Results 41 to 50 of about 8,868 (210)

295 CD276-mediated fratricide limits CD276-CAR-T cell fitness

Regular and Young Investigator Award Abstracts
Wei Xiong, Peirong Hu, Michael Wagner, Sayyed Hamid Zarkesh Esfahani, Ngoc Q Tran, Xu Wang, Kun Luo, T. Tran, Alun J Carter, R. Orentas   +9 more
semanticscholar   +2 more sources

Targeting CD276: a promising strategy for CAR-NK cell immunotherapy in human oral tongue squamous cell carcinoma. [PDF]

BMC Cancer
Human oral tongue squamous cell carcinoma (OTSCC) is a prevalent form of head and neck squamous cell carcinoma (HNSCC), often presenting at an advanced stage with a grim prognosis. Traditional therapeutic approaches such as surgery, adjuvant radiotherapy,
Liu S, Guan T, Yang F, Zhang H, Yao Y, Huang J, Zhao P, Huang W, Wu T, Lin H, Fu T, Chen S, Dai P, Ding Z, Chen D, Li W, Zeng H, Zhang X.   +17 more
europepmc   +2 more sources

Suppressive function of bone marrow-derived mesenchymal stem cell-derived exosomal microRNA-187 in prostate cancer

Cancer Biology & Therapy, 2022
Application of bone marrow-derived mesenchymal stem cell-derived exosomes (BMSC-exos) in cancer treatment has been widely studied. Here, we elaborated the function of BMSC-exos containing microRNA-187 (miR-187) in prostate cancer.
Chuangui Li, Zhen Sun, Yajun Song, Yong Zhang   +3 more
doaj   +1 more source

Molecular Pathways: Targeting B7-H3 (CD276) for Human Cancer Immunotherapy [PDF]

Clinical Cancer Research, 2016
Abstract B7-H3 (CD276) is an important immune checkpoint member of the B7 and CD28 families. Induced on antigen-presenting cells, B7-H3 plays an important role in the inhibition of T-cell function. Importantly, B7-H3 is highly overexpressed on a wide range of human solid cancers and often correlates with both negative prognosis and poor ...
Elodie, Picarda, Kim C, Ohaegbulam, Xingxing, Zang   +2 more
openaire   +2 more sources

Endothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells [PDF]

, 2014
Background:Mature circulating endothelial cells (CEC) are surrogate markers of endothelial damage. CEC measured in patients with advanced cancer are thought not only to derive from damaged normal vasculature (n-CEC ...
A Ouhtit, AI Chapoval, AW Griffioen, B Croix St, C Verhoef, D J Grunhagen, D Lemke, DM McDonald, F Bertolini, F Dignat-George, GN Naumov, HR Lijnen, I Yamato, J Hagendoorn, J Kraan, J Kraan, J Kraan, J W Gratama, JA Nagy, JL Rowand, K Broll, K Hida, KH Plate, L Zimmerlin, M Crisan, MH Strijbos, N Maishi, P Carmeliet, P Steinberger, P van den Broek, PK Goon, PL Crispen, R Minhajat, R Wurth, S Seaman, S Sleijfer, SE Duff, TJ Roth, W Taal, X Qin, X Zang, Y Sun, YQ Xiong   +42 more
core   +4 more sources

CD276 (B7H3) improve cancer stem cells formation in cervical carcinoma cell lines [PDF]

Translational Cancer Research, 2021
Cancer stem cells (CSCs) have been considered as a potential therapeutic target for cervical carcinoma. CD 276 is a well-known immune check point molecular, but its relationship with cervical CSCs was still unclear.HeLa cell lines were obtained as cervical carcinoma in vitro model.
Shi, Jianfeng, Zhao, Haishan, Lian, Huan, Ke, Linnan, Zhao, Lei, Wang, Chunren, Han, Qianqian   +6 more
openaire   +2 more sources

Cellular interactions in the tumor microenvironment: the role of secretome [PDF]

, 2019
Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix ...
Castelo-Branco, Pedro, da Cunha, Bianca Rodrigues, Domingos, Célia, Henrique, Tiago, Polachini, Giovana Mussi, Stefanini, Ana Carolina Buzzo, Tajara, Eloiza Helena   +6 more
core   +1 more source

CD276 as a Candidate Target for Immunotherapy in Medullary Thyroid Cancer

International Journal of Molecular Sciences, 2023
Medullary thyroid cancer (MTC) is a rare malignancy, and the treatment of metastatic MTC is challenging. In previous work, immune profiling (RNA-Seq) of MTC identified CD276 as a potential target for immunotherapy. CD276 expression was 3-fold higher in MTC cells than in normal tissues.
Kinga Hińcza-Nowak, Artur Kowalik, Agnieszka Walczyk, Iwona Pałyga, Danuta Gąsior-Perczak, Agnieszka Płusa, Janusz Kopczyński, Magdalena Chrapek, Stanisław Góźdź, Aldona Kowalska   +9 more
openaire   +2 more sources

Identification of Cell Surface Proteins as Potential Immunotherapy Targets in 12 Pediatric Cancers [PDF]

, 2012
Technological advances now allow us to rapidly produce CARs and other antibody-derived therapeutics targeting cell surface receptors. To maximize the potential of these new technologies, relevant extracellular targets must be identified.
Crystal L. Mackall, James J. Yang, Javed Khan, Jun S. Wei, Rimas J. Orentas, Xinyu Wen   +5 more
core   +2 more sources

Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production [PDF]

, 2016
Background: Clinical translation of mesenchymal stromal cells (MSCs) necessitates basic characterization of the cell product since variability in biological source and processing of MSCs may impact therapeutic outcomes.
A. Noelle Larson, Allan B. Dietz, Amel Dudakovic, Andre J. van Wijnen, Catalina Galeano Garces, Christopher R. Paradise, Emily T. Camilleri, Hee-Jeong Im Sampen, Hideki Takai, Jay Smith, Marcel Karperien, Michael P. Gustafson, Scott M. Riester, Simon Cool, Wenchun Qu   +14 more
core   +3 more sources