Results 11 to 20 of about 8,868 (210)

PRMT5-Mediated ALKBH5 Methylation Promotes Colorectal Cancer Immune Evasion via Increasing CD276 Expression [PDF]

Research
Numerous diseases have been connected to protein arginine methylations mediated by protein arginine methyltransferase 5 (PRMT5). Clinical investigations of the PRMT5-specific inhibitor GSK3326595 are currently being conducted, and the results are ...
Sen Meng, Hao Liu, Jiayu Xu, Chuyin Deng, Xingyou Qian, Sufang Chu, Wei-Guo Zhu, Jiuling Zhu, Hongmei Yong, Zhongwei Li, Jin Bai   +10 more
doaj   +3 more sources

CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer

Nature Communications
Interplay between innate and adaptive immune cells is important for the antitumor immune response. However, the tumor microenvironment may turn immune suppressive, and tumor associated macrophages are playing a role in this transition. Here, we show that
Maosheng Cheng, Shuang Chen, Kang Li, Ganping Wang, Gan Xiong, Rongsong Ling, Caihua Zhang, Zhihui Zhang, Hui Han, Zhi Chen, Xiaochen Wang, Yu Liang, Guoli Tian, Ruoxing Zhou, Yan Zhu, Jieyi Ma, Jiahong Liu, Shuibin Lin, Hao Xu, Demeng Chen, Yang Li, Liang Peng   +21 more
doaj   +4 more sources

The Role of CD276 in Cancers [PDF]

Frontiers in Oncology, 2021
ObjectiveAberrant expression of the immune checkpoint molecule, CD276, also known as B7-H3, is associated with tumorigenesis. In this review, we aim to comprehensively describe the role of CD276 in malignancies and its potential therapeutic effect.Data ...
Shengzhuo Liu, Shengzhuo Liu, Jiayu Liang, Zhihong Liu, Chi Zhang, Yang Wang, Alice Helen Watson, Chuan Zhou, Fan Zhang, Kan Wu, Fuxun Zhang, Yiping Lu, Xianding Wang   +12 more
doaj   +3 more sources

Expression patterns of the immune checkpoint ligand CD276 in urothelial carcinoma [PDF]

BMC Urology, 2021
Background CD276 is an immune checkpoint molecule. Elevated CD276 expression by urothelial carcinoma is associated with poor prognosis, but little is known about its expression across different tumor stages.
Wilhelm K. Aicher, M. Korn, L. Reitnauer, F. B. Maurer, J. Hennenlotter, P. C. Black, T. Todenhofer, J. Bedke, A. Stenzl   +8 more
doaj   +4 more sources

Targeting CD276 for T cell-based immunotherapy of breast cancer

Journal of Translational Medicine
Background Breast cancer (BC) is the most common malignancy in women. Immunotherapy has revolutionized treatment options in many malignancies, and the introduction of immune checkpoint inhibition yielded beneficial results also in BC.
Ilona Hagelstein, Laura Wessling, Alexander Rochwarger, Latifa Zekri, Boris Klimovich, Christian M. Tegeler, Gundram Jung, Christian M. Schürch, Helmut R. Salih, Martina S. Lutz   +9 more
doaj   +5 more sources

New frontiers in immune checkpoint B7-H3 (CD276) research and drug development

Molecular Cancer, 2023
B7-H3 (CD276), a member of the B7 family of proteins, is a key player in cancer progression. This immune checkpoint molecule is selectively expressed in both tumor cells and immune cells within the tumor microenvironment.
A. Getu, Abiye Tigabu, M. Zhou, Jianrong Lu, Ø. Fodstad, Ming Tan   +5 more
semanticscholar   +4 more sources

Codelivery of apigenin, FdUMP and CD276 antibody synergistic inhibit colorectal cancer by ferroptosis-apoptosis-pyroptosis and CD276 blockade

Asian Journal of Pharmaceutical Sciences
Mitochondria provides adenosine triphosphate for multiple vital movements to ensure tumor cell proliferation. Compared to the broadly used method of inducing DNA replication arrest to kill cancer, inducing mitochondria damage to cause energy shortage is quite promising as it can inhibit tumor cell bioactivities, increase intracellular accumulation of ...
Weiran Cao, Xue Zhang, Jiaxuan Chen, Lu Sun, Huining He, Fei Yu   +5 more
semanticscholar   +4 more sources

CD276 regulates the immune escape of esophageal squamous cell carcinoma through CXCL1–CXCR2 induced NETs

Journal for ImmunoTherapy of Cancer
Background CD276 (B7-H3), a pivotal immune checkpoint, facilitates tumorigenicity, invasiveness, and metastasis by escaping immune surveillance in a variety of tumors; however, the underlying mechanisms facilitating immune escape in esophageal squamous ...
Yu Liang, Shuang Chen, Zhi Chen, Fang Peng, Qianwen Liu, Gan Xiong, Caihua Zhang, Maosheng Cheng, Rongsong Ling, Demeng Chen, Qimin Zhou   +10 more
doaj   +2 more sources

Prognostic significance of CD276 in non-small cell lung cancer [PDF]

Open Medicine, 2019
The expression and significance of CD276 in non-small cell lung cancer (NSCLC) was explored.
Zhang Changgong, Hao Xuezhi
doaj   +3 more sources

CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models

Journal of Experimental & Clinical Cancer Research, 2023
Background Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood, whose prognosis is still poor especially for metastatic, high-grade, and relapsed RMS. New treatments are urgently needed, especially systemic therapies.
Andrea Timpanaro, Caroline Piccand, Dzhangar Dzhumashev, Stenija Anton-Joseph, Andrea Robbi, Janine Moser, Jochen Rössler, Michele Bernasconi   +7 more
doaj   +4 more sources