Results 31 to 40 of about 8,868 (210)

Rapidly-manufactured CD276 CAR-T cells exhibit enhanced persistence and efficacy in pancreatic cancer

Journal of Translational Medicine
Background Pancreatic cancer is one of the most lethal malignancies and the lack of treatment options makes it more deadly. Chimeric Antigen Receptor T-cell (CAR-T) immunotherapy has revolutionized cancer treatment and made great breakthroughs in ...
Tian Deng, Yingzhi Deng, Shih-Ting Tsao, Qinghui Xiong, Yue Yao, Cuicui Liu, Ming yuan Gu, Fei Huang, Haiying Wang   +8 more
doaj   +2 more sources

B7-H3/CD276: An Emerging Cancer Immunotherapy [PDF]

Frontiers in Immunology, 2021
Immunotherapy aiming at suppressing tumor development by relying on modifying or strengthening the immune system prevails among cancer treatments and points out a new direction for cancer therapy. B7 homolog 3 protein (B7-H3, also known as CD276), a newly identified immunoregulatory protein member of the B7 family, is an attractive and promising target
Wu-Tong Zhou, Wei-Lin Jin, Wei-Lin Jin
openaire   +3 more sources

Establishment of a pathomic-based machine learning model to predict CD276 (B7-H3) expression in colon cancer

Frontiers in Oncology
CD276 is a promising prognostic indicator and an attractive therapeutic target in various malignancies. However, current methods for CD276 detection are time-consuming and expensive, limiting extensive studies and applications of CD276.
Jia Li, Dongxu Wang, Chenxin Zhang
doaj   +2 more sources

The B7-H3 (CD276) pathway: emerging biology and clinical therapeutics.

Trends in Pharmacological Sciences
Devin T. Corrigan, Ankit Tanwar, Meirong Du, Allison M Martin, Xingxing Zang   +4 more
semanticscholar   +2 more sources

Integrated analysis identifies CD276 in fibroblasts as a malignancy predictor and regulator of neutrophil infiltration in hepatoblastoma. [PDF]

Hepatol Commun
Background: Hepatoblastoma is the most prevalent liver cancer in children. Immunotherapy targeting immune checkpoint molecules has become pivotal in various cancer treatments.
Ding M, Zhu G, Chen T, Zhu J, Mao S, Tang X, Wu H, Zhen N, Sun F, Pan Q, Ma J.   +10 more
europepmc   +2 more sources

Progress on the pathological roles of immune checkpoint CD276 protein in tumorigenesis and development [PDF]

Jichu yixue yu linchuang, 2023
The immune checkpoint CD276 protein, belonging to the B7 family molecules, could interact with important signaling pathways, such as phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT)signaling pathway, resulting to the regulation of tumor energy ...
CHEN Zhongjie, HUANG Jiaru, HU Qing, ZHAO Zhenqin, CHEN Qiaoqiao, SUN Junyuan, JIA Jing
doaj   +1 more source

CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1

Scientific Reports, 2021
More than 70% of colorectal, prostate, ovarian, pancreatic and breast cancer specimens show expression of CD276 (B7–H3), a potential immune checkpoint family member.
Sibel Durlanik, Katrin Fundel-Clemens, Coralie Viollet, Heinrich J. Huber, Martin Lenter, Kerstin Kitt, Stefan Pflanz   +6 more
doaj   +1 more source

Targeting CD276 by CAR-T cells induces regression of esophagus squamous cell carcinoma in xenograft mouse models

Translational Oncology, 2021
Esophageal cancer, including esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), has a poor prognosis and limited therapeutic options. Chimeric antigen receptor (CAR)-T cells represent a potential ESCC treatment. In this study,
Yujing Xuan, Yuqiao Sheng, Daiqun Zhang, Kai Zhang, Zhen Zhang, Yu Ping, Shumin Wang, Xiaojuan Shi, Jingyao Lian, Kangdong Liu, Yi Zhang, Feng Li   +11 more
doaj   +1 more source

Multi-omics analyses of CD276 in pan-cancer reveals its clinical prognostic value in glioblastoma and other major cancer types

BMC Cancer, 2023
Background CD276 (also known as B7-H3) is one of the most important immune checkpoints of the CD28 and B7 superfamily, and its abnormal expression is closely associated with various types of cancer.
Lirui Dai, Xuyang Guo, Zhe Xing, Yiran Tao, Wulong Liang, Zimin Shi, Weihua Hu, Shaolong Zhou, Xinjun Wang   +8 more
doaj   +1 more source

Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. [PDF]

, 2020
Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar.
Baglieri, Jacopo, Benner, Chris, Brenner, David, Chen, Yibu, Diggle, Karin, Dorko, Ken, Hosseini, Mojgan, Kisseleva, Tatiana, Lam, Kevin, Liu, Xiao, Meshgin, Nairika, Musallam, Sami G, Pan, Stephanie Q, Presnell, Sharon, Rosenthal, Sara Brin, Tsukamoto, Hidekazu, Wu, Raymond   +16 more
core   +1 more source