Results 181 to 190 of about 8,868 (210)

Immune checkpoints regulate acute myeloid leukemia stem cells. [PDF]

Leukemia
Reinhardt C, Ochsenbein AF.
europepmc   +1 more source

Integration of Transcriptome Profiling and Single-Cell Sequencing Analysis to Establish a CD8+ T Cell-Related Prognostic Model for Patients With NSCLC: From Assessment to Therapy. [PDF]

Cancer Med
Jiang YY, Yu MM, Cui X, Li X, Li BB, Zhang JT, Xu F.   +6 more
europepmc   +1 more source

Actionable heterogeneity of hepatocellular carcinoma therapy-induced senescence. [PDF]

Cancer Immunol Immunother
Engels P, Szolek A, Hörner S, Syrigos GV, Hebbel K, Schmidtke M, Zhou M, Mateo-Tortola M, Schönfeld C, Stefanczyk SA, Wolter K, Babaei S, Schindler M, Claassen M, Dauch D, Zender L, Tapía-Abellán A, Weber ANR.   +17 more
europepmc   +1 more source

Immune regulatory genes impact the hot/cold tumor microenvironment, affecting cancer treatment and patient outcomes. [PDF]

Front Immunol
Sang M, Ge J, Ge J, Tang G, Wang Q, Wu J, Mao L, Ding X, Zhou X.   +8 more
europepmc   +1 more source

c-JUN enhances CRISPR knockin anti-B7-H3 CAR T cell function in small cell lung cancer and thoracic SMARCA4-deficient undifferentiated tumors. [PDF]

Cell Rep Med
Balke-Want H, Keerthi V, Del Carmen Arenas M, Chen Y, Malipatlolla M, Klysz DD, Xu P, Ho K, Asano K, Stahl D, Huang J, Retherford A, Patel S, Fowler C, Maas L, Gkitsas-Long N, Jiang Q, Liu X, Ullrich R, George J, Heitzeneder S, Tunuguntla R, Sage J, Sotillo E, Mackall CL, Feldman SA.   +25 more
europepmc   +1 more source

Preliminary screening of urinary host protein biomarkers for Schistosomiasis haematobium: A proteome profiling study identifying candidate diagnostic targets in school-aged children. [PDF]

PLoS Negl Trop Dis
Liu Y, Juma S, Xue Q, He M, Ali SM, Khamis KS, Suleiman MM, Hamad MS, Khamis MA, Zhao H, Dong X, Yang K, Huang Y.   +12 more
europepmc   +1 more source

A library of colorectal cancer immunogenic glycopeptides: A step towards novel theragnostics applications [PDF]

Eliana Janine de Paiva Soares
core  

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CD276 (B7-H3) Is an Immunotherapeutic Target in Acute Myeloid Leukemia with Preclinical Efficacy of Vobramitamab Duocarmazine, an Investigational CD276 Antibody-Drug Conjugate

Blood, 2023
CD276 (B7-H3) is an immune checkpoint inhibitor expressed in a majority of solid tumors and hematologic malignancies, however it has not been well-described in acute myeloid leukemia (AML). A variety of immunotherapies targeting CD276 including CAR T cells and antibody-drug conjugates (ADCs) are being explored in solid tumors, however ...
Danielle C Kirkey, Melia Blankenfeld, Tiffany Hylkema, Deryk Loo, Ashley Ward, Leila Robinson, Jack H Peplinski, Logan K Wallace, Laura Pardo, Andrew J. Menssen, Rhonda E Ries, Soheil Meshinchi   +11 more
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CAR T cells recognizing CD276 and Dual-CAR T cells against CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models

2023
AbstractBackgroundRhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood, whose prognosis is still poor especially for metastatic, high-grade, and relapsed RMS. New treatments are urgently needed, especially systemic therapies. Chimeric Antigen Receptor T cells (CAR Ts) are very effective against hematological malignancies, but ...
Andrea Timpanaro, Caroline Piccand, Dzhangar Dzhumashev, Stenija Anton-Joseph, Andrea Robbi, Janine Moser, Jochen Rössler, Michele Bernasconi   +7 more
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CD276-positive circulating endothelial cells in advanced colorectal cancer.

Journal of Clinical Oncology, 2019
572 Background: The value of circulating endothelial cells (CECs) as predictive biomarker in metastatic colorectal cancer (mCRC) may be improved by using tumor-derived CECs. CD276 can discriminate between tumor derived and normal CECs. We evaluated whether CD276+CEC is a clinically relevant biomarker with 100% sensitivity to predict response to first
Elske C. Gootjes, Jaco Kraan, Tineke Buffart, Cornelis Verhoef, Henk M.W. Verheul, Stefan Sleijfer   +5 more
openaire   +1 more source