Results 111 to 120 of about 8,868 (210)

Essential role of HDAC6 in the regulation of PD-L1 in melanoma [PDF]

, 2016
Indexación: Web of Science; Scopus.Histone deacetylases (HDACs), originally described as histone modifiers, have more recently been deMonstrated to target a variety of other proteins unrelated to the chromatin environment.
Cheng, F., Deng, S., Knox, T., Kozikowski, A., Lee, C., Lienlaf, M., Montecino, M., Pabon, M., Perez-Villarroel, P., Pinilla-Ibarz, J., Powers, J., Sahakian, E., Sarnaik, A., Seto, E., Smalley, K.S.M., Sotomayor, E.M., Villagra, A., Weber, J., Woan, K.V.   +18 more
core   +1 more source

Drivers of clinical resistance to venetoclax and hypomethylating agents in acute myeloid leukemia and strategies for improving efficacy

HemaSphere, Volume 10, Issue 1, January 2026.
ABSTRACT The B‐cell lymphoma 2 (BCL‐2) inhibitor venetoclax (VEN) in combination with hypomethylating agents (HMAs) has improved treatment outcomes for acute myeloid leukemia (AML) patients unfit for intensive chemotherapy and is increasingly used in the relapsed/refractory setting. However, primary resistance remains a significant challenge, affecting
Ida Vänttinen, Joseph Saad, Tanja Ruokoranta, Sari Kytölä, Guangrong Qin, Bahar Tercan, Pia Ettala, Anu Partanen, Marja Pyörälä, Johanna Rimpiläinen, Timo Siitonen, Mikko Manninen, Peter J. M. Valk, Gerwin Huls, Vésteinn Thorsson, Caroline A. Heckman, Mika Kontro, Heikki Kuusanmäki   +17 more
wiley   +1 more source

CD276 as a promising diagnostic and prognostic biomarker for bladder cancer through bioinformatics and clinical research

Frontiers in Oncology
ObjectiveTo assess CD276 expression and explore its relationship with the clinicopathological characteristics and prognosis of patients with bladder cancer.MethodsIn total, RNA-sequencing data and clinical profiles of 436 bladder cancer cases from The ...
Qi Zhou, Jianhao Xu, Xuelei Chen, Jun Ouyang, Caiping Mao, Zhiyu Zhang   +5 more
doaj   +1 more source

Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease [PDF]

, 2016
This is an open-access article distributed under the terms of the Creative Commons Attribution License.Despite evidence about the implication of the bone marrow (BM) stromal microenvironment in multiple myeloma (MM) cell growth and survival, little is ...
Blanco, Juan F., De Las Rivas, Javier, Díaz-Rodríguez, Elena, Garayoa, Mercedes, García-Gómez, Antonio, Martín-Sánchez, Montserrat, Montero, Juan Carlos, Ocio, Enrique M., Pandiella, Atanasio, San Miguel, Jesús F., Sánchez-Guijo, Fermín M.   +10 more
core   +1 more source

Systematic Pathway Screening via Integrated Machine Learning Identifies FOXO‐Mediated Transcription Signature for Robust Immunotherapy Response Prediction in Non–Small Cell Lung Cancer

Human Mutation, Volume 2026, Issue 1, 2026.
Background Non–small cell lung cancer (NSCLC), accounting for 80% of lung cancer cases, remains a leading cause of cancer‐related mortality globally. While immune checkpoint inhibitors (ICIs) have improved outcomes, their efficacy is limited to a subset of patients, necessitating robust biomarkers for personalized immunotherapy response prediction ...
Shuqi Wu, Chenxi Deng, Chaofan Fan, Qiheng Liang, Lingxuan Zhu, Weiming Mou, Hongsen Huang, Keren Wu, Yizhang Li, Gengwen Deng, Liling Xu, Jiarui Xie, Chenglin Hong, Yuhang Deng, Xingjian Li, Changda Wu, Tao Yang, Peng Luo, Hank Z. H. Wong, Aimin Jiang, Anqi Lin, Xin Chen, Minghua Ren   +22 more
wiley   +1 more source

Proteomic Applications in the Study of Human Mesenchymal Stem Cells [PDF]

, 2014
Mesenchymal stem cells (MSCs) are undifferentiated cells with an unlimited capacity for self-renewal and able to differentiate towards specific lineages under appropriate conditions.
Arufe, M.C., Blanco García, Francisco J, Fafián Labora, Juan Antonio, Fernández-Pernas, Pablo, Mateos, Jesús   +4 more
core   +3 more sources

