Results 81 to 90 of about 8,868 (210)

Pan-Cancer Interrogation of B7-H3 (CD276) as an Actionable Therapeutic Target Across Human Malignancies

Cancer Research Communications
B7-H3 (CD276) is a transmembrane glycoprotein of the B7 immune checkpoint superfamily that has emerged as a promising therapeutic target. To better understand the applicability of B7-H3–directed therapies, we analyzed 156,791 samples comprising 50 cancer
Carly D Miller, John R Lozada, Nicholas A. Zorko, A. Elliott, Allison Makovec, M. Radovich, Elisabeth I. Heath, N. Agarwal, R. Mckay, R. Garje, Bruno R Bastos, Dave S.B. Hoon, J. Orme, Oliver Sartor, A. Vanderwalde, C. Nabhan, George W Sledge, E. Shenderov, S. Dehm, E. Lou, Jeffrey S. Miller, Justin H. Hwang, E. Antonarakis   +22 more
semanticscholar   +1 more source

Acid Sphingomyelinase Regulates the Localization and Trafficking of Palmitoylated Proteins [PDF]

, 2019
In human, loss of Acid Sphingomeylinase (ASM/SMPD1) causes Niemann-Pick Disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. ...
Kim, Yongsoon, Lee, Chia-Fang, Li, Wenjing, Sun, Hong, Xiong, Xiahui, Yu, Jiekai, Zhang, Hul, Zhu, Linyu   +7 more
core   +2 more sources

Nano Delivery Strategy Opens Effective Avenues for the Treatment of Colorectal Cancer

Medicine Bulletin, EarlyView.
ABSTRACT Colorectal cancer (CRC) presents significant therapeutic challenges because of chemoresistance, systemic toxicity, and the complexity of the tumor microenvironment (TME). Nanodrug delivery systems (NDDS) have emerged as versatile platforms capable of overcoming these limitations by enhancing tumor accumulation, improving pharmacokinetics, and ...
Qiurong Wei, Yunli Xu, Tianjiao Zhang, Shuyu Xu, Haonan Wang, Yuan Wang, Xinxin Xie, Xiaolong Liang   +7 more
wiley   +1 more source

B7-H3 Inhibitors in Oncology Clinical Trials: A Review [PDF]

Journal of Immunotherapy and Precision Oncology
B7-H3 is a transmembrane receptor highly prevalent on malignant cells and plays an important role in adaptive immunity that is not fully elucidated.
Kavanya Feustel, Jared Martin, Gerald S. Falchook   +2 more
doaj   +1 more source

Lateral interactions between CD276 and CD147 are essential for stemness in breast cancer: a novel insight from proximal proteome analysis

Scientific Reports, 2023
Oncogenic cell-surface membrane proteins contribute to the phenotypic and functional characteristics of cancer stem cells (CSCs). We employed a proximity-labeling proteomic approach to quantitatively analyze the cell-surface membrane proteins in close ...
Yu Ri Seo, Junghyeon Lee, Han Suk Ryu, EunHee G. Kim, So Hyun Kim, Jieun Jeong, Hyeryeon Jung, YeoJin Jung, Han Byeol Kim, Yeon Hui Jo, Yeong Dong Kim, Min-Sun Jin, Yong Yook Lee, Kristine M. Kim, Eugene C. Yi   +14 more
doaj   +1 more source

Optimal combination of immune checkpoint and senescence molecule predicts adverse outcomes in patients with acute myeloid leukemia

Annals of Medicine, 2023
Background High expression of immune checkpoints (ICs) and senescence molecules (SMs) contributes to T cell dysfunction, tumor escape, and progression, but systematic evaluation of them in co-expression patterns and prognosis in acute myeloid leukemia ...
Peipei Wang, Yuling Zhang, Qinghua Cai, Qingqin Long, Shiyi Pan, Wei Zhou, Tingfen Deng, Wenjian Mo, Shunqing Wang, Yuping Zhang, Caixia Wang, Cunte Chen   +11 more
doaj   +1 more source

Semi Mature Blood Dendritic Cells Exist in Patients with Ductal Pancreatic Adenocarcinoma Owing to Inflammatory Factors Released from the Tumor

, 2010
Background: Much evidence exists regarding the fact that blood DCs, both myeloid DCs (MDCs) and plasmacytoid DCs (PDCs), are negatively affected in different types of cancer, with both reduced numbers and impaired functionality.
Borch, Kurt, Larsson, Marie, Messmer, Davorka, Sandström, Per, Spångeus, Anna, Tjomsland, Vegard   +5 more
core   +1 more source

Immunomodulatory effects of heat killed 'Mycobacterium obuense' on human blood dendritic cells [PDF]

, 2017
Heat-killed (HK) Mycobacterium obuense is a novel immunomodulator, currently undergoing clinical evaluation as an immunotherapeutic agent in the treatment of cancer. Here, we examined the effect of in vitro exposure to HK M. obuense on the expression of
Achkar, Marcel, Akle, Charles, Bahr, Georges, Bazzi, Samer, Modjtahedi, Helmout, Mudan, Satvinder   +5 more
core   +1 more source

Genetically predicted KIR2DS4 mediate the association between gut microbe K10 and osteoporosis fractures: A mediation Mendelian randomization study

PM&R, EarlyView.
Abstract Background Osteoporosis fractures pose a significant public health concern, leading to substantial morbidity and mortality rates. The emerging evidence on the potential link between gut microbiota, proteins, and osteoporosis fractures suggests a complex relationship that warrants further investigation.
Qiong Wang, Qing Kuang, Cheng Chen, Binru Wang, Wei Xiang, Xinming Li, Jianjiao Mou   +6 more
wiley   +1 more source

Endocrine Resistance Score Based on Three Key Genes Predicts Prognosis and Reveals Potential Therapeutic Targets for ER+HER2− Breast Cancer

Cell Proliferation, EarlyView.
We generated endocrine‐resistant BC cell lines and identified CLEC3A, PCDH10, and ST3GAL1 as key endocrine‐resistant genes. More importantly, we validated their role in mediating resistance through PI3K‐AKT signalling and developed a predictive ERS with strong clinical relevance.
Liqin Ping, Lewei Zhu, Nian Chen, Xikun Liu, Jirui Zhong, Xiaoqing Sun, Hailin Tang, Kaiming Zhang   +7 more
wiley   +1 more source