiang, Xin Zhao, Xinxing Zhang, Yongdong Yan, Yuqing Wang, Zhengrong Chen   +9 more
core   +2 more sources

Prognostic Impact of DPP4 Inhibitors on Systemic Drug Therapy for Advanced Kidney Cancer Patients

Cancer Science, Volume 117, Issue 2, Page 468-475, February 2026.
Treatment with DPP4 inhibitors was identified as a favorable prognostic factor in patients with advanced RCC. A more substantial degree of tumor shrinkage was observed in the subgroup of patients who received tyrosine kinase inhibitors or immune checkpoint inhibitors as first‐line therapy.
Shuhei Kamada, Sachi Kitayama, Ryosuke Yamase, Kazuhiro Ikeda, Wataru Sato, Tomokazu Sazuka, Hideki Takeshita, Shinichi Sakamoto, Akihiro Yano, Kuniko Horie, Tomohiko Ichikawa, Satoru Kawakami, Satoshi Inoue   +12 more
wiley   +1 more source

Bioinformatic Analysis and Clinical Case Studies Identify CD276 as a Promising Diagnostic Biomarker for Clear Cell Renal Cell Carcinoma

Cancer Control
Objective This study aimed to explore the relationship between CD276 and clear cell renal carcinoma (ccRCC) and assess the diagnostic value of CD276 in ccRCC.
Zhiyu Zhang M.D., Jianhao Xu M.D., Zhen Song M.D., Jianglei Zhang Ph.D., Yuxin Lin Ph.D., Jun Ouyang Ph.D.   +5 more
doaj   +1 more source

Alterations of immune response of non-small lung cancer with azacytidine [PDF]

, 2013
Innovative therapies are needed for advanced Non-Small Cell Lung Cancer (NSCLC). We have undertaken a genomics based, hypothesis driving, approach to query an emerging potential that epigenetic therapy may sensitize to immune checkpoint therapy targeting
Baylin, Stephen B, Brahmer, Julie R, Brock, Malcolm V, Carvajal, Richard D, De Meyer, Tim, Du, Zhengzong, Easton, Keith, Easwaran, Hariharan, Jones, Peter A, Juergens, Rosalyn A, Koch, Alexander, Laird, Peter W, Mohammad, Helai P, Pardoll, Drew, Parsana, Princy, Rodgers, Kristen, Rudin, Charles M, Taube, Janis M, Topalian, Suzanne L, Tsai, Salina, Tykodi, Scott S, Van Criekinge, Wim, Vendetti, Frank, Wang, Wei, Weisenberger, Daniel J, Wrangle, John, Yen, Ray-Whay, Zahnow, Cynthia A   +27 more
core   +1 more source

Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab [PDF]

, 2015
Multiplexed biomarker analysis showing modulation of Th1/Th2 cytokines, chemokines and growth factors post varlilumab ...
Biwei Zhao, Henry C. Marsh, Karuna Sundarapandiyan, Max Bylesjo, Tibor Keler, Venky Ramakrishna   +5 more
core   +3 more sources

Multi‐Omics Integration for Advancing Glioma Precision Medicine

Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 4-13, January 2026.
ABSTRACT Gliomas are among the most malignant and aggressive tumors of the central nervous system, characterized by the absence of early diagnostic markers, poor prognosis, and a lack of effective treatments. Advances in high‐throughput technologies have facilitated a refined molecular classification of gliomas, incorporating genetic features. However,
Maria Guarnaccia, Valentina La Cognata, Giulia Gentile, Giovanna Morello, Sebastiano Cavallaro   +4 more
wiley   +1 more source

Mass spectrometry analysis of adipose-derived stem cells reveals a significant effect of hypoxia on pathways regulating extracellular matrix [PDF]

, 2016
Over-represented biological processes by gene ontology analysis of proteins identified in the secretome fraction.
Allan Stensballe, Cristian Pablo Pennisi, Jeppe Emmersen, Simone Riis, Svend Birkelund, Trine Fink, Vladimir Zachar   +6 more
core   +5 more sources

MCUB Inhibits PRKN‐Dependent Mitophagic Degradation of PD‐L1 to Promote Immune Evasion in Bladder Cancer

Advanced Science, Volume 13, Issue 5, 27 January 2026.
In bladder cancer, the overexpression of MCUB not only reduces mitochondrial calcium influx but also facilitates its binding to PRKN at Arg51, both mechanisms contribute to the impairment of PRKN‐mediated mitophagy. Consequently, the degradation of PD‐L1 is suppressed, leading to its stable expression on the tumor cell surface.
Yuan Huang, Chen Chen, Mingqiang Su, Dongqing Li, Jinge Zhang, Kuangye Long, Wenbin Nie, Shu Wei, Wei Chen, Haiyong Chen, Zhangfeng Zhong, Lina Hou, Wanlong Tan, Fei Li   +13 more
wiley   +1 more source

CAR T-cells targeting FGFR4 and CD276 simultaneously show potent antitumor effect against childhood rhabdomyosarcoma

Nature Communications
Chimeric antigen receptor (CAR) T-cells targeting Fibroblast Growth Factor Receptor 4 (FGFR4), a highly expressed surface tyrosine receptor in rhabdomyosarcoma (RMS), are already in the clinical phase of development, but tumour heterogeneity and ...
Meijie Tian, Jun S. Wei, A. Cheuk, D. Milewski, Zhongmei Zhang, Y. Kim, Hsien-Chao Chou, Can Liu, Sherif Badr, Eleanor G Pope, Abdelrahman Rahmy, Jerry T. Wu, Michael C. Kelly, Xinyu Wen, Javed Khan   +14 more
semanticscholar   +1 more source