IER3 Promotes Malignant Progression of Colorectal Cancer Through the NF‐κB Pathway

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality worldwide, primarily due to metastatic progression and an immunosuppressive tumor immune microenvironment (TIME). The stress‐responsive gene IER3 is found to be dysregulated in multiple cancers.
Zhigang Wei, Yinyi Luo, Yupeng Zhang, Qingxing Huang, Jianhang Shao, Yingying Zhang, Yuqi Zhang, Zhimin Wang, Chaojie Liang, Zhiyong Lai, Yongping Cui, Pengpeng Zhang   +11 more
wiley   +1 more source

Cardiotoxicity of immune checkpoint inhibitors [PDF]

, 2017
Cardiac toxicity after conventional antineoplastic drugs (eg, anthracyclines) has historically been a relevant issue. In addition, targeted therapies and biological molecules can also induce cardiotoxicity.
Allison, Atkins, Azuma, Azuma, Baban, Badros, Bellmunt, Bloom, Borghaei, Boussiotis, Boutros, Brahmer, Brahmer, Bretscher, Brunet, Buchbinder, Cardinale, Cardinale, Chen, Chen, Chen, Cooper, Corsello, Costa, Ding, Dong, Dong, Douglas, Dyck, Eigentler, Fehrenbacher, Francisco, Freeman, Freeman, Gagliani, Gangadhar, Garon, Gay, Geisler, Gibson, Goodman, Gordon, Grabie, Hamanishi, Hamid, Hamo, Han, Hathcock, Heinzerling, Herbst, Herbst, Hodi, Hofmann, Huang, Hurst, Jain, Johnson, Johnson, Johnston, Keir, Khan, Koelzer, Lacouture, Larkin, Lasaro, Latchman, Le Mercier, Le Mercier, Leach, Lesokhin, Lines, Linsley, Linsley, Lucas, Läubli, Mahoney, Martin, Matsuzaki, Menzies, Michot, Mohme, Moslehi, Moynihan, Naidoo, Nayak, Nghiem, Nguyen, Ni, Nishimura, Nishimura, Okamura, Okazaki, Okazaki, Pardoll, Peggs, Pitt, Postow, Powles, Prashanth, Ribas, Rittmeyer, Rizvi, Robert, Robert, Roth, Sakuishi, Semper, Sharma, Sharma, Sheppard, Sivan, Smyth, Spain, Stanietsky, Suter, Tadokoro, Tadokoro, Tarrio, Tivol, Tocchetti, Tocchetti, Topalian, Topalian, Tumeh, Voskens, Vétizou, Wang, Wang, Watanabe, Waterhouse, Weber, Westin, Wing, Wolchok, Woo, Yan, Yeh, Yokosuka, Yu, Yun, Zitvogel   +140 more
core   +1 more source

Immunoregulatory Roles of Tumor‐Originated Pericytes Identified by Single‐Cell Analysis in Glioblastoma

Advanced Science, Volume 12, Issue 47, December 18, 2025.
The origin and functional heterogeneity of pericytes in glioblastoma (GBM) remain unclear. This study identifies tumor‐originated pericytes (T‐PCs) and normal‐originated pericytes as two distinctive populations in human GBM using single‐cell RNA‐sequencing.
Cuiying Chu, Fangzhen Li, Zhiwen Zhang, Qiuhong Zhu, Hong Yan, Mengdan Cheng, Huipeng Wang, Lei Cheng, Zhe Zhang, Xingjiang Yu, Jianghong Man, Wei Wang, Dongxue Li, Xiu‐wu Bian, Hai‐bo Wu, Aili Zhang, Wenchao Zhou   +16 more
wiley   +1 more source

RETRACTED ARTICLE: ArticleNoteCD276 enhances sunitinib resistance in clear cell renal cell carcinoma by promoting DNA damage repair and activation of FAK-MAPK signaling pathway

BMC Cancer
Objective This study aimed to explore the effect of CD276 expression on the sunitinib sensitivity of clear cell renal cell carcinoma (ccRCC) cell and animal models and the potential mechanisms involved. Methods CD276 expression levels of ccRCC and normal
Zhi-yu Zhang, Jian-hao Xu, Jiang-lei Zhang, Yu-xin Lin, Jun Ou-Yang   +4 more
doaj   +1 more source