Results 71 to 80 of about 8,868 (210)

Glutamine transporter SLC1A5 inhibits autophagy-mediated CD276 degradation to promote esophageal cancer progression

Cancer Biology & Therapy
Background CD276/B7-H3 is an immune checkpoint molecule often overexpressed in cancers, representing a potential therapeutic target. The underlying mechanisms for CD276 upregulation remain unclear. This study investigates how glutamine metabolism affects
Chunyan Wang, Hongyan Zhang, Chaonan Guan, Yuying Li, Shengli Yang, Lan Huang   +5 more
doaj   +1 more source

Resolving candidate genes of mouse skeletal muscle QTL via RNA-Seq and expression network analyses [PDF]

, 2012
Peer reviewedPublisher ...
Blizard, David A, Carroll, Andrew M, Derry, Jonathan M J, Lionikas, Arimantas, Meharg, Caroline, Ratkevicius, Aivaras, Vandenbergh, David J   +6 more
core   +2 more sources

Tumor B7-H3 (CD276) Expression and Survival in Pancreatic Cancer

Journal of Clinical Medicine, 2018
B7-H3 (CD276), a member of the family of immune modulators, orchestrates antitumor immunity. To date, only small-sized studies have examined the association of B7-H3 expression with survival in pancreatic cancer, yielding inconclusive results. We evaluated tumor B7-H3 expression in 150 consecutive patients with pancreatic ductal adenocarcinoma using ...
Kentaro Inamura, Yutaka Takazawa, Yosuke Inoue, Yusuke Yokouchi, Maki Kobayashi, Akio Saiura, Tomoko Shibutani, Yuichi Ishikawa   +7 more
openaire   +2 more sources

Erratum: CD276 (B7H3) improve cancer stem cells formation in cervical carcinoma cell lines. [PDF]

Transl Cancer Res
[This corrects the article DOI: 10.21037/tcr-19-2910.].
Editorial Office.
europepmc   +2 more sources

Prognostic value and kinetics of circulating endothelial cells in patients with recurrent glioblastoma randomised to bevacizumab plus lomustine, bevacizumab single agent or lomustine single agent. A report from the Dutch Neuro-Oncology Group BELOB trial [PDF]

, 2015
Background:Angiogenesis is crucial for glioblastoma growth, and anti-vascular endothelial growth factor agents are widely used in recurrent glioblastoma patients.
A M Walenkamp, A Otten, A Salmaggi, AD Blann, B van der Holt, DN Louis, F Y F de Vos, FC Bidard, G Reynes, H M Oosterkamp, HS Friedman, J Kraan, J Kraan, J Kraan, J Kraan, J W Gratama, JM Provenzale, KH Plate, L Beerepoot, L Cuppini, LH Simkens, M E van Linde, M Hanse, M J van den Bent, MH Strijbos, MJ van den Bent, MR Gilbert, N Beije, OL Chinot, P Mancuso, PV Dickson, PY Wen, R M Vernhout, RK Jain, RM Hayward, S Sleijfer, W Taal, W Taal   +37 more
core   +5 more sources

Abstract 2004: Epigenetic targeting of CD276 expression in medullolbastoma

Cancer Research, 2017
Abstract Medulloblastoma (MB) is the most common malignant brain tumor in children and accounts for 20% of pediatric CNS tumors. Following surgery and treatment with chemotherapy and radiation, MBs recur in a significant proportion of patients. Moreover, survivors experience comorbidities related to the tumor and/or its treatment.
Maheedhara R. Guda, Jose R. Castellanos, Collin M. Labak, Ramadevi Sanam, David J. Daniels, Sarah E. Martin, Julian J. Lin, Andrew J. Tsung, Kiran K. Velpula, Swapna Asuthkar   +9 more
openaire   +1 more source

Sex and age differences in the expression of liver microRNAs during the life span of F344 rats [PDF]

, 2017
214 miRNAs differentially expressed by age and/or sex. Each miRNA is shown as differentially expressed by age, sex, or both age and sex, along with the k-means cluster number from Fig. 2 and chromosome mapping position.
Carrie L. Moland, James C. Fuscoe, Joshua C. Kwekel, Tao Han, Varsha G. Desai, Vikrant Vijay   +5 more
core   +6 more sources

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, EarlyView.
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
wiley   +1 more source

Assessment of plasma B7-H3 levels in pediatric patients with different degrees of surgical stress [PDF]

, 2016
Background: Surgical stress initiates a series of host hormone, metabolism and immune responses, which predominantly affect the homeostatic mechanism of patients with major surgery.
Feng, Xing, Huang, Jie, Li, Yan, Li, Yi Ping, Pan, Jian, Wang, Jian, Wang, Jiang Huai, Yuan, Qing, Zhang, Xue Guang   +8 more
core   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source