Results 191 to 200 of about 8,868 (210)

Prevalence and Clinical Association of CD276 (B7-H3) Expression in Pleural Mesothelioma: Results From the European Thoracic Platform Mesoscape Project

JCO Precision Oncology
PURPOSE CD276 (B7-H3) is an immunoregulatory protein that plays an important role in the inhibition of T-cell function. CD276 is overexpressed on a variety of human solid cancer cells with limited expression in normal tissues, making it an appealing ...
Martina Haberecker, J. H. Rüschoff, Charitini Andriakopoulou, Steven G. Gray, K. Nackaerts, Marc de Perrot, Luka Brčić, E. Nadal, S. Tsimpoukis, L. Ampollini, J. Aerts, Michaela B. Kirschner, K. Monkhorst, B. Weynand, F. Bavaghar-Zaeimi, Miroslav Samaržija, R. Llatjós, S. P. Finn, E. Silini, Jan von der Thüsen, P. Vagenknecht, Z. Tsourti, Keith M Kerr, R. Kammler, Solange Peters, P. Baas, Isabelle Opitz, R. Stahel, A. Curioni-Fontecedro   +28 more
semanticscholar   +1 more source

From tumor immunity to precision medicine: the next step in B7-H3/CD276 research

Medical Review
B7-H3 (CD276) is one of the immune checkpoint molecules at the forefront of cancer biology, plays a diverse role in immune regulation and cancer progression, while its immunosuppressive functions enable tumors to escape immune detection, its contribution
Haolie Fang, Yuqian Liu, Gege Wang, Heng-Jia Liu   +3 more
semanticscholar   +1 more source

Abstract P1-06-25: B7-H3 (CD276): A Metabolic Switch for the Survival of Breast Cancer Brain Metastasis

Clinical Cancer Research
Introduction: Up to 30% of cancer patients will have brain metastasis (BrM) at the time of their death, particularly those with lung cancer, breast cancer (BC), and melanoma.
Asad Ur Rehman, Jaewon Lee, Ranjana K. Kanchan, Parvez Khan, Mahek Fatima, Mohd Ali Abbas Zaidi, Md Arafat Khan, Laiba Anwar, Jesse L. Cox, Sidharth Mahapatra, Surinder K. Batra, Brad St. Croix, Juan A. Santamaria-Barria, M. Nasser   +13 more
semanticscholar   +1 more source

Effects of nuclear CD276 on CD36-mediated lipid metabolism reprogramming on TKI resistance in hepatoma..

Journal of Clinical Oncology
e16174 Background: The clinical benefit of tyrosine kinase inhibitors (TKIs)-based systemic therapy for advanced hepatocellular carcinoma (HCC) is limited due to drug resistance.
Xiaojuan Huang, W. Qiu
semanticscholar   +1 more source

Characterization and impact of B7-H3 ( CD276 ) expression across disease states and racial groups in prostate cancer.

Journal of Clinical Oncology
5073 Background: B7-H3 ( CD276 ) is an immunomodulatory protein overexpressed in prostate cancer (PC), representing a promising therapeutic target.
Justin H. Hwang, N. Gandhi, Allison Makovec, Norm D Smith, A. Elliott, Vivek Narayan, E. Shenderov, Elisabeth I. Heath, Nicholas A. Zorko, E. Antonarakis, Rana R McKay   +10 more
semanticscholar   +1 more source

Optimal dosing of vobramitamab duocarmazine, a CD276 (B7-H3) antibody-drug conjugate, leads to durable eradication of Acute Myeloid Leukemia in preclinical xenograft models

Blood
CD276 (B7-H3) is an immune checkpoint inhibitor aberrantly expressed in a majority of solid tumors and hematologic malignancies, with limited data on the therapeutic potential of targeting CD276 in acute myeloid leukemia (AML).
Danielle C Kirkey, Melia Blankenfeld, Deryk Loo, Isabel Lira, Grace Hawkins, Nika Panahi, Bruce Liu, R. Ries, Jack H. Peplinski, Ezio Bonvini, Stephen Eck, S. Meshinchi   +11 more
semanticscholar   +1 more source

Abstract 4875: B7-H3 (CD276) regulates the migration and infiltration of tumor-associated macrophages

Cancer Research
B7-H3 (CD276), a member of the B7 family of immune checkpoint proteins, is expressed on tumor cells as well as various immune cells within the tumor microenvironment (TME), including macrophages.
A-Ram Kang, Da Hyun Yun, E. Lee, Jong Dae Ji, Serkin Park   +4 more
semanticscholar   +1 more source

Involvement of the disulfidptosis-related immune checkpoint gene, CD276, in glioblastoma malignant phenotype and poor prognosis

Neurological Research
Background Immunotherapy has promise for glioblastoma multiforme (GBM) treatment and disulfidptosis, a form of cell death involving disintegration of the actin cytoskeleton, is a potential target.
Jianwei Zhuo, Jing Zhang, Yinong Xu, Meng Ji, Haitao Shen, Gang Cui   +5 more
semanticscholar   +1 more source

FLT3/ITD-driven noncanonical STAT1 S727 phosphorylation upregulates CD276, mediating CD8positive- T cell exhaustion and immune evasion in AML

Blood
FMS-like tyrosine kinase 3 internal tandem duplications (FLT3/ITD) mutation promotes leukemogenesis and confers poor prognosis in acute myeloid leukemia (AML).
Yun Wang, Shuzhao Chen, Shutong Liu, Zhijian Liang, Chunhua Li, Yang Liang   +5 more
semanticscholar   +1 more source

Abstract 2607: Dual payload immunochemotherapy to treat CD276 positive cancers

Cancer Research
Abstract The Cancer Genome Atlas (TCGA) dataset showed higher level of CD276 (B7-H3) transcript in multiple cancers, including triple-negative breast cancers (TNBCs), non-small cell lung cancers (NSCLCs) and other cancers, than normal tissues.
Zhuoxin Zora Zhou, Jiashuai Zhang, Lufang Zhou, Xiaoguang Margaret Liu   +3 more
openaire   +1 more source