Results 161 to 170 of about 142,249 (285)

Overcoming the undruggable barrier: Structure-guided discovery of a potent small molecule CD28 antagonist with translational potential. [PDF]

Biomed Pharmacother
Upadhyay S, Nada H, Cho S, Gabr MT.
europepmc   +1 more source

CD28 enhances mitochondrial function [PDF]

Nature Immunology, 2017
openaire   +2 more sources

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

CD28 receptor [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

PD-1 targets CD28 [PDF]

Nature Immunology, 2017
openaire   +2 more sources

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, EarlyView.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

Multidimensional mapping of stimulation-responsive regulatory elements and candidate causal variants in T cell activation. [PDF]

Sci Adv
Wang Z, Dong W, Feng X, Xu X, An Y, Xiao H, Luo M, Liang Q, Bai R, Zhao K, Wu L, Zhao L, Zhou Y, Yi X, Huang D, Sengupta K, Plewczynski D, Sham PC, Liu C, Yu Y, Li W, Gong Q, Song W, Zhou W, Li MJ.   +24 more
europepmc   +1 more source

CD28 Positive [PDF]

, 2020
openaire   +1 more source

Immature dendritic cells induce hyporesponsiveness to alloantigens in vitro and prolong mouse cardiac allograft survival [PDF]

, 1995
Fu, F, Fung, JJ, Lu, L, Qian, S, Starzl, TE, Thomson, AW   +5 more
core  

A Murine Bispecific Antibody Efficiently Redirects T Cells Against Calr Mutated Stem Cells In Vivo

American Journal of Hematology, EarlyView.
ABSTRACT Calreticulin (CALR) mutations are prevalent in 20%–30% of patients with BCR::ABL1‐negative myeloproliferative neoplasms (MPN). Mutant calreticulin (mutCALR), presented by the thrombopoietin receptor (MPL, also known as TPOR or CD110) on the surface of the disease‐initiating MPN progenitors, represents an ideal target for curative ...
Shengen Xiong, Tamara Wais, Cecilia Varga, Christina Schueller, Sarada Achyutuni, Robert Kralovics   +5 more
wiley   +1 more source