Siah2 control of T-regulatory cells limits anti-tumor immunity. [PDF]
, 2020 Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice.
Aifantis, Ioannis +15 more
core +2 more sources
Cells, 2020 CD276 can discriminate between tumor derived and normal CECs (circulating endothelial cells). We evaluated whether CD276+CEC is a clinically relevant biomarker to predict response to palliative systemic therapy in patients with metastatic colorectal ...
Elske C. Gootjes +7 more
doaj +1 more source
Whole genome semiconductor based sequencing of farmed European sea bass (Dicentrarchus labrax) Mediterranean genetic stocks using a DNA pooling approach [PDF]
, 2016 European sea bass (Dicentrarchus labrax) is an important marine species for commercial and sport fisheries and aquaculture production. Recently, the European sea bass genome has been sequenced and assembled.
Bertolini, F +5 more
core +1 more source
mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion
Nature Communications, 2023 Identifying the mechanisms underlying the regulation of immune checkpoint molecules and the therapeutic impact of targeting them in cancer is critical.
Heng-Jia Liu +7 more
semanticscholar +1 more source
Translational Oncology, 2021 The pancaner molecule CD276 (B7-H3) is an attractive target for antibody based therapy. We identified from a large (1011) phage-displayed single-chain variable fragment (scFv) library, a fully human antibody, B11, which bound with high avidity (KD=0.4 nM)
Xianglei Liu +5 more
doaj +1 more source
International Journal of General Medicine, 2023 Jinye Ding,1 Yaoqi Sun,1 Zubaidan Sulaiman,1 Caixia Li,1,2 Zhongping Cheng,1,2 Shupeng Liu1,2 1Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of ...
Ding J +5 more
doaj
Human Stromal (Mesenchymal) Stem Cells from Bone Marrow, Adipose Tissue and Skin Exhibit Differences in Molecular Phenotype and Differentiation Potential [PDF]
, 2012 Human stromal (mesenchymal) stem cells (hMSCs) are multipotent stem cells with ability to differentiate into mesoderm-type cells e.g. osteoblasts and adipocytes and thus they are being introduced into clinical trials for tissue regeneration ...
Adjaye, James +9 more
core +1 more source
B7H3 ameliorates LPS-induced acute lung injury via attenuation of neutrophil migration and infiltration [PDF]
, 2016 Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by an excessive inflammatory response within the lungs and severely impaired gas exchange resulting from alveolar-capillary barrier disruption and pulmonary edema ...
Foley, Niamh M. +8 more
core +1 more source
Silencing of CD276 suppresses lung cancer progression by regulating integrin signaling
Journal of Thoracic Disease, 2020 Non-small cell lung cancer (NSCLC) is one of the cancers with the highest morbidity and mortality among the world. Studies have shown that the invasion and metastasis of tumor are biological characteristics of lung cancer, and also the main cause of treatment failure and patient death.
Li, Fang, Chen, Hengchi, Wang, Dali
openaire +2 more sources
Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins. [PDF]
, 2016 This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.Asthma is the most common chronic inflammatory disorder in children. The aetiology of asthma pathology is complex and
Ambler, A +10 more
core +1 more source